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Dynamic relationships between phonological memory and reading:a five year longitudinal study from age 4 to 9
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To Name or Not to Name:Eye Movements and Semantic Processing in RAN and Reading
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Auditory frequency discrimination in developmental dyslexia: a meta-analysis
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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On the neural basis of word reading:A meta-analysis of fMRI evidence using activation likelihood estimation
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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Auditory frequency discrimination in developmental dyslexia: A meta‐analysis
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Pettigrew, Kerry A; Frinton, Emily; Nudel, Ron; T.M. Chan, May; Thompson, Paul A.; Hayiou-Thomas, Marianna Emma; Talcott, Joel B.; Stein, John; Monaco, Anthony P.; Hulme, Charles; Snowling, Margaret Jean; Newbury, Dianne F; Paracchini, Silvia. - 2016
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Abstract:
Background: Specific Language Impairment (SLI) is a common neurodevelopmental disorder, observed in 5-10% of children. Family and twin studies suggest a strong genetic component, but relatively few candidate genes have been reported to date. A recent genome-wide association study (GWAS) described the first statistically significant association specifically for a SLI cohort between a missense variant (rs4280164) in the NOP9 gene and language-related phenotypes under a parent-of-origin model. Replications of these findings are particularly challenging because the availability of parental DNA is required. Methods: We used two independent family-based cohorts characterised with reading- and language-related traits: a longitudinal cohort (n = 106 informative families) including children with language and reading difficulties and a nuclear family cohort (n = 264 families) selected for dyslexia. Results: We observed association with language-related measures when modelling for parent-of-origin effects at the NOP9 locus in both cohorts: minimum P = 0.001 for phonological awareness with a paternal effect in the first cohort and minimum P = 0.0004 for irregular word reading with a maternal effect in the second cohort. Allelic and parental trends were not consistent when compared to the original study. Conclusions: A parent-of-origin effect at this locus was detected in both cohorts, albeit with different trends. These findings contribute in interpreting the original GWAS report and support further investigations of the NOP9 locus and its role in language-related traits. A systematic evaluation of parent-of-origin effects in genetic association studies has the potential to reveal novel mechanisms underlying complex traits.
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URL: https://eprints.whiterose.ac.uk/100713/ https://doi.org/10.1186/s11689-016-9157-6 https://eprints.whiterose.ac.uk/100713/1/Pettigrew_et_al._2016_JND.docx
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Genome-wide screening for DNA variants associated with reading and language traits
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Deconstructing phonological tasks:the contribution of stimulus and response type to the prediction of early decoding skills
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Increased prevalence of sex chromosome aneuploidies in specific language impairment and dyslexia.
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Increased prevalence of sex chromosome aneuploidies in specific language impairment and dyslexia
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort.
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In: ISSN: 1018-4813 ; EISSN: 1476-5438 ; European Journal of Human Genetics ; https://hal.archives-ouvertes.fr/hal-00964958 ; European Journal of Human Genetics, Nature Publishing Group, 2013, epub ahead of print. ⟨10.1038/ejhg.2013.199⟩ (2013)
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