| 1 |
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 2 |
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
|
|
|
|
In: Translational Psychiatry, 9 (1) (2019)
|
|
BASE
|
|
Show details
|
|
|
| 3 |
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
|
|
|
|
BASE
|
|
Show details
|
|
|
| 4 |
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
|
|
|
|
BASE
|
|
Show details
|
|
|
| 5 |
The neuronal migration hypothesis of dyslexia: A critical evaluation 30 years on
|
|
|
|
BASE
|
|
Show details
|
|
|
| 6 |
The neuronal migration hypothesis of dyslexia: A critical evaluation 30 years on
|
|
|
|
BASE
|
|
Show details
|
|
|
| 7 |
Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
|
|
|
|
BASE
|
|
Show details
|
|
|
| 8 |
Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
|
|
Pettigrew, Kerry Andrea; Frinton, Emily; Nudel, Ron; Chan, May T. M.; Thompson, Paul; Hayiou-Thomas, Marianna E.; Talcott, Joel B.; Stein, John; Monaco, Anthony P.; Hulme, Charles; Snowling, Margaret J.; Newbury, Diane F.; Paracchini, Silvia. - 2016
|
|
Abstract:
SP is a Royal Society University Research Fellow. Support to the analysis was provided by the St Andrews Bioinformatics Unit funded by the Wellcome Trust [grant 097831/Z/11/Z]. Analysis of the cohort was supported by a Wellcome Trust Programme Grant to MJS [WT082032MA]. EF is the recipient of a Wolfson Intercalated Award. MTMC is the recipient of the Wilkinson Junior Research Fellowship at Worcester College, Oxford and was funded by the Esther Yewpick Lee Millennium Scholarship. RN was funded by a University of Oxford Nuffield Department of Medicine Prize Studentship. DFN is an MRC Career Development Fellow. The work of the Newbury lab is funded by the Medical Research Council [G1000569/1 and MR/J003719/1]. The work of the Wellcome Trust Centre in Oxford is supported by the Wellcome Trust [090532/Z/09/Z]. ; Background: Specific Language Impairment (SLI) is a common neurodevelopmental disorder, observed in 5-10% of children. Family and twin studies suggest a strong genetic component, but relatively few candidate genes have been reported to date. A recent genome-wide association study (GWAS) described the first statistically significant association specifically for a SLI cohort between a missense variant (rs4280164) in the NOP9 gene and language-related phenotypes under a parent-of-origin model. Replications of these findings are particularly challenging because the availability of parental DNA is required. Methods: We used two independent family-based cohorts characterised with reading- and language-related traits: a longitudinal cohort (n = 106 informative families) including children with language and reading difficulties and a nuclear family cohort (n = 264 families) selected for dyslexia. Results: We observed association with languagerelated measures when modelling for parent-of-origin effects at the NOP9 locus in both cohorts: minimum P = 0.001 for phonological awareness with a paternal effect in the first cohort and minimum P = 0.0004 for irregular word reading with a maternal effect in the second cohort. Allelic and parental trends were not consistent when compared to the original study. Conclusions: A parent-of-origin effect at this locus was detected in both cohorts, albeit with different trends. These findings contribute in interpreting the original GWAS report and support further investigations of the NOP9 locus and its role in language-related traits. A systematic evaluation of parent-of-origin effects in genetic association studies has the potential to reveal novel mechanisms underlying complex traits. ; Publisher PDF ; Peer reviewed
|
|
Keyword:
Candidate gene; Dyslexia; Genetic association; Language impairement; NDAS; Parent-of-origin; RC0321; RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
|
|
URL: http://hdl.handle.net/10023/8991
https://doi.org/10.1186/s11689-016-9157-6
|
|
BASE
|
|
Hide details
|
|
|
| 9 |
Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
|
|
|
|
BASE
|
|
Show details
|
|
|
| 10 |
Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
|
|
|
|
BASE
|
|
Show details
|
|
|
| 11 |
Genome-wide screening for DNA variants associated with reading and language traits
|
|
|
|
BASE
|
|
Show details
|
|
|
| 12 |
Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
|
|
|
|
BASE
|
|
Show details
|
|
|
| 13 |
Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment
|
|
|
|
BASE
|
|
Show details
|
|
|
| 14 |
Reading and language disorders : the importance of both quantity and quality
|
|
|
|
BASE
|
|
Show details
|
|
|
| 15 |
Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
|
|
|
|
BASE
|
|
Show details
|
|
|
| 16 |
Associations of HLA alleles with specific language impairment
|
|
|
|
BASE
|
|
Show details
|
|
|
| 17 |
Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
|
|
|
|
BASE
|
|
Show details
|
|
|
| 18 |
Associations of HLA alleles with specific language impairment
|
|
|
|
BASE
|
|
Show details
|
|
|
| 19 |
Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
|
|
|
|
BASE
|
|
Show details
|
|
|
| 20 |
Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort.
|
|
|
|
In: ISSN: 1018-4813 ; EISSN: 1476-5438 ; European Journal of Human Genetics ; https://hal.archives-ouvertes.fr/hal-00964958 ; European Journal of Human Genetics, Nature Publishing Group, 2013, epub ahead of print. ⟨10.1038/ejhg.2013.199⟩ (2013)
|
|
BASE
|
|
Show details
|
|
|
|
|
