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1
Embodied Transcendence in Victorian Novels: A Comparative Study of Select Works by George Eliot and Thomas Hardy
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Rates of amyloid imaging positivity in patients with primary progressive aphasia
In: Santos-Santos, MA; Rabinovici, GD; Iaccarino, L; Ayakta, N; Tammewar, G; Lobach, I; et al.(2018). Rates of amyloid imaging positivity in patients with primary progressive aphasia. JAMA Neurology, 75(3), 342 - 352. doi:10.1001/jamaneurol.2017.4309. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/1hm128x5 (2018)
Abstract: © 2018 American Medical Association. All rights reserved. IMPORTANCE The ability to predict the pathology underlying different neurodegenerative syndromes is of critical importance owing to the advent of molecule-specific therapies. OBJECTIVE To determine the rates of positron emission tomography (PET) amyloid positivity in the main clinical variants of primary progressive aphasia (PPA). DESIGN, SETTING, AND PARTICIPANTS This prospective clinical-pathologic case serieswas conducted at a tertiary research clinic specialized in cognitive disorders. Patients were evaluated as part of a prospective, longitudinal research study between January 2002 and December 2015. Inclusion criteria included clinical diagnosis of PPA; availability of complete speech, language, and cognitive testing; magnetic resonance imaging performed within 6 months of the cognitive evaluation; and PET carbon 11-labeled Pittsburgh Compound-B or florbetapir F 18 brain scan results. Of 109 patients referred for evaluation of language symptoms who underwent amyloid brain imaging, 3 were excluded because of incomplete language evaluations, 5 for absence of significant aphasia, and 12 for presenting with significant initial symptoms outside of the language domain, leaving a cohort of 89 patients with PPA. MAIN OUTCOMES AND MEASURES Clinical, cognitive, neuroimaging, and pathology results. RESULTS Twenty-eight cases were classified as imaging-supported semantic variant PPA (11 women [39.3%]; mean [SD] age, 64 [7] years), 31 nonfluent/agrammatic variant PPA (22 women [71.0%]; mean [SD] age, 68 [7] years), 26 logopenic variant PPA (17 women [65.4%]; mean [SD] age, 63 [8] years), and 4 mixed PPA cases. Twenty-four of 28 patients with semantic variant PPA (86%) and 28 of 31 patients with nonfluent/agrammatic variant PPA (90%) had negative amyloid PET scan results, while 25 of 26 patients with logopenic variant PPA (96%) and 3 of 4 mixed PPA cases (75%) had positive scan results. The amyloid positive semantic variant PPA and nonfluent/agrammatic variant PPA cases with available autopsy data (2 of 4 and 2 of 3, respectively) all had a primary frontotemporal lobar degeneration and secondary Alzheimer disease pathologic diagnoses, whereas autopsy of 2 patients with amyloid PET-positive logopenic variant PPA confirmed Alzheimer disease. One mixed PPA patient with a negative amyloid PET scan had Pick disease at autopsy. CONCLUSIONS AND RELEVANCE Primary progressive aphasia variant diagnosis according to the current classification scheme is associated with Alzheimer disease biomarker status, with the logopenic variant being associated with carbon 11-labeled Pittsburgh Compound-B positivity in more than 95%of cases. Furthermore, in the presence of a clinical syndrome highly predictive of frontotemporal lobar degeneration pathology, biomarker positivity for Alzheimer disease may be associated more with mixed pathology rather than primary Alzheimer disease.
URL: http://www.escholarship.org/uc/item/1hm128x5
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3
Associative agreement as a predictor of naming ability in alzheimer’s disease: A case for the semantic nature of associative links
Zannino, GD; Perri, R; Teghil, A. - : FRONTIERS MEDIA SA, 2018
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4
Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease
In: Bejanin, A; Schonhaut, DR; La Joie, R; Kramer, JH; Baker, SL; Sosa, N; et al.(2017). Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease. Brain, 140(12), 3286 - 3300. doi:10.1093/brain/awx243. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/9ms625vc (2017)
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5
Characterization of hunter-gatherer networks and implications for cumulative culture
In: Nature Human Behaviour , 1 (2) , Article 0043. (2017) (2017)
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6
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease
In: Ossenkoppele, R; Schonhaut, DR; Schöll, M; Lockhart, SN; Ayakta, N; Baker, SL; et al.(2016). Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease. Brain, 139(5), 1551 - 1567. doi:10.1093/brain/aww027. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/99g11755 (2016)
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7
Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.
In: Alzheimers Dement , 12 (3) pp. 292-323. (2016) (2016)
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8
Knowledge-Sharing Networks in Hunter-Gatherers and the Evolution of Cumulative Culture
In: Current Biology , 26 (18) pp. 2516-2521. (2016) (2016)
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9
Beginning at the Beginning: Recall Order and the Number of Words to Be Recalled.
Tan, L; Ward, GD; Paulauskaite, L. - : American Psychological Association, 2016
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10
Defining the Effect of the 16p11.2 Duplication on Cognition, Behavior, and Medical Comorbidities.
In: Jama Psychiatry, vol. 73, no. 1, pp. 20-30 (2016)
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11
Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease
In: Ossenkoppele, R; Cohn-Sheehy, BI; La Joie, R; Vogel, JW; Möller, C; Lehmann, M; et al.(2015). Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease. Human Brain Mapping, 36(11), 4421 - 4437. doi:10.1002/hbm.22927. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/9751k10x (2015)
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12
Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer's disease variants
In: Neurobiology of Aging, vol 36, iss 10 (2015)
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13
Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer's disease variants
In: Lehmann, M; Madison, C; Ghosh, PM; Miller, ZA; Greicius, MD; Kramer, JH; et al.(2015). Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer's disease variants. Neurobiology of Aging, 36(10), 2678 - 2686. doi:10.1016/j.neurobiolaging.2015.06.029. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/28q4h46t (2015)
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14
Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer's disease variants
In: Neurobiology of Aging, vol 36, iss 10 (2015)
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15
Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer's disease variants.
In: Neurobiol Aging , 36 (10) pp. 2678-2686. (2015) (2015)
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16
Differential Diagnosis of Speech Sound Disorder (Phonological Disorder): Audiological Assessment beyond the Pure-tone Audiogram.
In: J Am Acad Audiol , 26 (4) 423 - 435. (2015) (2015)
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17
Measurement of the muon reconstruction performance of the ATLAS detector using 2011 and 2012 LHC proton-proton collision data.
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2014)
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18
Observation of $Z$ production in proton-lead collisions at LHCb
In: Symplectic Elements at Oxford ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; ArXiv (http://arxiv.org/) (2014)
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19
Parallel ICA of FDG-PET and PiB-PET in three conditions with underlying Alzheimer's pathology.
In: Neuroimage Clin , 4 pp. 508-516. (2014) (2014)
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20
Common variation near ROBO2 is associated with expressive vocabulary in infancy
In: NATURE COMMUNICATIONS , 5 (ARTN 483) (2014) (2014)
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