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Cortical microstructure in primary progressive aphasia: a multicenter study.
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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Social Behavior Observer Checklist: Patterns of Spontaneous Behaviors Differentiate Patients With Neurodegenerative Disease From Healthy Older Adults.
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Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia. ...
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Data from: Primary progressive aphasias and GRN mutations ...
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes
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Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia.
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New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Regional and hemispheric susceptibility of the temporal lobe to FTLD-TDP type C pathology.
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Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts.
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In: Neurology, vol 95, iss 24 (2020)
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes. ...
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Abstract:
OBJECTIVE: Widespread metabolic changes are seen in neurodegenerative disease and could be used as biomarkers for diagnosis and disease monitoring. They may also reveal disease mechanisms that could be a target for therapy. In this study we looked for blood-based biomarkers in syndromes associated with frontotemporal lobar degeneration. METHODS: Plasma metabolomic profiles were measured from 134 patients with a syndrome associated with frontotemporal lobar degeneration (behavioural variant frontotemporal dementia n = 30, non fluent variant primary progressive aphasia n = 26, progressive supranuclear palsy n = 45, corticobasal syndrome n = 33) and 32 healthy controls. RESULTS: Forty-nine of 842 metabolites were significantly altered in frontotemporal lobar degeneration syndromes (after false-discovery rate correction for multiple comparisons). These were distributed across a wide range of metabolic pathways including amino acids, energy and carbohydrate, cofactor and vitamin, lipid and nucleotide pathways. ... : This work was supported by the Holt Fellowship, the Wellcome Trust (103838), the Cambridge Centre for Parkinson-plus, the British Academy (PF160048) and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre Dementia and Neurodegeneration Theme (146281). ...
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Keyword:
Frontotemporal Dementia; Frontotemporal Lobar Degeneration; Humans; Neurodegenerative Diseases; Supranuclear Palsy, Progressive; Syndrome
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URL: https://www.repository.cam.ac.uk/handle/1810/304148 https://dx.doi.org/10.17863/cam.51233
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes ...
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes ...
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes.
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Behavioural disinhibition in the syndromes associated with frontotemporal lobar degeneration
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes
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