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Communication and motor abilities in CAS (Iuzzini-Seigel et al., 2022) ...
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Communication and motor abilities in CAS (Iuzzini-Seigel et al., 2022) ...
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The trans-ancestral genomic architecture of glycemic traits.
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Chen, J; Spracklen, CN; Marenne, G; Varshney, A; Corbin, LJ; Luan, J; Willems, SM; Wu, Y; Zhang, X; Horikoshi, M; Boutin, TS; Mägi, R; Waage, J; Li-Gao, R; Chan, KHK; Yao, J; Anasanti, MD; Chu, AY; Claringbould, A; Heikkinen, J; Hong, J; Hottenga, J-J; Huo, S; Kaakinen, MA; Louie, T; März, W; Moreno-Macias, H; Ndungu, A; Nelson, SC; Nolte, IM; North, KE; Raulerson, CK; Ray, D; Rohde, R; Rybin, D; Schurmann, C; Sim, X; Southam, L; Stewart, ID; Wang, CA; Wang, Y; Wu, P; Zhang, W; Ahluwalia, TS; Appel, EVR; Bielak, LF; Brody, JA; Burtt, NP; Cabrera, CP; Cade, BE; Chai, JF; Chai, X; Chang, L-C; Chen, C-H; Chen, BH; Chitrala, KN; Chiu, Y-F; de Haan, HG; Delgado, GE; Demirkan, A; Duan, Q; Engmann, J; Fatumo, SA; Gayán, J; Giulianini, F; Gong, JH; Gustafsson, S; Hai, Y; Hartwig, FP; He, J; Heianza, Y; Huang, T; Huerta-Chagoya, A; Hwang, MY; Jensen, RA; Kawaguchi, T; Kentistou, KA; Kim, YJ; Kleber, ME; Kooner, IK; Lai, S; Lange, LA; Langefeld, CD; Lauzon, M; Li, M; Ligthart, S; Liu, J; Loh, M; Long, J; Lyssenko, V; Mangino, M; Marzi, C; Montasser, ME; Nag, A; Nakatochi, M; Noce, D; Noordam, R; Pistis, G; Preuss, M; Raffield, L; Rasmussen-Torvik, LJ; Rich, SS; Robertson, NR; Rueedi, R; Ryan, K; Sanna, S; Saxena, R; Schraut, KE; Sennblad, B; Setoh, K; Smith, AV; Sparsø, T; Strawbridge, RJ; Takeuchi, F; Tan, J; Trompet, S; van den Akker, E; van der Most, PJ; Verweij, N; Vogel, M; Wang, H; Wang, C; Wang, N; Warren, HR; Wen, W; Wilsgaard, T; Wong, A; Wood, AR; Xie, T; Zafarmand, MH; Zhao, J-H; Zhao, W; Amin, N; Arzumanyan, Z; Astrup, A; Bakker, SJL; Baldassarre, D; Beekman, M; Bergman, RN; Bertoni, A; Blüher, M; Bonnycastle, LL; Bornstein, SR; Bowden, DW; Cai, Q; Campbell, A; Campbell, H; Chang, YC; de Geus, EJC; Dehghan, A; Du, S; Eiriksdottir, G; Farmaki, AE; Frånberg, M; Fuchsberger, C; Gao, Y; Gjesing, AP; Goel, A; Han, S; Hartman, CA; Herder, C; Hicks, AA; Hsieh, C-H; Hsueh, WA; Ichihara, S; Igase, M; Ikram, MA; Johnson, WC; Jørgensen, ME; Joshi, PK; Kalyani, RR; Kandeel, FR; 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Abstract:
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10-8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.
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URL: https://doi.org/10.1038/s41588-021-00852-9
https://qmro.qmul.ac.uk/xmlui/handle/123456789/72348
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The trans-ancestral genomic architecture of glycemic traits.
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In: Nature genetics, vol. 53, no. 6, pp. 840-860 (2021)
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What Acoustic Studies Tell Us About Vowels in Developing and Disordered Speech
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In: Am J Speech Lang Pathol (2020)
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Early predictors and correlates of communication function in children with cerebral palsy
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In: J Child Neurol (2018)
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Effect of body position on vocal tract acoustics: Acoustic pharyngometry and vowel formants
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Inter‐relationships of functional status in cerebral palsy: analyzing gross motor function, manual ability, and communication function classification systems in children
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Accuracy of perceptually based and acoustically based inspiratory loci in reading
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Accuracy of perceptually based and acoustically based inspiratory loci in reading
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In: Special Education and Communication Disorders Faculty Publications (2010)
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Breath Group Analysis for Reading and Spontaneous Speech in Healthy Adults
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In: Special Education and Communication Disorders Faculty Publications (2010)
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Anatomic development of the oral and pharyngeal portions of the vocal tract: An imaging study1
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