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161
Ecological assessment of emotional enhancement of memory in progressive nonfluent aphasia and Alzheimer’s disease
Kumfor, FL; Hodges, JR; Piguet, O. - : IOS Press, 2014
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162
New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications
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163
Severity and Progression of White Matter Changes in Frontotemporal Dementia Subtypes Using Diffusion Tensor Imaging
Lam, Bonnie, Medical Sciences, Faculty of Medicine, UNSW. - : University of New South Wales., 2014
Abstract: The three main subtypes of frontotemporal dementia (FTD): behavioural-variant FTD (bvFTD), primary progressive aphasia-nonfluent variant (nfv-PPA) and semantic variant (sv-PPA) are characterised by progressive brain atrophy in the frontotemporal regions. The brain white matter also undergoes marked pathological alterations but is less studied. This thesis aimed to study i) the patterns of white matter changes in the three FTD subtypes, ii) the progression of white matter changes in the same FTD subtypes, and iii) the white matter changes in bvFTD with or without the C9orf72 gene expansions. Chapter 3 revealed distinctive patterns of white matter changes in each FTD subtype. White matter alterations were observed in orbitofrontal and anterior temporal tracts in bvFTD, bilateral (left>right) frontotemporal tracts in nfv-PPA and circumscribed left temporal lobe in sv-PPA. These white matter changes greatly overlapped with grey matter changes in bvFTD and nfv-PPA but not in sv-PPA. The white matter abnormalities varied depending on the diffusion tensor imaging (DTI) measurements used, with mean diffusivity being the most sensitive metric for all FTD subtypes.Chapter 4 showed the 12-month longitudinal assessment of white matter changes in the same participants. White matter alterations appeared in regions shown at baseline but with additional changes extending beyond the original regions affected in all FTD subtypes. White matter abnormalities extended far beyond sites of grey matter atrophy in the same time period. Fractional anisotropy and radial diffusivity were most sensitive in detecting white matter abnormalities in this longitudinal assessment. Chapter 5 compared bvFTD cases with or without C9orf72 expansion carriers. C9orf72 expansion carriers did not exhibit the typical frontotemporal white matter changes as shown in non-carriers. Stereotypical behaviour was less prevalent in C9orf72 expansion carriers than non-carriers and the left cingulum and anterior thalamic radiation were predictive of stereotypical behavioural scores. Semantic knowledge was less affected in C9orf72 expansion carriers and the left uncinate fasciculus was predictive of changes in semantic knowledge. These predictions significantly differentiated C9orf72 expansion carriers from non-carriers.Investigations using DTI presented in this thesis improved the understanding of white matter changes in FTD and contributed to the characterisation of the different FTD subtypes.
Keyword: diffusion tensor imaging; Frontotemporal dementia; tract-based spatial statistics; white matter
URL: https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12667/SOURCE02?view=true
http://handle.unsw.edu.au/1959.4/53956
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164
Heterozygous TREM2 mutations in frontotemporal dementia
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165
A meta-analytic review of theory of mind difficulties in behavioural-variant frontotemporal dementia
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166
Interrater reliability of the new criteria for behavioral variant frontotemporal dementia.
In: Neurology, vol 80, iss 21 (2013)
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167
Nonfluent/agrammatic PPA with in-vivo cortical amyloidosis and Pick's disease pathology.
In: Behavioural neurology, vol 26, iss 1-2 (2013)
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168
Predictors of Cognitive Decline in the Early Stages of Parkinson's Disease: A Brief Cognitive Assessment Longitudinal Study
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169
Flavour identification in frontotemporal lobar degeneration.
In: J Neurol Neurosurg Psychiatry , 84 (1) 88 - 93. (2013) (2013)
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170
Neuroimaging in frontotemporal dementia.
In: Int Rev Psychiatry , 25 (2) 221 - 229. (2013) (2013)
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171
White matter disease correlates with lexical retrieval deficits in primary progressive aphasia.
In: Front Neurol , 4 212 - ?. (2013) (2013)
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172
Apraxia of speech and phonological errors in the diagnosis of nonfluent/agrammatic and logopenic variants of primary progressive aphasia
Croot, Karen; Ballard, Kirri; Leyton, Cristian E. - : American Speech-Language-Hearing Association, 2012
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173
Clinical phenotypes and pathology in neurodegeneration ...
Burrell, James R. - : UNSW Sydney, 2012
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174
Primary progressive aphasia ...
Leyton Moscoso, Cristian. - : UNSW Sydney, 2012
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175
TOMM40, APOE, and APOC1 in Primary Progressive Aphasia and Frontotemporal Dementia
Seripa, D; Bizzarro, Alessandra; Pilotto, A. - : IOS Press, 2012
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176
Clinical phenotypes and pathology in neurodegeneration
Burrell, James R, Clinical School - Prince of Wales Hospital, Faculty of Medicine, UNSW. - : University of New South Wales. Clinical School - Prince of Wales Hospital, 2012
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177
Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects
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178
Primary progressive aphasia
Leyton Moscoso, Cristian, Clinical School - Prince of Wales Hospital, Faculty of Medicine, UNSW. - : University of New South Wales. Clinical School - Prince of Wales Hospital, 2012
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179
The Progranulin (GRN) Cys157LysfsX97 Mutation is Associated with Nonfluent Variant of Primary Progressive Aphasia Clinical Phenotype
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180
Cerebrospinal Fluid Tau, p-Tau 181 and Amyloid-β38/40/42 in Frontotemporal Dementias and Primary Progressive Aphasias
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