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The perspectives of augmentative and alternative communication experts on the clinical integration of non-invasive brain-computer interfaces
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In: Special Education and Communication Disorders Faculty Publications (2022)
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| 2 |
Development of Gaussian Learning Algorithms for Early Detection of Alzheimer's Disease
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In: FIU Electronic Theses and Dissertations (2020)
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Significance of Phonological Features in Speech Emotion Recognition
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In: Faculty Publications (2020)
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Similarities and Differences of Equine Assisted Speech Therapy and Traditional Speech Therapy –A Retrospective Study
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In: UCARE Research Products (2020)
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| 5 |
An investigation of therapeutic rapport through prosody in brief psychodynamic psychotherapy
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In: Conference Papers (2019)
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| 6 |
Dynamic effects of habituation and novelty detection on newborn event related potentials
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In: Center for Brain, Biology and Behavior: Papers & Publications (2019)
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| 7 |
Taste Manipulation and Swallowing Mechanics in Trauma-Related Sensory-Based Dysphagia
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In: Special Education and Communication Disorders Faculty Publications (2019)
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| 8 |
Motor-Induced Suppression of the N100 Event-Related Potential During Motor Imagery Control of a Speech Synthesizer Brain–Computer Interface
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In: Special Education and Communication Disorders Faculty Publications (2019)
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| 9 |
Developing a real-time translator from neural signals to text: An articulatory phonetics approach
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In: Proceedings of the Society for Computation in Linguistics (2019)
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| 10 |
Developing a Bilingual, Computer-Tailored, HPV Vaccination Promotion Intervention Targeting Latino Parents
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In: Ashish Amresh (2018)
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| 11 |
Assessing Speech-Language Pathologists’ Knowledge and Use of Language Acquisition through Motor Planning
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In: Honors Theses (2018)
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| 12 |
Vocal Function Exercises for Normal Voice: With and Without Semi-Occlusion
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In: Theses and Dissertations--Communication Sciences and Disorders (2017)
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| 13 |
Examining the relationship between home literacy environment and neural correlates of phonological processing in beginning readers with and without a familial risk for dyslexia: an fMRI study
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In: Center for Brain, Biology and Behavior: Papers & Publications (2017)
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| 14 |
A Preliminary Study of a Spanish Graphic Novella Targeting Hearing Loss Prevention
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In: Special Education and Communication Disorders Faculty Publications (2017)
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| 15 |
Induction of DUSP9 in Xenografts from Human Breast Cancer Cell Lines increases Mammary Cancer Stem Cells
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In: Journal of Health Disparities Research and Practice (2016)
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Abstract:
Breast cancer remains a complex disease that kills 40,000 women every year. Initiation and progression of breast cancer is influenced by heterogeneous groups of cells, including mammary cancer stem cells (MCSCs). Progression of this dreadful disease is driven by many signaling pathways among which MAPK pathway is highly prominent. Since targeting prominent kinases in MAPK pathway has been unsuccessful to control breast cancer, it is important to examine the phosphatases that regulate the activity of these kinases. Using xenograft model from breast cancer cell lines, our lab has found that during the initial stages of xenograft development (week 1-4, 100-200mg weight), ERK1/2 remains inactive. However, during the later stages of tumor development (week 5-15, 300-700mg weight), we found phospho-ERK1/2, which is the active form of ERK1/2 remains highly up regulated. Our lab has also found that presence of inactive ERK1/2 during the initial stages of tumor development was independent of pMEK1/2, which is the upstream kinase that activates ERK1/2. We have also found that a specific dual specific phosphatase (DUSP9) was induced in the xenografts from breast cancer cell lines during initial stages of their development. I will be examining the significance of DUSP9 induction in the early stages of xenograft development. There are reports that DUSP9-mediated pERK1/2 inactivation has been found to increase mouse embryonic stem cell content. I have been examining the expression levels of MCSCS (Aldehyde dehydrogenase 1(ALDH1)/ OCT3/4 / CD44/SOX2) in various stages of xenograft development and correlating them with DUSP9 expression and pERK1/2. I am examining the expression levels of MCSCs by Western blot analysis as well as qPCR. I have also been treating breast cancer cell line HMLEHRASV12 with MEK inhibitors, in vitro, for inactivating ERK to analyze the levels of mammary cancer stem cells (ALDH1)/ OCT3/4 / CD44/SOX2. I am also examining the levels of DUSP9 as well as the levels of ERK/pERK1/2 /AKT /pAKT in cells treated with MEK1/2 inhibitors in vitro. I intend to determine whether inhibition of pERK1/2 could influence embryonic stem cell content as analyzed by the expression of markers Oct ¾ and Sox2.
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Keyword:
Analytical; and Multicultural Education; Bilingual; Breast Cancer; Community College Leadership; Diagnostic and Therapeutic Techniques and Equipment; Higher Education; Immune System Diseases; Mammary Cancer Stem Cells; Medical Sciences; Medicine and Health Sciences; Multilingual; Public Health; Translational Medical Research; Virus Diseases; Xenograft
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URL: https://digitalscholarship.unlv.edu/jhdrp/vol9/iss5/3
https://digitalscholarship.unlv.edu/cgi/viewcontent.cgi?article=1533&context=jhdrp
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| 16 |
Developing a Bilingual, Computer-Tailored, HPV Vaccination Promotion Intervention Targeting Latino Parents
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In: Publications (2015)
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| 17 |
Physical Feature Encoding and Word Recognition Abilities Are Altered in Children with Intractable Epilepsy: Preliminary Neuromagnetic Evidence
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In: Center for Brain, Biology and Behavior: Papers & Publications (2015)
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| 18 |
Using Visual Scene Displays as Communication Support Options for People with Chronic, Severe Aphasia: A Summary of AAC Research and Future Research Directions
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In: Special Education and Communication Disorders Faculty Publications (2015)
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| 19 |
Face-Referenced Measurement of Perioral Stiffness and Speech Kinematics in Parkinson’s Disease
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In: Center for Brain, Biology and Behavior: Papers & Publications (2015)
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| 20 |
Healing Our Race-Linked Wounds
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In: Carroy U "Cuf" Ferguson, Ph.D. (2015)
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