| 1 |
Test of a motor theory of long-term auditory memory.
|
|
|
|
In: Proc Natl Acad Sci U S A , 109 (18) 7121 - 7125. (2012) (2012)
|
|
BASE
|
|
Show details
|
|
|
| 2 |
Role of cerebellum in fine speech control in childhood: Persistent dysarthria after surgical treatment for posterior fossa tumour
|
|
|
|
BASE
|
|
Show details
|
|
|
| 3 |
Role of cerebellum in fine speech control in childhood: Persistent dysarthria after surgical treatment for posterior fossa tumour
|
|
|
|
In: BRAIN LANG , 117 (2) 69 - 76. (2011) (2011)
|
|
BASE
|
|
Show details
|
|
|
| 4 |
Endophenotypes of FOXP2: Dysfunction within the human articulatory network
|
|
|
|
In: EUR J PAEDIATR NEURO , 15 (4) 283 - 288. (2011) (2011)
|
|
Abstract:
The identification of the first gene involved in a speech-language disorder was made possible through the study of a British multi-generational family (the "KE family") in whom half the members have an inherited speech-language disorder caused by a FOXP2 mutation. Neuroimaging investigations in the affected members of the KE family have revealed structural and functional abnormalities in a wide cortical-subcortical network. Functional imaging studies have confirmed dysfunction of this network by revealing abnormal activation in several areas including Broca's area and the putamen during language-related tasks, such as word repetition and generation. Repeating nonsense words is particularly challenging for the affected members of the family, as well as in other individuals suffering from idiopathic developmental specific language impairments; yet, thus far the neural correlates of the nonword repetition task have not been examined in individuals with developmental speech and language disorders. Here, four affected members of the KE family and four unrelated age-matched healthy participants repeated nonsense words aloud during functional MRI scanning. Relative to control participants, repetition in the affected members was severely impaired, and brain activation was significantly reduced in the premotor, supplementary and primary motor cortices, as well as in the cerebellum and basal ganglia. We suggest that nonword repetition is the optimal endophenotype for FOXP2 disruption in humans because this task recruits brain regions involved in the imitation and vocal learning of novel sequences of speech sounds. (C) 2011 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
|
|
Keyword:
Articulation; BRAIN; Developmental verbal dyspraxia; fMRI; FOXP2; GENE; INHERITED SPEECH; LANGUAGE DISORDER
|
|
URL: http://discovery.ucl.ac.uk/1319268/
|
|
BASE
|
|
Hide details
|
|
|
| 5 |
Speech and oral motor profile after childhood hemispherectomy
|
|
|
|
BASE
|
|
Show details
|
|
|
| 6 |
Speech and oral motor profile after childhood hemispherectomy
|
|
|
|
BASE
|
|
Show details
|
|
|
| 7 |
Is the hippocampus necessary for visual and verbal binding in working memory?
|
|
|
|
In: NEUROPSYCHOLOGIA , 48 (4) 1089 - 1095. (2010) (2010)
|
|
BASE
|
|
Show details
|
|
|
| 8 |
Speech and oral motor profile after childhood hemispherectomy
|
|
|
|
In: BRAIN LANG , 114 (2) 126 - 134. (2010) (2010)
|
|
BASE
|
|
Show details
|
|
|
| 9 |
Speaking with a single cerebral hemisphere: fMRI language organization after hemispherectomy in childhood
|
|
|
|
In: BRAIN LANG , 106 (3) 195 - 203. (2008) (2008)
|
|
BASE
|
|
Show details
|
|
|
| 10 |
Cortical abnormalities and language function in young patients with basal ganglia stroke
|
|
|
|
In: NEUROIMAGE , 36 (2) 431 - 440. (2007) (2007)
|
|
BASE
|
|
Show details
|
|
|
| 11 |
Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2005)
|
|
BASE
|
|
Show details
|
|
|
| 12 |
Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits
|
|
|
|
In: American Journal of Human Genetics , 76 (6) pp. 1074-1080. (2005) (2005)
|
|
BASE
|
|
Show details
|
|
|
| 13 |
Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits
|
|
|
|
In: AM J HUM GENET , 76 (6) 1074 - 1080. (2005) (2005)
|
|
BASE
|
|
Show details
|
|
|
| 14 |
Identification of FOXP2 Truncation as a novel cause of developmental speech and language deficits
|
|
|
|
In: American Journal of Human Genetics , 76 (6) pp.1074 - 1080. (2005) (2005)
|
|
BASE
|
|
Show details
|
|
|
| 15 |
Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI study
|
|
|
|
In: BRAIN , 127 1229 - 1236. (2004) (2004)
|
|
BASE
|
|
Show details
|
|
|
| 16 |
Cortical lateralization during verb generation: a combined ERP and fMRI study
|
|
|
|
In: NEUROIMAGE , 22 (2) 665 - 675. (2004) (2004)
|
|
BASE
|
|
Show details
|
|
|
| 17 |
Functional MRI abnormalities during covert speech associated with FOXP2 gene mutation
|
|
|
|
In: Nature Neuroscience , 6 (11 ) pp.1230 - 1237 . (2003) (2003)
|
|
BASE
|
|
Show details
|
|
|
| 18 |
Language fMRI abnormalities associated with FOXP2 gene mutation
|
|
|
|
In: NAT NEUROSCI , 6 (11) 1230 - 1237. (2003) (2003)
|
|
BASE
|
|
Show details
|
|
|
| 19 |
Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia
|
|
|
|
BASE
|
|
Show details
|
|
|
| 20 |
Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2002)
|
|
BASE
|
|
Show details
|
|
|
|
|
