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Cortical microstructure in primary progressive aphasia: a multicenter study.
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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Diminished preparatory physiological responses in frontotemporal lobar degeneration syndromes
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In: Brain Commun (2022)
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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring
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In: Alzheimers Dement (Amst) (2021)
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Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET
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In: Neurology (2021)
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Hearing loss prevalence and years lived with disability, 1990–2019 : findings from the Global Burden of Disease Study 2019
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Comparing two facets of emotion perception across multiple neurodegenerative diseases.
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In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020)
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Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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| 11 |
Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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| 13 |
Comparing two facets of emotion perception across multiple neurodegenerative diseases.
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In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020)
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| 14 |
Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium
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In: Alzheimers Dement (2020)
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Longitudinal structural and metabolic changes in frontotemporal dementia
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Bejanin, Alexandre; Tammewar, Gautam; Marx, Gabe; Cobigo, Yann; Iaccarino, Leonardo; Kornak, John; Staffaroni, Adam M.; Dickerson, Bradford C.; Boeve, Bradley F.; Knopman, David S.; Gorno-Tempini, Marilu; Miller, Bruce L.; Jagust, William J.; Boxer, Adam L.; Rosen, Howard J.; Rabinovici, Gil D.
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In: Neurology (2020)
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Abstract:
OBJECTIVE: To compare the sensitivity of structural MRI and (18)F-fludeoxyglucose PET ((18)FDG-PET) to detect longitudinal changes in frontotemporal dementia (FTD). METHODS: Thirty patients with behavioral variant FTD (bvFTD), 7 with nonfluent/agrammatic variant primary progressive aphasia (nfvPPA), 16 with semantic variant primary progressive aphasia (svPPA), and 43 cognitively normal controls underwent 2–4 MRI and (18)FDG-PET scans (total scans/visit = 270) as part of the Frontotemporal Lobar Degeneration Neuroimaging Initiative study. Linear mixed-effects models were carried out voxel-wise and in regions of interest to identify areas showing decreased volume or metabolism over time in patients as compared to controls. RESULTS: At baseline, patients with bvFTD showed bilateral temporal, dorsolateral, and medial prefrontal atrophy/hypometabolism that extended with time into adjacent structures and parietal lobe. In nfvPPA, baseline atrophy/hypometabolism in supplementary motor cortex extended with time into left greater than right precentral, dorsolateral, and dorsomedial prefrontal cortex. In svPPA, baseline atrophy/hypometabolism encompassed the anterior temporal and medial prefrontal cortex and longitudinal changes were found in temporal, orbitofrontal, and lateral parietal cortex. Across syndromes, there was substantial overlap in the brain regions showing volume and metabolism loss. Even though the pattern of metabolic decline was more extensive, metabolic changes were also more variable and sample size estimates were similar or higher for (18)FDG-PET compared to MRI. CONCLUSION: Our findings demonstrated the sensitivity of (18)FDG-PET and structural MRI for tracking disease progression in FTD. Both modalities showed highly overlapping patterns of longitudinal change and comparable sample size estimates to detect longitudinal changes in future clinical trials.
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Keyword:
Article
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URL: https://doi.org/10.1212/WNL.0000000000009760
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455324/
http://www.ncbi.nlm.nih.gov/pubmed/32591470
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Comparing two facets of emotion perception across multiple neurodegenerative diseases
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In: Soc Cogn Affect Neurosci (2020)
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Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages
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In: Front Neurol (2020)
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Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer’s disease
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Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
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Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.
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In: Lee, Suzee E; Sias, Ana C; Kosik, Eena L; Flagan, Taru M; Deng, Jersey; Chu, Stephanie A; et al.(2019). Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers. NeuroImage. Clinical, 22, 101751. doi:10.1016/j.nicl.2019.101751. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6vv8g8qt (2019)
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