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Lesion site and therapy time predict responses to a therapy for anomia after stroke: a prognostic model development study
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Abstract:
Stroke is a leading cause of disability, and language impairments (aphasia) after stroke are both common and particularly feared. Most stroke survivors with aphasia exhibit anomia (difficulties with naming common objects), but while many therapeutic interventions for anomia have been proposed, treatment effects are typically much larger in some patients than others. Here, we asked whether that variation might be more systematic, and even predictable, than previously thought. 18 patients, each at least 6 months after left hemisphere stroke, engaged in a computerised treatment for their anomia over a 6-week period. Using only: (a) the patients' initial accuracy when naming (to-be) trained items; (b) the hours of therapy that they devoted to the therapy; and (c) whole-brain lesion location data, derived from structural MRI; we developed Partial Least Squares regression models to predict the patients' improvements on treated items, and tested them in cross-validation. Somewhat surprisingly, the best model included only lesion location data and the hours of therapy undertaken. In cross-validation, this model significantly out-performed the null model, in which the prediction for each patient was simply the mean treatment effect of the group. This model also made promisingly accurate predictions in absolute terms: the correlation between empirical and predicted treatment response was 0.62 (95% CI 0.27, 0.95). Our results indicate that individuals' variation in response to anomia treatment are, at least somewhat, systematic and predictable, from the interaction between where and how much lesion damage they have suffered, and the time they devoted to the therapy.
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Keyword:
P Philology. Linguistics; RC Internal medicine
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URL: https://openaccess.city.ac.uk/id/eprint/26830/ https://doi.org/10.1038/s41598-021-97916-x https://openaccess.city.ac.uk/id/eprint/26830/1/Scientific_Reports_post_stroke.pdf
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Lesion-site-dependent responses to therapy after aphasic stroke
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Auditory training changes temporal lobe connectivity in ‘Wernicke’s aphasia’: a randomised trial
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Comparing language outcomes in monolingual and bilingual stroke patients.
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In: Brain , 138 (Pt 4) 1070 - 1083. (2015) (2015)
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An area essential for linking word meanings to word forms: evidence from primary progressive aphasia.
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In: Brain Lang , 127 (2) 167 - 176. (2013) (2013)
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Priming Naming
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In: In: 51ST ACADEMY OF APHASIA PROCEEDINGS. (pp. 74 - 75). (2013) (2013)
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Neuroimaging in aphasia treatment research: Consensus and practical guidelines for data analysis (vol 73, pg 215, 2013)
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In: NEUROIMAGE , 81 507 - 507. (2013) (2013)
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An Area Essential for Linking Word Meanings to Word Forms: Evidence from Primary Progressive Aphasia
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Structural correlates for lexical efficiency and number of languages in non-native speakers of English
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Speech Facilitation by Left Inferior Frontal Cortex Stimulation
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Parallel recovery in a trilingual speaker: the use of the Bilingual Aphasia Test as a diagnostic complement to the Comprehensive Aphasia Test
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Speech Facilitation by Left Inferior Frontal Cortex Stimulation
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In: CURR BIOL , 21 (16) 1403 - 1407. (2011) (2011)
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Patterns of breakdown in spelling in primary progressive aphasia.
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In: Cortex , 47 (3) 342 - 352. (2011) (2011)
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Parallel recovery in a trilingual speaker: the use of the Bilingual Aphasia Test as a diagnostic complement to the Comprehensive Aphasia Test
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In: CLIN LINGUIST PHONET , 25 (6-7) 499 - 512. (2011) (2011)
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Parallel recovery in a trilingual speaker: the use of the Bilingual Aphasia Test as a diagnostic complement to the Comprehensive Aphasia Test
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In: Clinical Linguistics and Phonetics 1 - 14. (2011) (2011)
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Parallel recovery in a trilingual speaker: The use of the bilingual aphasia test as a diagnostic complement to the comprehensive aphasia test
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In: Clinical Linguistics and Phonetics , 25 (6-7) 499 - 512. (2011) (2011)
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