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Estranged students in UK higher education: insights from two qualitative research studies
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| 2 |
VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
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HERC Ubiquitin Ligases in Cancer
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Abstract:
© 2020 by the authors. ; HERC proteins are ubiquitin E3 ligases of the HECT family. The HERC subfamily is composed of six members classified by size into large (HERC1 and HERC2) and small (HERC3–HERC6). HERC family ubiquitin ligases regulate important cellular processes, such as neurodevelopment, DNA damage response, cell proliferation, cell migration, and immune responses. Accumulating evidence also shows that this family plays critical roles in cancer. In this review, we provide an integrated view of the role of these ligases in cancer, highlighting their bivalent functions as either oncogenes or tumor suppressors, depending on the tumor type. We include a discussion of both the molecular mechanisms involved and the potential therapeutic strategies. ; J.L.R. is supported by the Spanish Ministry of Science and Innovation (BFU2016-80295-R, SAF2017-90900-REDT, and UBIRed). X.R.B. is supported by grants from the Castilla-León Government (CSI252P18, CLC-2017-01), the Spanish Ministry of Science and Innovation (SAF2015-64556-R, RTI2018-096481-B-100) and the Spanish Association against Cancer (GC16173472GARC). X.R.B.’s institution is supported by the Programa de Apoyo a Planes Estratégicos de Investigación de Estructuras de Investigación de Excelencia of the Castilla-León autonomous government (CLC-2017-01). Both Spanish and Castilla-León government-associated funding is partially supported by the European Regional Development Fund. J.S.-G. and A.M.-M. received FPU Fellowships (FPU17/02413 and FPU18/06325, respectively) from the Spanish Ministry of Science, Innovation and Universities.
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Keyword:
E3; ERK; Genome stability; HECT; MAPK; Oncogene; p38; p53; RAF; Tumor suppressor
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URL: https://doi.org/10.3390/cancers12061653
http://hdl.handle.net/10261/230761
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ASSET : a dataset for tuning and evaluation of sentence simplification models with multiple rewriting transformations
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| 5 |
Demographic Effects on Longitudinal Semantic Processing, Working Memory, and Cognitive Speed
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In: J Gerontol B Psychol Sci Soc Sci (2020)
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| 6 |
Factors Associated with Participation in the Chronic Disease Self-Management Program: Findings from the SUCCEED Trial
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In: Stroke (2020)
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| 9 |
The role of executive functions in object- and action-naming among older adults
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In: Exp Aging Res (2019)
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Breathe Easy, Speak Easy: Pulmonary Function and Language Performance in Aging
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Learning wellness in a new language : exploring views of ESL teachers about refugee mental health
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| 18 |
Structure, syntax and “small-world” organization in the complex songs of California Thrashers ( Toxostoma redivivum ) ...
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| 19 |
Structure, syntax and “small-world” organization in the complex songs of California Thrashers ( Toxostoma redivivum ) ...
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