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Sporadic Jakob-Creutzfeldt disease presenting as primary progressive aphasia.
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In: JAMA neurology, vol 70, iss 2 (2013)
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Sporadic Jakob-Creutzfeldt disease presenting as primary progressive aphasia.
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Johnson, David Y; Dunkelberger, Diana L; Henry, Maya; Haman, Aissatou; Greicius, Michael D; Wong, Katherine; DeArmond, Stephen J; Miller, Bruce L; Gorno-Tempini, Maria Luisa; Geschwind, Michael D
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In: JAMA neurology, vol 70, iss 2 (2013)
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Abstract:
ObjectiveTo report the clinical, neuropsychological, linguistic, imaging, and neuropathological features of a unique case of sporadic Jakob-Creutzfeldt disease in which the patient presented with a logopenic variant of primary progressive aphasia.DesignCase report.SettingLarge referral center for atypical memory and aging disorders, particularly Jakob-Creutzfeldt disease.PatientPatient presenting with logopenic variant primary progressive aphasia initially thought to be due to Alzheimer disease.ResultsDespite the long, slow 3.5-year course, the patient was shown to have pathology-proven sporadic Jakob-Creutzfeldt disease.ConclusionsThese findings expand the differential of primary progressive aphasia to include prion disease.
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Keyword:
Aphasia; Creutzfeldt-Jakob Syndrome; Diagnosis; Differential; Humans; Male; Middle Aged; Neuropsychological Tests; Primary Progressive
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URL: https://escholarship.org/uc/item/2bb0c39w
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Sporadic Jakob-Creutzfeldt Disease Presenting as Primary Progressive Aphasia
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