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Studying depression through big data analytics on Twitter
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In: TDX (Tesis Doctorals en Xarxa) (2021)
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Tropomyosin autoantibodies associated with checkpoint inhibitor myositis
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In: Research outputs 2014 to 2021 (2020)
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Factors that influence adherence to treatment plans amongst people living with cardiovascular disease: A review of published qualitative research studies
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In: Research outputs 2014 to 2021 (2020)
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Clinical Controversy in Transplantation: Tacrolimus Versus Cyclosporine in Statin Drug Interactions
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In: Pharmacy Practice Faculty Publications (2020)
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Clinical Controversy in Transplantation: Tacrolimus Versus Cyclosporine in Statin Drug Interactions
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In: Pharmacy Practice Faculty Publications (2020)
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New Directions in Treatments Targeting Stroke Recovery.
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In: Stroke, vol 49, iss 12 (2018)
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Serine Protease Inhibitors in Ticks: An Overview of Their Role in Tick Biology and Tick-Borne Pathogen Transmission
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In: ISSN: 2235-2988 ; Frontiers in Cellular and Infection Microbiology ; https://hal.sorbonne-universite.fr/hal-01536659 ; Frontiers in Cellular and Infection Microbiology, Frontiers, 2017, 7, pp.199. ⟨10.3389/fcimb.2017.00199⟩ (2017)
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Abstract:
International audience ; New tick and tick-borne pathogen control approaches that are both environmentally sustainable and which provide broad protection are urgently needed. Their development, however, will rely on a greater understanding of tick biology, tick-pathogen, and tick-host interactions. The recent advances in new generation technologies to study genomes, transcriptomes, and proteomes has resulted in a plethora of tick biomacromolecular studies. Among these, many enzyme inhibitors have been described, notably serine protease inhibitors (SPIs), whose importance in various tick biological processes is only just beginning to be fully appreciated. Among the multiple active substances secreted during tick feeding, SPIs have been shown to be directly involved in regulation of inflammation, blood clotting, wound healing, vasoconstriction and the modulation of host defense mechanisms. In light of these activities, several SPIs were examined and were experimentally confirmed to facilitate tick pathogen transmission. In addition, to prevent coagulation of the ingested blood meal within the tick alimentary canal, SPIs are also involved in blood digestion and nutrient extraction from the meal. The presence of SPIs in tick hemocytes and their involvement in tick innate immune defenses have also been demonstrated, as well as their implication in hemolymph coagulation and egg development. Considering the involvement of SPIs in multiple crucial aspects of tick-host-pathogen interactions, as well as in various aspects of the tick parasitic lifestyle, these molecules represent highly suitable and attractive targets for the development of effective tick control strategies. Here we review the current knowledge regarding this class of inhibitors in tick biology and tick-borne pathogen transmission, and their potential as targets for future tick control trials.
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Keyword:
[SDV.BC]Life Sciences [q-bio]/Cellular Biology; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases; [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology; immune responses; tick serine protease inhibitors; tick-borne pathogens; ticks; tick–host interactions
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URL: https://hal.sorbonne-universite.fr/hal-01536659 https://hal.sorbonne-universite.fr/hal-01536659/document https://hal.sorbonne-universite.fr/hal-01536659/file/fcimb-07-00199.pdf https://doi.org/10.3389/fcimb.2017.00199
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Avanafil - a further step to tailoring patient needs and expectations
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Atomoxetine improved attention in children and adolescents with attention-deficit/hyperactivity disorder and dyslexia in a 16 week, acute, randomized, double-blind trial
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In: PMC (2013)
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Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease.
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In: Psychiatry Res , 207 (1-2) 118 - 126. (2013) (2013)
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A Review of Potential Harmful Interactions between Anticoagulant/Antiplatelet Agents and Chinese Herbal Medicines
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Guideline for the diagnosis and management of myelofibrosis.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2012)
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Semantic memory and language dysfunction in early Alzheimer's disease: a review.
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In: Int J Geriatr Psychiatry , 27 (12) pp. 1209-1217. (2012) (2012)
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Cardiorenal end points in a trial of aliskiren for type 2 diabetes.
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In: New England Journal of Medicine, vol. 367, no. 23, pp. 2204-2213 (2012)
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Short-term serotonergic but not noradrenergic antidepressant administration reduces attentional vigilance to threat in healthy volunteers.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2009)
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Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2008)
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Systematic review comparing meropenem with imipenem plus cilastatin in the treatment of severe infections.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2005)
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Letter to Carl E. Duncan from Farris Bryant. ( 1952-08-08 )
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