| 1 |
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 2 |
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
|
|
|
|
In: Translational Psychiatry, 9 (1) (2019)
|
|
BASE
|
|
Show details
|
|
|
| 3 |
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
|
|
|
|
BASE
|
|
Show details
|
|
|
| 4 |
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
|
|
|
|
BASE
|
|
Show details
|
|
|
| 5 |
The neuronal migration hypothesis of dyslexia: A critical evaluation 30 years on
|
|
|
|
BASE
|
|
Show details
|
|
|
| 6 |
The neuronal migration hypothesis of dyslexia: A critical evaluation 30 years on
|
|
|
|
BASE
|
|
Show details
|
|
|
| 7 |
Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
|
|
|
|
BASE
|
|
Show details
|
|
|
| 8 |
Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
|
|
|
|
BASE
|
|
Show details
|
|
|
| 9 |
Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
|
|
|
|
BASE
|
|
Show details
|
|
|
| 10 |
Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
|
|
|
|
BASE
|
|
Show details
|
|
|
| 11 |
Genome-wide screening for DNA variants associated with reading and language traits
|
|
|
|
BASE
|
|
Show details
|
|
|
| 12 |
Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
|
|
|
|
BASE
|
|
Show details
|
|
|
| 13 |
Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment
|
|
Nudel, Ron; Simpson, Nuala H; Baird, Gillian; O'Hare, Anne; Conti-Ramsden, Gina; Bolton, Patrick F; Hennessy, Elizabeth R; Ring, Susan M; Smith, George Davey; Francks, Clyde; Paracchini, Silvia; Monaco, Anthony P; Fisher, Simon E; Newbury, Dianne F; The SLI Consortium. - 2015
|
|
Abstract:
Dianne Newbury is an MRC Career Development Fellow and a Junior Research Fellow at St John’s College, University of Oxford. The work of the Newbury lab is funded by the Medical Research Council [G1000569/1 and MR/J003719/1]. Ron Nudel is funded by a University of Oxford Nuffield Department of Medicine Prize Studentship. The genotyping of samples was funded by the Max Planck Society. Silvia Paracchini is a Royal Society University Research Fellow. The analyses of the ALSPAC cohort were supported by a grant from the Medical Research Council [G0800523/86473]. The collection of the SLIC samples was supported by the Wellcome Trust (060774 and 076566). Patrick Bolton is supported by a National Institute of Health Research (UK) Senior Investigator award and the Biomedical Research Centre in Mental Health at the South London & Maudsley NHS Trust Hospital, London. The work of the Wellcome Trust Centre in Oxford is supported by the Wellcome Trust [090532/Z/09/Z]. ; Specific language impairment (SLI) is a neurodevelopmental disorder that affects linguistic abilities when development is otherwise normal. We report the results of a genome-wide association study of SLI which included parent-of-origin effects and child genotype effects and used 278 families of language-impaired children. The child genotype effects analysis did not identify significant associations. We found genome-wide significant paternal parent-of-origin effects on chromosome 14q12 (P = 3.74 × 10-8 ) and suggestive maternal parent-of-origin-effects on chromosome 5p13 (P = 1.16 × 10-7 ). A subsequent targeted association of six single-nucleotide-polymorphisms (SNPs) on chromosome 5 in 313 language-impaired individuals from the ALSPAC cohort replicated the maternal effects, albeit in the opposite direction (P = 0.001); as fathers' genotypes were not available in the ALSPAC study, the replication analysis did not include paternal parent-of-origin effects. The paternally-associated SNP on chromosome 14 yields a non-synonymous coding change within the NOP9 gene. This gene encodes an RNA-binding protein that has been reported to be significantly dysregulated in individuals with schizophrenia. The region of maternal association on chromosome 5 falls between the PTGER4 and DAB2 genes, in a region previously implicated in autism and ADHD. The top SNP in this association locus is a potential expression QTL of ARHGEF19 (also called WGEF) on chromosome 1. Members of this protein family have been implicated in intellectual disability. In sum, this study implicates parent-of-origin effects in language impairment, and adds an interesting new dimension to the emerging picture of shared genetic etiology across various neurodevelopmental disorders. ; Publisher PDF ; Peer reviewed
|
|
Keyword:
ALSPAC; GWAS; Imprinting; Neurodevelopmental disorder; QH426; QH426 Genetics; RC0321; RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry; Specific language impairment
|
|
URL: https://doi.org/10.1111/gbb.12127
http://hdl.handle.net/10023/7888
|
|
BASE
|
|
Hide details
|
|
|
| 14 |
Reading and language disorders : the importance of both quantity and quality
|
|
|
|
BASE
|
|
Show details
|
|
|
| 15 |
Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
|
|
|
|
BASE
|
|
Show details
|
|
|
| 16 |
Associations of HLA alleles with specific language impairment
|
|
|
|
BASE
|
|
Show details
|
|
|
| 17 |
Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
|
|
|
|
BASE
|
|
Show details
|
|
|
| 18 |
Associations of HLA alleles with specific language impairment
|
|
|
|
BASE
|
|
Show details
|
|
|
| 19 |
Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
|
|
|
|
BASE
|
|
Show details
|
|
|
| 20 |
Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort.
|
|
|
|
In: ISSN: 1018-4813 ; EISSN: 1476-5438 ; European Journal of Human Genetics ; https://hal.archives-ouvertes.fr/hal-00964958 ; European Journal of Human Genetics, Nature Publishing Group, 2013, epub ahead of print. ⟨10.1038/ejhg.2013.199⟩ (2013)
|
|
BASE
|
|
Show details
|
|
|
|
|
