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projectEndings/staticSearch: v1.1.0 (Second Production Release) ...
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Low fundamental and formant frequencies predict fighting ability among male mixed martial arts fighters
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In: Sci Rep (2021)
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(Re)creating modern languages: conversations about the curriculum in UK higher education
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Improving knowledge of text neck and neck pain using interactive smartphone application for undergraduate students in Universiti Sains Malaysia
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Türkische Migration und die Entwicklung des deutschen Slangs. Inwiefern hat türkische Migration das Verständnis des türkischen Slangs in der deutschen Sprache verbreitet?
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DNB Subject Category Language
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Türkische Migration und die Entwicklung des deutschen Slangs. Inwiefern hat türkische Migration das Verständnis des türkischen Slangs in der deutschen Sprache verbreitet?
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DNB Subject Category Language
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Measurement of $W^{\pm}$-boson and $Z$-boson production cross-sections in $pp$ collisions at $\sqrt{s}=2.76$ TeV with the ATLAS detector
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Overview of ImageCLEF 2018: challenges, datasets and evaluation
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In: Ionescu, Bogdan orcid:0000-0003-4112-5769 , Müller, Mauricio, García Seco de Herrera, Alba orcid:0000-0002-6509-5325 , Eickhoff, Carsten, Dicente Cid, Yashin, Andrearczyk, Vincent, Liauchuk, Vitali, Kovalev, Vassili, Hasan, Sadid A., Ling, Yuan, Farri, Oladimeji, Liu, Joey, Lungren, Matthew, Dang-Nguyen, Duc-Tien orcid:0000-0002-2761-2213 , Piras, Luca, Riegler, Michael, Zhou, Liting orcid:0000-0002-7778-8743 , Lux, Mathias and Gurrin, Cathal orcid:0000-0003-2903-3968 (2018) Overview of ImageCLEF 2018: challenges, datasets and evaluation. In: ImageCLEF 2018: Experimental IR Meets Multilinguality, Multimodality, and Interaction. ISBN 978-3-319-98932-7 (2018)
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Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.
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Savage, Jeanne E; Jansen, Philip R; Stringer, Sven; Watanabe, Kyoko; Bryois, Julien; de Leeuw, Christiaan A; Nagel, Mats; Awasthi, Swapnil; Barr, Peter B; Coleman, Jonathan RI; Grasby, Katrina L; Hammerschlag, Anke R; Kaminski, Jakob A; Karlsson, Robert; Krapohl, Eva; Lam, Max; Nygaard, Marianne; Reynolds, Chandra A; Trampush, Joey W; Young, Hannah; Zabaneh, Delilah; Hägg, Sara; Hansell, Narelle K; Karlsson, Ida K; Linnarsson, Sten; Montgomery, Grant W; Muñoz-Manchado, Ana B; Quinlan, Erin B; Schumann, Gunter; Skene, Nathan G; Webb, Bradley T; White, Tonya; Arking, Dan E; Avramopoulos, Dimitrios; Bilder, Robert M; Bitsios, Panos; Burdick, Katherine E; Cannon, Tyrone D; Chiba-Falek, Ornit; Christoforou, Andrea; Cirulli, Elizabeth T; Congdon, Eliza; Corvin, Aiden; Davies, Gail; Deary, Ian J; DeRosse, Pamela; Dickinson, Dwight; Djurovic, Srdjan; Donohoe, Gary; Conley, Emily Drabant; Eriksson, Johan G; Espeseth, Thomas; Freimer, Nelson A; Giakoumaki, Stella; Giegling, Ina; Gill, Michael; Glahn, David C; Hariri, Ahmad R; Hatzimanolis, Alex; Keller, Matthew C; Knowles, Emma; Koltai, Deborah; Konte, Bettina; Lahti, Jari; Le Hellard, Stephanie; Lencz, Todd; Liewald, David C; London, Edythe; Lundervold, Astri J; Malhotra, Anil K; Melle, Ingrid; Morris, Derek; Need, Anna C; Ollier, William; Palotie, Aarno; Payton, Antony; Pendleton, Neil; Poldrack, Russell A; Räikkönen, Katri; Reinvang, Ivar; Roussos, Panos; Rujescu, Dan; Sabb, Fred W; Scult, Matthew A; Smeland, Olav B; Smyrnis, Nikolaos; Starr, John M; Steen, Vidar M; Stefanis, Nikos C; Straub, Richard E; Sundet, Kjetil; Tiemeier, Henning; Voineskos, Aristotle N; Weinberger, Daniel R; Widen, Elisabeth; Yu, Jin; Abecasis, Goncalo; Andreassen, Ole A; Breen, Gerome; Christiansen, Lene
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In: Nature genetics, vol 50, iss 7 (2018)
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Abstract:
Intelligence is highly heritable1 and a major determinant of human health and well-being2. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in intelligence3-7, but much about its genetic underpinnings remains to be discovered. Here, we present a large-scale genetic association study of intelligence (n = 269,867), identifying 205 associated genomic loci (190 new) and 1,016 genes (939 new) via positional mapping, expression quantitative trait locus (eQTL) mapping, chromatin interaction mapping, and gene-based association analysis. We find enrichment of genetic effects in conserved and coding regions and associations with 146 nonsynonymous exonic variants. Associated genes are strongly expressed in the brain, specifically in striatal medium spiny neurons and hippocampal pyramidal neurons. Gene set analyses implicate pathways related to nervous system development and synaptic structure. We confirm previous strong genetic correlations with multiple health-related outcomes, and Mendelian randomization analysis results suggest protective effects of intelligence for Alzheimer's disease and ADHD and bidirectional causation with pleiotropic effects for schizophrenia. These results are a major step forward in understanding the neurobiology of cognitive function as well as genetically related neurological and psychiatric disorders.
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Keyword:
Adolescent; Biological Sciences; Brain; Developmental Biology; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Intelligence; Male; Medical and Health Sciences; Middle Aged; Polymorphism; Quantitative Trait Loci; Single Nucleotide
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URL: https://escholarship.org/uc/item/869275xx
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Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).
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In: Twin research and human genetics : the official journal of the International Society for Twin Studies, vol 21, iss 5 (2018)
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Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
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The spectator's gaze : between pleasure and danger : the work of art in Siri Hustvedt's novel ; Jeux et enjeux du regard : entre plaisir et danger : l’œuvre d’art dans le roman de Siri Hustvedt
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In: https://tel.archives-ouvertes.fr/tel-01761236 ; Linguistique. Université de la Réunion, 2017. Français. ⟨NNT : 2017LARE0028⟩ (2017)
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Informed consent ; bva005 ; Recording and archiving Barayin (Jalkiya) language data
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Circumcision ; bva003 ; Recording and archiving Barayin (Jalkiya) language data
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