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Preliminary result of the "origins of speech" project
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In: UISPP 2021 - XIXth World Congress of the International Union of the Prehistoric and Protohistoric Sciences (UISPP'2021) ; https://hal.archives-ouvertes.fr/hal-03357948 ; UISPP 2021 - XIXth World Congress of the International Union of the Prehistoric and Protohistoric Sciences (UISPP'2021), Sep 2021, Meknes, Morocco ; https://uispp2020.sciencesconf.org/367310 (2021)
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Corpus callosum morphology across the lifespan in baboons (Papio anubis): A cross-sectional study of relative mid-sagittal surface area and thickness
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In: ISSN: 0168-0102 ; EISSN: 1872-8111 ; Neuroscience Research ; https://hal-amu.archives-ouvertes.fr/hal-03196956 ; Neuroscience Research, Elsevier, 2021, ⟨10.1016/j.neures.2021.03.002⟩ (2021)
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A Conserved uORF Regulates APOBEC3G Translation and Is Targeted by HIV-1 Vif Protein to Repress the Antiviral Factor
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Libre, Camille; Seissler, Tanja; Guerrero, Santiago; Batisse, Julien; Verriez, Cédric; Stupfler, Benjamin; Gilmer, Orian; Cabrera-Rodriguez, Romina; Weber, Melanie,; Valenzuela-Fernandez, Agustin; Cimarelli, Andrea; Etienne, Lucie; Marquet, Roland; Paillart, Jean-Christophe
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In: ISSN: 2227-9059 ; Biomedicines ; https://hal.archives-ouvertes.fr/hal-03519994 ; Biomedicines, MDPI, 2021, 10 (1), pp.13. ⟨10.3390/biomedicines10010013⟩ (2021)
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Abstract:
International audience ; The HIV-1 Vif protein is essential for viral fitness and pathogenicity. Vif decreases expression of cellular restriction factors APOBEC3G (A3G), A3F, A3D and A3H, which inhibit HIV-1 replication by inducing hypermutation during reverse transcription. Vif counteracts A3G at several levels (transcription, translation, and protein degradation) that altogether reduce the levels of A3G in cells and prevent its incorporation into viral particles. How Vif affects A3G translation remains unclear. Here, we uncovered the importance of a short conserved uORF (upstream ORF) located within two critical stem-loop structures of the 5′ untranslated region (5′-UTR) of A3G mRNA for this process. A3G translation occurs through a combination of leaky scanning and translation re-initiation and the presence of an intact uORF decreases the extent of global A3G translation under normal conditions. Interestingly, the uORF is also absolutely required for Vif-mediated translation inhibition and redirection of A3G mRNA into stress granules. Overall, we discovered that A3G translation is regulated by a small uORF conserved in the human population and that Vif uses this specific feature to repress its translation
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Keyword:
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases; [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology; APOBEC3G; HIV-1; Molecular Biology/Genomics [q-bio.GN]; mRNA; translation; uORF; Vif
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URL: https://hal.archives-ouvertes.fr/hal-03519994/file/Paillart%20-%20A%20Conserved%20uORF%20Regulates%20APOBEC3G%20Translation%20and%20Is%20Targeted%20by%20HIV-1%20Vif%20Protein%20to%20Repress%20the%20Antiviral%20Factor.pdf
https://doi.org/10.3390/biomedicines10010013
https://hal.archives-ouvertes.fr/hal-03519994/document
https://hal.archives-ouvertes.fr/hal-03519994
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Constructing Antidictionaries of Long Texts in Output-Sensitive Space
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Early Left-Planum Temporale Asymmetry in newborn monkeys (Papio anubis): A longitudinal structural MRI study at two stages of development
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In: ISSN: 1053-8119 ; EISSN: 1095-9572 ; NeuroImage ; https://hal.archives-ouvertes.fr/hal-03086011 ; NeuroImage, Elsevier, 2021, 227, pp.117575. ⟨10.1016/j.neuroimage.2020.117575⟩ (2021)
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Early Left-Planum Temporale Asymmetry in newborn monkeys (Papio anubis): A longitudinal structural MRI study at two stages of development
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In: ISSN: 1053-8119 ; EISSN: 1095-9572 ; NeuroImage ; https://hal.archives-ouvertes.fr/hal-03086011 ; NeuroImage, Elsevier, 2021, 227, pp.117575. ⟨10.1016/j.neuroimage.2020.117575⟩ (2021)
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Planum Temporale grey matter volume asymmetries in new-born monkeys (Papio anubis)
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In: ISSN: 1863-2653 ; EISSN: 1863-2661 ; Brain Structure and Function ; https://hal-amu.archives-ouvertes.fr/hal-03196979 ; Brain Structure and Function, Springer Verlag, 2021, ⟨10.1007/s00429-021-02278-9⟩ (2021)
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Evaluating Multilingual Text Encoders for Unsupervised Cross-Lingual Retrieval ...
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Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia
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In: ISSN: 1359-4184 ; EISSN: 1476-5578 ; Molecular Psychiatry ; https://hal.archives-ouvertes.fr/hal-02976104 ; Molecular Psychiatry, Nature Publishing Group, 2020, ⟨10.1038/s41380-020-00898-x⟩ (2020)
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Consensus on a video analysis framework of descriptors and definitions by the Rugby Union Video Analysis Consensus group
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Initial assessment of the early arthritis for psoriatic patients diagnostic questionnaire in dermatology clinics in Australia, Korea and China.
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Multilingual and cross-lingual graded lexical entailment ...
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Multilingual and cross-lingual graded lexical entailment
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Vulic, Ivan; Ponzetto, SP; Glavaš, G. - : Association for Computational Linguistics, 2019. : ACL 2019 - 57th Annual Meeting of the Association for Computational Linguistics, Proceedings of the Conference, 2019
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Speech therapy intervention in an interdisciplinary therapeutic educational group : an enunciation space
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UMA ARMA NA MÃO E JESUS NO CORAÇÃO: CIRCULAÇÃO E ASPECTOS FORMULAICOS DO SINTAGMA 'CIDADÃO DE BEM'
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In: VERBUM. CADERNOS DE PÓS-GRADUAÇÃO. ISSN 2316-3267; v. 8, n. 3 (2019): Dossiê Análise do Discurso de linha francesa: perspectivas enunciativo-discursivas; 78-98 ; 2316-3267 (2019)
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A SUSTENTABILIDADE À LUZ DA ACD
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In: VERBUM. CADERNOS DE PÓS-GRADUAÇÃO. ISSN 2316-3267; v. 7, n. 2 (2018): Dossiê: Teorias Sociais de Linguagem; 80-102 ; 2316-3267 (2018)
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ENSINO DE PORTUGUÊS LINGUA ESTRANGEIRA E A PRODUÇÃO DE MATERIAL DIDÁTICO AUTÊNTICO: AULAS GUIADAS
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In: VERBUM. CADERNOS DE PÓS-GRADUAÇÃO. ISSN 2316-3267; v. 7, n. 3 (2018): DOSSIÊ: PORTUGUÊS LÍNGUA ESTRANGEIRA; 06-15 ; 2316-3267 (2018)
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Linking shyness to social anxiety in children through the Clark and Wells cognitive model
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