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1
Household transmission of Neisseria meningitidis in the African meningitis belt: a longitudinal cohort study
In: ISSN: 2214-109X ; The Lancet global health ; https://hal-riip.archives-ouvertes.fr/pasteur-03238489 ; The Lancet global health, Elsevier, 2016, 4 (12), pp.e989-e995. ⟨10.1016/S2214-109X(16)30244-3⟩ (2016)
Abstract: International audience ; BackgroundInformation on transmission of meningococcal infection in the African meningitis belt is scarce. We aimed to describe transmission patterns of Neisseria meningitidis (meningococcus) in households in the African meningitis belt.MethodsCross-sectional carriage surveys were done in seven African meningitis belt countries (Chad, Ethiopia, Ghana, Mali, Niger, Nigeria, and Senegal) between Aug 1, 2010, and Oct 15, 2012. Meningococcal carriers identified in these surveys and all available people in their households were recruited into this longitudinal cohort study. We took pharyngeal swabs at first visit and took further swabs twice a month for 2 months and then monthly for a further 4 months. We used conventional bacteriological and molecular techniques to identify and characterise meningococci. We estimated the rates of carriage acquisition and recovery using a multi-state Markov model.FindingsMeningococci were isolated from 241 (25%) of 980 members of 133 households in which a carrier had been identified in the cross-sectional survey or at the first household visit. Carriage was detected subsequently in another household member who was not an index carrier in 75 households. Transmission within a household, suggested by detection of a further carrier with the same strain as the index carrier, was found in 52 of these 75 households. Children younger than 5 years were the group that most frequently acquired carriage from other household members. The overall individual acquisition rate was 2·4% (95% CI 1·6–4·0) per month, varying by age and household carriage status. The mean duration of carriage was 3·4 months (95% CI 2·7–4·4).InterpretationIn the African meningitis belt, transmission of meningococci within households is important, particularly for young children, and periods of carriage are usually of short duration.
Keyword: [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases; [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; Meningococcal; MESH: Adolescent; MESH: Adult; MESH: Africa; MESH: Age Factors; MESH: Carrier State; MESH: Child; MESH: Cohort Studies; MESH: Cross-Sectional Studies; MESH: Family Characteristics; MESH: Female; MESH: Humans; MESH: Infant; MESH: Longitudinal Studies; MESH: Male; MESH: Meningitis; MESH: Neisseria meningitidis; Newborn; Preschool
URL: https://hal-riip.archives-ouvertes.fr/pasteur-03238489/document
https://doi.org/10.1016/S2214-109X(16)30244-3
https://hal-riip.archives-ouvertes.fr/pasteur-03238489/file/1-s2.0-S2214109X16302443-main.pdf
https://hal-riip.archives-ouvertes.fr/pasteur-03238489
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2
Primary Progressive Aphasia in the Network of French Alzheimer Plan Memory Centers
In: ISSN: 1387-2877 ; Journal of Alzheimer's Disease ; https://hal-univ-fcomte.archives-ouvertes.fr/hal-03630200 ; Journal of Alzheimer's Disease, IOS Press, 2016, 54 (4), pp.1459-1471. ⟨10.3233/JAD-160536⟩ (2016)
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3
[Determinants of support for dementia patients in general practice: a qualitative approach based on an epidemiological cohort].
In: ISSN: 2115-8789 ; EISSN: 2115-7863 ; Gériatrie et psychologie neuropsychiatrie du vieillissement ; https://www.hal.inserm.fr/inserm-00835637 ; Gériatrie et psychologie neuropsychiatrie du vieillissement, John Libbey Eurotext, 2013, 11 (2), pp.157-67. ⟨10.1684/pnv.2013.0413⟩ (2013)
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4
Failure to reduce drinking and driving in France: a 6-year prospective study in the GAZEL cohort.
In: Addiction/British Journal of Addictions ; https://www.hal.inserm.fr/inserm-00400390 ; Addiction/British Journal of Addictions, 2010, 105 (1), pp.57-61. ⟨10.1111/j.1360-0443.2009.02725.x⟩ (2010)
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5
Age differences in outdated information processing during news reports reading.
In: ISSN: 0361-073X ; EISSN: 1096-4657 ; Experimental Aging Research ; https://hal.archives-ouvertes.fr/hal-00559407 ; Experimental Aging Research, Taylor & Francis, 2010, 36 (4), pp.371-92. ⟨10.1080/0361073X.2010.511962⟩ (2010)
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