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Syntactic and Semantic Specialization and Integration in 5- to 6-Year-Old Children during Auditory Sentence Processing
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Family-based genetic investigation of SLI (Andres et al., 2020) ...
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Family-based genetic investigation of SLI (Andres et al., 2020) ...
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2019 ASHA Research Symposium: Mabel L. Rice, Panel Discussion on Specific Language Impairment ...
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2019 ASHA Research Symposium: Mabel L. Rice, What Studies of Twins Tell Us About Specific Language Impairment in Children: Twinning Effects & Heritability at 2, 4, 6, and 16 Years of Age ...
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2019 ASHA Research Symposium: Mabel L. Rice, Panel Discussion on Specific Language Impairment ...
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2019 ASHA Research Symposium: Mabel L. Rice, Panel Discussion on Specific Language Impairment ...
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2019 ASHA Research Symposium: Mabel L. Rice, What Studies of Twins Tell Us About Specific Language Impairment in Children: Twinning Effects & Heritability at 2, 4, 6, and 16 Years of Age ...
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2019 ASHA Research Symposium: Mabel L. Rice, What Studies of Twins Tell Us About Specific Language Impairment in Children: Twinning Effects & Heritability at 2, 4, 6, and 16 Years of Age ...
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Causal Pathways for Specific Language Impairment: Lessons From Studies of Twins
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In: J Speech Lang Hear Res (2020)
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Abstract:
PURPOSE: This review article summarizes a program of longitudinal investigation of twins' language acquisition with a focus on causal pathways for specific language impairment (SLI) and nonspecific language impairment in children at 4 and 6 years with known history at 2 years. METHOD: The context of the overview is established by legacy scientific papers in genetics, language, and SLI. Five recent studies of twins are summarized, from 2 to 16 years of age, with a longitudinal perspective of heritability over multiple speech, language, and cognitive phenotypes. RESULTS: Replicated moderate-to-high heritability is reported across ages, phenotypes, full population estimates, and estimates for clinical groups. Key outcomes are documentation of a twinning effect of risk for late language acquisition in twins that persists through 6 years of age, greater for monozygotic than dizygotic twins (although zygosity effects disappear at 6 years); heritability is greater for grammar and morphosyntax than other linguistic dimensions, from age 2 years through age 16 years, replicated within twin samples at subsequent age levels and across twin samples at age 16 years. CONCLUSION: There is consistent support for legacy models of genetic influences on language acquisition, updated with a more precise growth signaling disruption model supported by twin data, as well as singleton data of children with SLI and nonspecific language impairment. PRESENTATION VIDEO: https://doi.org/10.23641/asha.13063727
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Forum: Advances in Specific Language Impairment Research & Intervention
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URL: https://doi.org/10.1044/2020_JSLHR-20-00169 http://www.ncbi.nlm.nih.gov/pubmed/33064600 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062132/
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Pedigree-Based Gene Mapping Supports Previous Loci and Reveals Novel Suggestive Loci in Specific Language Impairment
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In: J Speech Lang Hear Res (2020)
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Advances in Specific Language Impairment Research and Intervention: An Overview of Five Research Symposium Papers
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In: J Speech Lang Hear Res (2020)
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Heritability of Specific Language Impairment and Nonspecific Language Impairment at Ages 4 and 6 Years Across Phenotypes of Speech, Language, and Nonverbal Cognition
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In: J Speech Lang Hear Res (2020)
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Birth Prevalence of Congenital Cytomegalovirus Infection in HIV-Exposed Uninfected Children in the Era of Combination Antiretroviral Therapy
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In: J Pediatr (2019)
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Prenatal and perinatal risks for late language emergence in a population-level sample of twins at age 2
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Grammar Clinical Marker Yields Substantial Heritability for Language Impairments in 16-Year-Old Twins
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Risk for Speech and Language Impairments in Pre-school Aged HIV-Exposed Uninfected Children with in utero Combination Antiretroviral Exposure
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Mapping Chromosomal Loci in Specific Language Impairment: A Pedigree-Focused Approach
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Effects of Language Context on Ratings of Shy and Unsociable Behaviors in English Language Learning Children
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