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Test of a motor theory of long-term auditory memory.
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In: Proc Natl Acad Sci U S A , 109 (18) 7121 - 7125. (2012) (2012)
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Role of cerebellum in fine speech control in childhood: Persistent dysarthria after surgical treatment for posterior fossa tumour
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Role of cerebellum in fine speech control in childhood: Persistent dysarthria after surgical treatment for posterior fossa tumour
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In: BRAIN LANG , 117 (2) 69 - 76. (2011) (2011)
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Endophenotypes of FOXP2: Dysfunction within the human articulatory network
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In: EUR J PAEDIATR NEURO , 15 (4) 283 - 288. (2011) (2011)
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Speech and oral motor profile after childhood hemispherectomy
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Speech and oral motor profile after childhood hemispherectomy
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Is the hippocampus necessary for visual and verbal binding in working memory?
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In: NEUROPSYCHOLOGIA , 48 (4) 1089 - 1095. (2010) (2010)
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Speech and oral motor profile after childhood hemispherectomy
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In: BRAIN LANG , 114 (2) 126 - 134. (2010) (2010)
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Speaking with a single cerebral hemisphere: fMRI language organization after hemispherectomy in childhood
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In: BRAIN LANG , 106 (3) 195 - 203. (2008) (2008)
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Cortical abnormalities and language function in young patients with basal ganglia stroke
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In: NEUROIMAGE , 36 (2) 431 - 440. (2007) (2007)
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Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2005)
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Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits
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In: American Journal of Human Genetics , 76 (6) pp. 1074-1080. (2005) (2005)
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Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits
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In: AM J HUM GENET , 76 (6) 1074 - 1080. (2005) (2005)
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Identification of FOXP2 Truncation as a novel cause of developmental speech and language deficits
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In: American Journal of Human Genetics , 76 (6) pp.1074 - 1080. (2005) (2005)
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Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI study
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In: BRAIN , 127 1229 - 1236. (2004) (2004)
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Cortical lateralization during verb generation: a combined ERP and fMRI study
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In: NEUROIMAGE , 22 (2) 665 - 675. (2004) (2004)
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Functional MRI abnormalities during covert speech associated with FOXP2 gene mutation
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In: Nature Neuroscience , 6 (11 ) pp.1230 - 1237 . (2003) (2003)
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Language fMRI abnormalities associated with FOXP2 gene mutation
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In: NAT NEUROSCI , 6 (11) 1230 - 1237. (2003) (2003)
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Abstract:
Half the members of the KE family suffer from a speech and language disorder caused by a mutation in the FOXP2 gene. We examined functional brain abnormalities associated with this mutation using two fMRI language experiments, one involving covert (silent) verb generation and the other overt (spoken) verb generation and word repetition. The unaffected family members showed a typical left-dominant distribution of activation involving Broca's area in the generation tasks and a more bilateral distribution in the repetition task, whereas the affected members showed a more posterior and more extensively bilateral pattern of activation in all tasks. Consistent with previously reported bilateral morphological abnormalities, the affected members showed significant underactivation relative to the unaffected members in Broca's area and its right homolog, as well as in other cortical language-related regions and in the putamen. Our findings suggest that the FOXP2 gene is critically involved in the development of the neural systems that mediate speech and language.
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Keyword:
BASAL GANGLIA; BRAIN ABNORMALITIES; COGNITIVE DEFICITS; DISORDER; FRONTAL LESIONS; INHERITED SPEECH; MRI-ANALYSIS; PREFRONTAL CORTEX; VERB GENERATION; WORD GENERATION
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URL: http://discovery.ucl.ac.uk/7979/
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Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia
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Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2002)
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