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Neural substrates of verbal repetition deficits in primary progressive aphasia.
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| 2 |
Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
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In: MDPI (2021)
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Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
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In: Multidisciplinary Digital Publishing Institute (2021)
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A category-selective semantic memory deficit for animate objects in semantic variant primary progressive aphasia
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In: Brain Commun (2021)
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Neural substrates of verbal repetition deficits in primary progressive aphasia
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In: Brain Commun (2021)
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Differential Diagnosis of Apraxia of Speech in Children and Adults: A Scoping Review
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In: Speech Pathology and Audiology Faculty Research and Publications (2020)
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| 7 |
Differential Diagnosis of Apraxia of Speech in Children and Adults: A Scoping Review
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In: J Speech Lang Hear Res (2020)
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| 8 |
Quantitative assessment of motor speech impairment in primary progressive aphasia
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Abstract:
Primary progressive aphasia is a neurodegenerative aphasic syndrome that can be classified into three main variants: agrammatic/non-fluent (nfvPPA), logopenic (lvPPA), and semantic (svPPA). Motor speech impairment is a key diagnostic marker used to aid classification of the clinical variants of PPA. Identification of motor speech symptoms is useful not only for differential diagnosis of PPA subtypes but may also inform hypotheses related to anatomic localization of disease and underlying pathophysiologic mechanisms. However, the diagnosis and characterization of motor speech impairment poses unique challenges when applied to the PPA population. First, motor speech impairment must be differentiated from comorbid language impairment and second—upon identification of a motor speech impairment—a disorder of motor planning (i.e., apraxia of speech) must be differentiated from one of motor execution (i.e., dysarthria). The proposed series of acoustic, kinematic, and imaging-based analyses were designed to assess the diagnostic efficacy and biological validity of quantitative speech measures for identifying motor speech impairment in PPA, and to determine if motor speech impairments in PPA are consistent with apraxia of speech and/or dysarthria. In Study 1, we investigate the diagnostic accuracy of quantitative measures of speech rate as compared to clinician-rated measures to identify nfvPPA (cf. lvPPA, svPPA). Study 1 results provide evidence that an articulation rate (AR) measure may be a useful quantitative proxy of motor speech impairment. Study 2 extends this finding and evaluates whether the AR measure sensitively detects very mild motor speech impairment in PPA, and whether the AR measure is responsive to longitudinal changes in motor speech function. We also investigate the neuroanatomical basis of motor speech impairment in PPA by relating the AR measure to cortical thickness in motor speech regions of interest. Lastly, in Study 3, we go beyond mere identification of motor speech impairment and seek to characterize individual profiles of motor speech impairment—with specific reference to apraxic and dysarthric features—using acoustic and kinematic measures of motor speech function. Results of the study series are interpreted in light of potential contributions to (1) diagnostic subtyping, (2) clinical monitoring, and (3) development of speech motor outcome measures. ; Medical Sciences
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Keyword:
motor speech; primary progressive aphasia
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URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41121321
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Table e-3. Operational guidelines for motor speech severity ratings ...
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Table e-4. Motor speech features and criteria for diagnosing AOS, Dysarthria ...
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Figure e-1. Motor speech regions of interest labelled using SpeechLabel parcellation paradigm ...
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| 12 |
Data from: Quantification of motor speech impairment and its anatomic basis in primary progressive aphasia ...
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Table e-1. Baseline speech/language characteristics per patient ...
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Table e-2. Supplemental CDR language domain as defined by Knopman, Weintraub, and Pankratz (2011) ...
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Table e-5. Motor speech characterizations (consensus ratings) per patient ...
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Quantification of motor speech impairment and its anatomic basis in primary progressive aphasia
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Slowed articulation rate is a sensitive diagnostic marker for identifying non-fluent primary progressive aphasia
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