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Development of a standard of care for patients with valosin-containing protein associated multisystem proteinopathy.
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In: Orphanet journal of rare diseases, vol 17, iss 1 (2022)
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Family history of FXTAS is associated with age-related cognitive-linguistic decline among mothers with the FMR1 premutation.
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In: Journal of neurodevelopmental disorders, vol 14, iss 1 (2022)
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Cortical microstructure in primary progressive aphasia: a multicenter study.
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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Hippocampal ensembles represent sequential relationships among an extended sequence of nonspatial events.
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In: Nature communications, vol 13, iss 1 (2022)
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Neural dynamics of semantic categorization in semantic variant of primary progressive aphasia.
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Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
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| 7 |
Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation.
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In: Human brain mapping, vol 42, iss 14 (2021)
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B Cell-Restricted Depletion of Dnmt3a Activates Notch Signaling and Causes Chronic Lymphocytic Leukemia
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In: Blood, vol 138, iss Supplement 1 (2021)
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Comparing two facets of emotion perception across multiple neurodegenerative diseases.
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In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020)
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Amount and delay insensitivity during intertemporal choice in three neurodegenerative diseases reflects dorsomedial prefrontal atrophy.
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Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
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Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
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Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
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| 14 |
Graded, multidimensional intra- and intergroup variations in primary progressive aphasia and post-stroke aphasia.
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In: Brain : a journal of neurology, vol 143, iss 10 (2020)
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| 15 |
Regional and hemispheric susceptibility of the temporal lobe to FTLD-TDP type C pathology.
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| 16 |
Amount and delay insensitivity during intertemporal choice in three neurodegenerative diseases reflects dorsomedial prefrontal atrophy.
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| 17 |
A neurophysiological model of speech production deficits in fragile X syndrome.
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In: Brain communications, vol 2, iss 1 (2020)
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The Relationship between Expressive Language Sampling and Clinical Measures in Fragile X Syndrome and Typical Development.
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In: Brain sciences, vol 10, iss 2 (2020)
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Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
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In: Molecular psychiatry, vol 25, iss 10 (2020)
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| 20 |
Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
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Bigdeli, Tim B; Genovese, Giulio; Georgakopoulos, Penelope; Meyers, Jacquelyn L; Peterson, Roseann E; Iyegbe, Conrad O; Medeiros, Helena; Valderrama, Jorge; Achtyes, Eric D; Kotov, Roman; Stahl, Eli A; Abbott, Colony; Azevedo, Maria Helena; Belliveau, Richard A; Bevilacqua, Elizabeth; Bromet, Evelyn J; Byerley, William; Carvalho, Celia Barreto; Chapman, Sinéad B; DeLisi, Lynn E; Dumont, Ashley L; O'Dushlaine, Colm; Evgrafov, Oleg V; Fochtmann, Laura J; Gage, Diane; Kennedy, James L; Kinkead, Becky; Macedo, Antonio; Moran, Jennifer L; Morley, Christopher P; Dewan, Mantosh J; Nemesh, James; Perkins, Diana O; Purcell, Shaun M; Rakofsky, Jeffrey J; Scolnick, Edward M; Sklar, Brooke M; Sklar, Pamela; Smoller, Jordan W; Sullivan, Patrick F; Macciardi, Fabio; Marder, Stephen R; Gur, Ruben C; Gur, Raquel E; Braff, David L; Consortium on the Genetics of Schizophrenia (COGS) Investigators; Nicolini, Humberto; Escamilla, Michael A; Vawter, Marquis P; Sobell, Janet L; Malaspina, Dolores; Lehrer, Douglas S; Buckley, Peter F; Rapaport, Mark H; Knowles, James A; Genomic Psychiatry Cohort (GPC) Consortium; Fanous, Ayman H; Pato, Michele T; McCarroll, Steven A; Pato, Carlos N
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In: Molecular psychiatry, vol 25, iss 10 (2020)
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Abstract:
Schizophrenia is a common, chronic and debilitating neuropsychiatric syndrome affecting tens of millions of individuals worldwide. While rare genetic variants play a role in the etiology of schizophrenia, most of the currently explained liability is within common variation, suggesting that variation predating the human diaspora out of Africa harbors a large fraction of the common variant attributable heritability. However, common variant association studies in schizophrenia have concentrated mainly on cohorts of European descent. We describe genome-wide association studies of 6152 cases and 3918 controls of admixed African ancestry, and of 1234 cases and 3090 controls of Latino ancestry, representing the largest such study in these populations to date. Combining results from the samples with African ancestry with summary statistics from the Psychiatric Genomics Consortium (PGC) study of schizophrenia yielded seven newly genome-wide significant loci, and we identified an additional eight loci by incorporating the results from samples with Latino ancestry. Leveraging population differences in patterns of linkage disequilibrium, we achieve improved fine-mapping resolution at 22 previously reported and 4 newly significant loci. Polygenic risk score profiling revealed improved prediction based on trans-ancestry meta-analysis results for admixed African (Nagelkerke's R2 = 0.032; liability R2 = 0.017; P < 10-52), Latino (Nagelkerke's R2 = 0.089; liability R2 = 0.021; P < 10-58), and European individuals (Nagelkerke's R2 = 0.089; liability R2 = 0.037; P < 10-113), further highlighting the advantages of incorporating data from diverse human populations.
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Keyword:
2.1 Biological and endogenous factors; Biological Sciences; Blacks; Brain Disorders; Consortium on the Genetics of Schizophrenia (COGS) Investigators; Female; Genetic Loci; Genetic Predisposition to Disease; Genetics; Genome-Wide Association Study; Genomic Psychiatry Cohort (GPC) Consortium; Hispanic or Latino; Human Genome; Humans; Male; Medical and Health Sciences; Mental Health; Polymorphism; Psychiatry; Psychology and Cognitive Sciences; Schizophrenia; Serious Mental Illness; Single Nucleotide
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URL: https://escholarship.org/uc/item/5gk7n9bq
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