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Cortical microstructure in primary progressive aphasia: a multicenter study.
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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Social Behavior Observer Checklist: Patterns of Spontaneous Behaviors Differentiate Patients With Neurodegenerative Disease From Healthy Older Adults.
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Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia. ...
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Data from: Primary progressive aphasias and GRN mutations ...
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes
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Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia.
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Benussi, Alberto; Alberici, Antonella; Samra, Kiran; Russell, Lucy L; Greaves, Caroline V; Bocchetta, Martina; Ducharme, Simon; Finger, Elizabeth; Fumagalli, Giorgio; Galimberti, Daniela; Jiskoot, Lize C; Le Ber, Isabelle; Masellis, Mario; Nacmias, Benedetta; Rowe, James; Sanchez-Valle, Raquel; Seelaar, Harro; Synofzik, Matthis; GENFI Consortium; Rohrer, Jonathan D; Borroni, Barbara. - : Wiley, 2021. : Department of Clinical Neurosciences, 2021. : Alzheimers Dement, 2021
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Abstract:
The presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and encompass a long accrual of progressive biological (preclinical) and then clinical (prodromal) changes, antedating the onset of dementia. The heterogeneity of clinical presentations and the different neuropathological phenotypes have prevented a prior clear description of either preclinical or prodromal FTD. Recent advances in therapeutic approaches, at least in monogenic disease, demand a proper definition of these predementia stages. It has become clear that a consensus lexicon is needed to comprehensively describe the stages that anticipate dementia. The goal of the present work is to review existing literature on the preclinical and prodromal phases of FTD, providing recommendations to address the unmet questions, therefore laying out a strategy for operationalizing and better characterizing these presymptomatic disease stages.
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Keyword:
definition; frontotemporal dementia; frontotemporal lobar degeneration; mild cognitive and/or behavioral and/or motor impairment; mild cognitive impairment; preclinical; presymptomatic; prodromal
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URL: https://doi.org/10.17863/CAM.79392 https://www.repository.cam.ac.uk/handle/1810/331943
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New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Regional and hemispheric susceptibility of the temporal lobe to FTLD-TDP type C pathology.
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Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts.
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In: Neurology, vol 95, iss 24 (2020)
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes. ...
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes ...
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes ...
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes.
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Behavioural disinhibition in the syndromes associated with frontotemporal lobar degeneration
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Metabolomic changes associated with frontotemporal lobar degeneration syndromes
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