1 |
Lesions that do or do not impair digit span: a study of 816 stroke survivors
|
|
|
|
In: Brain Commun (2021)
|
|
BASE
|
|
Show details
|
|
2 |
Damage to Broca’s area does not contribute to long-term speech production outcome after stroke
|
|
Gajardo-Vidal, Andrea; Lorca-Puls, Diego L; team, PLORAS; Warner, Holly; Pshdary, Bawan; Crinion, Jennifer T; Leff, Alexander P; Hope, Thomas M H; Geva, Sharon; Seghier, Mohamed L; Green, David W; Bowman, Howard; Price, Cathy J
|
|
In: Brain (2021)
|
|
Abstract:
Broca’s area in the posterior half of the left inferior frontal gyrus has long been thought to be critical for speech production. The current view is that long-term speech production outcome in patients with Broca’s area damage is best explained by the combination of damage to Broca’s area and neighbouring regions including the underlying white matter, which was also damaged in Paul Broca’s two historic cases. Here, we dissociate the effect of damage to Broca’s area from the effect of damage to surrounding areas by studying long-term speech production outcome in 134 stroke survivors with relatively circumscribed left frontal lobe lesions that spared posterior speech production areas in lateral inferior parietal and superior temporal association cortices. Collectively, these patients had varying degrees of damage to one or more of nine atlas-based grey or white matter regions: Brodmann areas 44 and 45 (together known as Broca’s area), ventral premotor cortex, primary motor cortex, insula, putamen, the anterior segment of the arcuate fasciculus, uncinate fasciculus and frontal aslant tract. Spoken picture description scores from the Comprehensive Aphasia Test were used as the outcome measure. Multiple regression analyses allowed us to tease apart the contribution of other variables influencing speech production abilities such as total lesion volume and time post-stroke. We found that, in our sample of patients with left frontal damage, long-term speech production impairments (lasting beyond 3 months post-stroke) were solely predicted by the degree of damage to white matter, directly above the insula, in the vicinity of the anterior part of the arcuate fasciculus, with no contribution from the degree of damage to Broca’s area (as confirmed with Bayesian statistics). The effect of white matter damage cannot be explained by a disconnection of Broca’s area, because speech production scores were worse after damage to the anterior arcuate fasciculus with relative sparing of Broca’s area than after damage to Broca’s area with relative sparing of the anterior arcuate fasciculus. Our findings provide evidence for three novel conclusions: (i) Broca’s area damage does not contribute to long-term speech production outcome after left frontal lobe strokes; (ii) persistent speech production impairments after damage to the anterior arcuate fasciculus cannot be explained by a disconnection of Broca’s area; and (iii) the prior association between persistent speech production impairments and Broca’s area damage can be explained by co-occurring white matter damage, above the insula, in the vicinity of the anterior part of the arcuate fasciculus.
|
|
Keyword:
Original Articles
|
|
URL: https://doi.org/10.1093/brain/awaa460 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041045/ http://www.ncbi.nlm.nih.gov/pubmed/33517378
|
|
BASE
|
|
Hide details
|
|
3 |
A Data-Based Approach for Selecting Pre- and Intra-Operative Language Mapping Tasks
|
|
|
|
In: Front Neurosci (2021)
|
|
BASE
|
|
Show details
|
|
4 |
Right hemisphere structural adaptation and changing language skills years after left hemisphere stroke
|
|
|
|
BASE
|
|
Show details
|
|
5 |
Language Control and Lexical Competition in Bilinguals: An Event-Related fMRI Study
|
|
|
|
BASE
|
|
Show details
|
|
6 |
Dissociating the semantic function of two neighbouring subregions in the left lateral anterior temporal lobe
|
|
|
|
BASE
|
|
Show details
|
|
7 |
A Trade-Off between Somatosensory and Auditory Related Brain Activity during Object Naming But Not Reading
|
|
|
|
BASE
|
|
Show details
|
|
8 |
Comparing language outcomes in monolingual and bilingual stroke patients
|
|
|
|
BASE
|
|
Show details
|
|
9 |
Inter- and Intrahemispheric Connectivity Differences When Reading Japanese Kanji and Hiragana
|
|
|
|
BASE
|
|
Show details
|
|
10 |
Dissecting the functional anatomy of auditory word repetition
|
|
|
|
BASE
|
|
Show details
|
|
11 |
The Importance of Premotor Cortex for Supporting Speech Production after Left Capsular-Putaminal Damage
|
|
|
|
BASE
|
|
Show details
|
|
12 |
Sensory-to-motor integration during auditory repetition: a combined fMRI and lesion study
|
|
|
|
BASE
|
|
Show details
|
|
14 |
The Angular Gyrus: Multiple Functions and Multiple Subdivisions
|
|
|
|
BASE
|
|
Show details
|
|
15 |
Inter- and Intrahemispheric Connectivity Differences When Reading Japanese Kanji and Hiragana
|
|
|
|
BASE
|
|
Show details
|
|
16 |
Inter- and Intrahemispheric Connectivity Differences When Reading Japanese Kanji and Hiragana
|
|
|
|
BASE
|
|
Show details
|
|
17 |
Auditory–motor interactions for the production of native and non-native speech
|
|
|
|
BASE
|
|
Show details
|
|
19 |
Where, When and Why Brain Activation Differs for Bilinguals and Monolinguals during Picture Naming and Reading Aloud
|
|
|
|
BASE
|
|
Show details
|
|
20 |
Where, When and Why Brain Activation Differs for Bilinguals and Monolinguals during Picture Naming and Reading Aloud
|
|
|
|
BASE
|
|
Show details
|
|
|
|