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Corpus callosum morphology across the lifespan in baboons (Papio anubis): A cross-sectional study of relative mid-sagittal surface area and thickness
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In: ISSN: 0168-0102 ; EISSN: 1872-8111 ; Neuroscience Research ; https://hal-amu.archives-ouvertes.fr/hal-03196956 ; Neuroscience Research, Elsevier, 2021, ⟨10.1016/j.neures.2021.03.002⟩ (2021)
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Corpus callosum morphology across the lifespan in baboons ( Papio anubis ): a cross-sectional study of relative mid-sagittal surface area and thickness
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In: https://hal.archives-ouvertes.fr/hal-03086043 ; 2020 (2020)
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Abstract:
The axons forming the corpus callosum enable integration and coordination of cognitive processing between the cerebral hemispheres. In the aging human brain, these functions are affected by progressive axon and myelin deteriorations, which results in a substantial atrophy of the midsagittal corpus callosum in old age. In non-human primates, these degenerative processes are less pronounced as previous morphometric studies on capuchin monkey, rhesus monkeys, and chimpanzees do not find old-age callosal atrophy. The objective of the present study was to extend these previous findings by studying the aging trajectory of the corpus callosum of the olive baboon ( Papio anubis ) across the lifespan. For this purpose, total relative (to forebrain volume) midsagittal area, subsectional area, and regional thickness of the corpus callosum was assessed in 91 male and female animals using non-invasive MRI-based morphometry. The studied age range was 2.5 to 26.6 years, and the sample included 11 old-age animals (above the age of 20 years). Fitting lifespan trajectories using general additive modelling (GAM) we found that the relative area of the total corpus callosum and the anterior subsection follow a positive linear trajectory. That is, both measures increased slowly but continuously from childhood into old age, and no stagnation of growth or decline was observed in old age. Thus, comparable with all other non-human primates studied to-date, baboons do not show callosal atrophy in old age. This observation lends supports to the notion that atrophy of the corpus callosum is a unique characteristic of human brain aging.
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Keyword:
[SCCO.NEUR]Cognitive science/Neuroscience; [SCCO]Cognitive science
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URL: https://hal.archives-ouvertes.fr/hal-03086043 https://hal.archives-ouvertes.fr/hal-03086043/file/Westerhausen_Meguerditchian_BioRxiv_2020.12.07.414367v1.full.pdf https://doi.org/10.1101/2020.12.07.414367 https://hal.archives-ouvertes.fr/hal-03086043/document
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Parallel but independent reduction of emotional awareness and corpus callosum connectivity in older age
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Laterality across languages: Results from a global dichotic listening study using a smartphone application
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The Right Planum Temporale Is Involved in Stimulus-Driven, Auditory Attention – Evidence from Transcranial Magnetic Stimulation
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“Right on all Occasions?” – On the Feasibility of Laterality Research Using a Smartphone Dichotic Listening Application
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Structural and Functional Reorganization of the Corpus Callosum between the Age of 6 and 8 Years
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Structural and Functional Reorganization of the Corpus Callosum between the Age of 6 and 8 Years
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Structural and Functional Reorganization of the Corpus Callosum between the Age of 6 and 8 Years
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Functional Relevance of Interindividual Differences in Temporal Lobe Callosal Pathways: A DTI Tractography Study
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Functional Relevance of Interindividual Differences in Temporal Lobe Callosal Pathways: A DTI Tractography Study
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