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Lessons Learned from the Usability Evaluation of a Simulated Patient Dialogue System
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In: ISSN: 0148-5598 ; EISSN: 1573-689X ; Journal of Medical Systems ; https://hal.archives-ouvertes.fr/hal-03452553 ; Journal of Medical Systems, Springer Verlag (Germany), 2021, 45 (7), ⟨10.1007/s10916-021-01737-4⟩ (2021)
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Differential Evaluation: a Qualitative Analysis of Natural Language Processing System Behavior Based Upon Data Resistance to Processing
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In: Proceedings of the 2nd Workshop on Evaluation and Comparison of NLP Systems ; EVAL4NLP, 2nd Workshop on "Evaluation & Comparison of NLP Systems", EMNLP 2021 ; https://hal.archives-ouvertes.fr/hal-03432331 ; EVAL4NLP, 2nd Workshop on "Evaluation & Comparison of NLP Systems", EMNLP 2021, Nov 2021, Punta Cana, Dominican Republic (2021)
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Overview of the Fourth BUCC Shared Task: Bilingual Dictionary Induction from Comparable Corpora
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In: 13th Workshop on Building and Using Comparable Corpora (BUCC) ; https://hal.archives-ouvertes.fr/hal-03100822 ; 13th Workshop on Building and Using Comparable Corpora (BUCC), May 2020, Marseille, France. pp.6-13 (2020)
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Designing a virtual patient dialogue system based on terminology-rich resources: Challenges and evaluation
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Automatic Removal of Identifying Information in Official EU Languages for Public Administrations: The MAPA Project
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In: Legal Knowledge and Information Systems ; Frontiers in Artificial Intelligence and Applications ; International Conference on Legal Knowledge and Information Systems ; https://hal.archives-ouvertes.fr/hal-03058311 ; International Conference on Legal Knowledge and Information Systems, Dec 2020, Brno, Prague, Czech Republic. pp.223-226, ⟨10.3233/FAIA200869⟩ ; http://ebooks.iospress.nl/volume/legal-knowledge-and-information-systems-jurix-2020-the-thirty-third-annual-conference-brno-czech-republic-december-911-2020 (2020)
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The Multilingual Anonymisation Toolkit for Public Administrations (MAPA) Project
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In: Annual Conference of the European Association for Machine Translation ; https://hal.archives-ouvertes.fr/hal-03103205 ; Annual Conference of the European Association for Machine Translation, Nov 2020, Lisbon, Portugal. pp.471-472 (2020)
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TL-Explorer: A Digital Humanities Tool for Mapping and Analyzing Translated Literature
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In: Proceedings of the The 4th Joint SIGHUM Workshop on Computational Linguistics for Cultural Heritage, Social Sciences, Humanities and Literature ; https://hal.archives-ouvertes.fr/hal-03090881 ; Proceedings of the The 4th Joint SIGHUM Workshop on Computational Linguistics for Cultural Heritage, Social Sciences, Humanities and Literature, Dec 2020, Barcelona, Spain ; https://www.aclweb.org/anthology/2020.latechclfl-1.20/ (2020)
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CharacterBERT: Reconciling ELMo and BERT for Word-Level Open-Vocabulary Representations From Characters
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In: International Conference on Computational Linguistics ; https://hal.archives-ouvertes.fr/hal-03100665 ; International Conference on Computational Linguistics, Dec 2020, Barcelona (on line), Spain. pp.6903-6915 ; https://coling2020.org/ (2020)
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French Levothyrox® Crisis: Retrospective Analysis of Social Media
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In: International Society of Pharmacovigilance ; https://hal.archives-ouvertes.fr/hal-02411632 ; International Society of Pharmacovigilance, Springer International Publishing, Oct 2019, Bogota, Colombia (2019)
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Abstract:
International audience ; Introduction and Background: Since June 2011, the European legislation allows patients and patients' organizations to report adverse drug reactions (ADRs). In France, in 2017, more than 32,000 ADRs were reported by patients representing 42% of all ADRs collected yearly and an unexpected increase in patient reports (5.8% in 2016). Most of these cases involved the new Levothyrox® formulation (available since March 2017), leading to the "French Levothyrox® Crisis" [1]. To evaluate whether such crises can be predicted by analyzing social media data, the PHARES multidisciplinary consortium carried out the Levothyrox® case study that is described in this abstract. The PHARES project was funded from 2017 to 2019 by the French National Agency for the Safety of Medicines and Health Products (ANSM [2]) with the objective to implement a computerized tool for social media mining. Objectives: Quantitative and qualitative analysis of Levothyrox® mentions in a French web site dedicated to thyroid pathology to investigate whether social media may be useful to predict ADR-related crises. Methods: All posts published in the forums of the "Vivre sans thyroïde" website were collected and annotated automatically using machine learning and natural language processing methods to identify mentions of drugs and potential Adverse Events (AE) [3, 4]. Only posts containing at least one mention of Levothyrox® or levothyroxine were considered as our analysis collection. From this data sample, we first counted the number of posts per each verbatim detected by the annotation algorithm to identify those AEs most mentioned with Levothyrox®. The 100 most mentioned verbatims were then manually reviewed and classified into categories by a pharmacovigilance expert (cf. Table 1). This manual step generated an association list (verbatim -> Category) that we used as a reference to generate the following statistics over the whole collection: the number of posts per category, the number of posts per AE in each category, and the evolution over time of the number of posts per AE and per category and a time-series analysis using change-point analysis method (CPA) [5].Results: As for July 2018, the studied website contained over 900 thousand posts published since 2001. The evolution of the number of AE mentions associated to Levothyrox® from June 2005 to July 2018 shows no particular rise was present before the first declaration to the pharmacovigilance network. The qualitative analysis of the categories selected for this study resulted in: 25% of General AE, 25% of Levothyrox® indication, 18% of neurological and psychiatric effects, 7% of seriousness description ("emergency", "consultation", "crisis") and 5% of cardiovascular effects. The main AEs associated to general effects are "tiredness", "weight gain" and "pain". The CPA method shows a change point one month before the beginning of the crisis.Conclusion and perspectives: To our knowledge, this study is the first retrospective analysis of social media data following a drug health crisis. It concerns a new formulation of a drug used by more than 3 million people in France, leading to thousands of patients' complaints about ADRs. Most of the collected AEs were expected, some of them may be difficult to classify and a human evaluation is still required. The detected change point corresponds to a low variation and further investigations need to be performed.
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Keyword:
[INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL]; [INFO]Computer Science [cs]; ANSM; Information Extraction; Levothyrox; Natural Language Processing; Pharmacovigilance
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URL: https://hal.archives-ouvertes.fr/hal-02411632
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Demonette2 \textendash A large scale derivational database for French: first results ; Demonette2 - Une base de données dérivationnelle du français à grande échelle : premiers résultats
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In: Conférence sur le Traitement Automatique des Langues Naturelles (TALN) - PFIA ; https://hal.archives-ouvertes.fr/hal-02567772 ; Conférence sur le Traitement Automatique des Langues Naturelles (TALN) - PFIA, Jul 2019, Toulouse, France. pp.233-244 (2019)
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Apprentissage de plongements de mots dynamiques avec régularisation de la dérive
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In: Actes de la Conférence sur le Traitement Automatique des Langues Naturelles (TALN) PFIA 2019. Volume I : Articles longs ; 26e Conférence sur le Traitement Automatique des Langues Naturelles ; https://hal.archives-ouvertes.fr/hal-02566346 ; 26e Conférence sur le Traitement Automatique des Langues Naturelles, 2019, Toulouse, France. pp.13-26 (2019)
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PolylexFLE : une base de données d'expressions polylexicales pour le FLE
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In: Actes de la Conférence sur le Traitement Automatique des Langues Naturelles (TALN) PFIA 2019. Volume I : Articles longs ; 26e Conférence sur le Traitement Automatique des Langues Naturelles ; https://hal.archives-ouvertes.fr/hal-02566348 ; 26e Conférence sur le Traitement Automatique des Langues Naturelles, 2019, Toulouse, France. pp.143-156 (2019)
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Cross-Lingual Contextual Word Embeddings Mapping with Multi-Sense Words in Mind
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In: https://hal.archives-ouvertes.fr/hal-03100840 ; 2019 (2019)
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Exploration de l'apprentissage par transfert pour l'analyse de textes des réseaux sociaux
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In: 26e Conférence sur le Traitement Automatique des Langues Naturelles ; https://hal.archives-ouvertes.fr/hal-02567773 ; 26e Conférence sur le Traitement Automatique des Langues Naturelles, 2019, Toulouse, France. pp.293-302 (2019)
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A Sustainable and Open Access Knowledge Organization Model to Preserve Cultural Heritage and Language Diversity
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In: ISSN: 2078-2489 ; Information ; https://hal.archives-ouvertes.fr/hal-02565134 ; Information, MDPI, 2019, 10 (10), pp.303. ⟨10.3390/info10100303⟩ (2019)
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Tooling up a less-resourced language with NLP : the example of Corsican and BDLC ; Outiller une langue peu dotée grâce au TALN : l’exemple du corse et BDLC
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In: 26e Conférence sur le Traitement Automatique des Langues Naturelles ; https://hal.archives-ouvertes.fr/hal-02567779 ; 26e Conférence sur le Traitement Automatique des Langues Naturelles, 2019, Toulouse, France. pp.371-380 (2019)
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Embedding Strategies for Specialized Domains: Application to Clinical Entity Recognition
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In: Proceedings of the 57th Annual Meeting of the Association for Computational Linguistics: Student Research Workshop ; https://hal.archives-ouvertes.fr/hal-02860947 ; Proceedings of the 57th Annual Meeting of the Association for Computational Linguistics: Student Research Workshop, Jul 2019, Florence, France. pp.295-301, ⟨10.18653/v1/P19-2041⟩ (2019)
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Actes de la Conférence sur le Traitement Automatique des Langues Naturelles (TALN) - PFIA 2019
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In: https://hal.archives-ouvertes.fr/hal-02566345 ; Morin, Emmanuel and Rosset, Sophie and Zweigenbaum, Pierre. Jul 2019, Toulouse, France. ATALA, 2019 (2019)
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Designing a virtual patient dialogue system based on terminology-rich resources: challenges and evaluation
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In: ISSN: 1351-3249 ; EISSN: 1469-8110 ; Natural Language Engineering ; https://hal.archives-ouvertes.fr/hal-02358021 ; Natural Language Engineering, Cambridge University Press (CUP), 2019, pp.1-38 (2019)
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Tooling up a less-resourced language with NLP : the example of Corsican and BDLC ; Outiller une langue peu dotée grâce au TALN : l’exemple du corse et BDLC
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In: 26e Conférence sur le Traitement Automatique des Langues Naturelles ; https://hal.archives-ouvertes.fr/hal-02452276 ; 26e Conférence sur le Traitement Automatique des Langues Naturelles, 2019, Toulouse, France. pp.371-380 (2019)
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