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Structural, Microstructural, and Metabolic Alterations in Primary Progressive Aphasia Variants
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In: ISSN: 1664-2295 ; Frontiers in Neurology ; https://hal.inria.fr/hal-01897015 ; Frontiers in Neurology, Frontiers, 2018, 9, ⟨10.3389/fneur.2018.00766⟩ (2018)
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Structural, microstructural and metabolic alterations in Primary Progressive Aphasia variants
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In: Annual meeting of the Organization for Human Brain Mapping - OHBM 2018 ; https://hal.inria.fr/hal-01764289 ; Annual meeting of the Organization for Human Brain Mapping - OHBM 2018, Jun 2018, Singapore, Singapore (2018)
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Structural, Microstructural, and Metabolic Alterations in Primary Progressive Aphasia Variants
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Pauses During Autobiographical Discourse Reflect Episodic Memory Processes in Early Alzheimer’s Disease
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Pistono, Aurélie; Jucla, Mélanie; Barbeau, Emmanuel J.; Saint-Aubert, Laure; Lemesle, Béatrice; Calvet, Benjamin; Köpke, Barbara; Puel, Michèle; Pariente, Jérémie. - : IOS Press, 2016
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Abstract:
There is a large body of research on discourse production in Alzheimer’s disease (AD). Some studies have focused on pause production, revealing that patients make extensive use of pauses during speech. This has been attributed to lexical retrieval difficulties, but pausing may also reflect other forms of cognitive impairment as it increases with cognitive load. The aim of the present study was to analyze autobiographical discourse impairment in AD from a broad perspective, looking at pausing behavior (frequency, duration, and location). Our first objective was to characterize discourse changes in mild cognitive impairment (MCI) due to AD. Our second objective was to determine the cognitive and neuroanatomical correlates of these changes. Fifteen patients with MCI due to AD and 15 matched cognitively normal controls underwent an ecological episodic memory task, a full neuropsychological assessment, and a 3D T1-weighted MRI scans. Autobiographical discourse collected from the ecological episodic memory task was recorded, transcribed, and analyzed, focusing on pausing. Intergroup comparisons showed that although patients did not produce more pauses than controls overall, they did make more between-utterance pauses. The number of these specific pauses was positively correlated with patients’ episodic memory performance. Furthermore, neuroimaging analysis showed that, in the patient group, their use was negatively correlated with frontopolar area (BA 10) grey matter density. This region may therefore play an important role in the planning of autobiographical discourse production. These findings demonstrate that pauses in early AD may reflect a compensatory mechanism for improving mental time travel and memory retrieval.
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Keyword:
Research Article
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URL: http://www.ncbi.nlm.nih.gov/pubmed/26757034
https://doi.org/10.3233/JAD-150408
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927846/
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Proper name anomia with preserved lexical and semantic knowledge after left anterior temporal lesion: A two-way convergence defect
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In: ISSN: 0010-9452 ; Cortex ; https://hal.archives-ouvertes.fr/hal-02344887 ; Cortex, Elsevier, 2015, 65, pp.1-18. ⟨10.1016/j.cortex.2014.12.008⟩ (2015)
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Good recovery from aphasia is also supported by right basal ganglia: a longitudinal controlled PET study. EJPRM-ESPRM 2008 award winner.
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In: Eur J Phys Rehabil Med ; https://www.hal.inserm.fr/inserm-00443753 ; Eur J Phys Rehabil Med, 2009, 45 (4), pp.547-58 (2009)
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[Functional neuroimaging and the treatment of aphasia: speech therapy and repetitive transcranial magnetic stimulation]
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In: ISSN: 0035-3787 ; Revue Neurologique ; https://www.hal.inserm.fr/inserm-00349534 ; Revue Neurologique, Elsevier Masson, 2008, 164 Suppl 3, pp.S45-8. ⟨10.1016/S0035-3787(08)73290-9⟩ (2008)
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