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Crohn’s disease: is the cold chain hypothesis still hot?
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In: ISSN: 1873-9946 ; EISSN: 1876-4479 ; Journal of Crohn's and Colitis ; https://hal.inrae.fr/hal-03030942 ; Journal of Crohn's and Colitis, Elsevier - Oxford University Press, In press, ⟨10.1093/ecco-jcc/jjaa192⟩ (2020)
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Abstract:
Crohn’s disease (CD) is an inflammatory bowel disease of unknown etiology. During the last decades, significant technological advances led to development of -omic datasets allowing a detailed description of the disease. Unfortunately, these have not, to date, resolved the question of the etiology of CD. Thus, it may be necessary to (re)consider hypothesis-driven approaches to resolve the etiology of CD. According to the cold chain hypothesis, the development of industrial and domestic refrigeration has led to frequent exposure of human populations to bacteria capable of growing in the cold. These bacteria, at low levels of exposure, particularly those of the genus Yersinia, are believed to be capable of inducing exacerbated inflammation of the intestine in genetically predisposed subjects. We discuss the consistency of this working hypothesis in light of recent data from epidemiological, clinical, pathological, microbiological and molecular studies.
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Keyword:
[SDV.BBM]Life Sciences [q-bio]/Biochemistry; [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology; autophagy; Causality chain; cold; creeping fat; Crohn Disease; enteral nutrition; exclusion diet; food products; gut inflammation; macrophages; mesenteric lymph nodes; Molecular Biology; mucosal immune response; plague; refrigeration; Yersinia
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URL: https://doi.org/10.1093/ecco-jcc/jjaa192
https://hal.inrae.fr/hal-03030942/document
https://hal.inrae.fr/hal-03030942
https://hal.inrae.fr/hal-03030942/file/Hugot-CC-2020.pdf
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Sémantique des possibles argumentatifs et théorie de la proximisation : vers un modèle pragmatique hybride d’analyse critique du discours
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In: ISSN: 1253-9708 ; Scolia ; https://hal.univ-rennes2.fr/hal-02103701 ; Scolia, Université des sciences humaines Strasbourg, 2016, pp.157-172 ; https://journals.openedition.org/scolia/440#quotation (2016)
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| 5 |
Prédiscours, interdiscours et postdiscours : analyse critique de la circulation des possibles discursifs
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In: ISSN: 1285-4093 ; Revue de Sémantique et Pragmatique ; https://hal.univ-rennes2.fr/hal-02103280 ; Revue de Sémantique et Pragmatique, Presses de l'Université d'Orléans, 2016, 39 (39), pp.95-110. ⟨10.4000/rsp.422⟩ (2016)
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| 6 |
АРХИТЕКТУРА СОБЫТИЙНОГО КОНЦЕПТА (НА ПРИМЕРЕ ВЕРБАЛИЗОВАННОЙ СИТУАЦИИ ПОЗНАНИЯ ЗАПАХА)
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| 7 |
Programmable volatile/non-volatile memory cell
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In: https://hal-lirmm.ccsd.cnrs.fr/lirmm-01688122 ; United States, Patent n° : US20140050012 A1. 2014 (2014)
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| 9 |
Enabling Efficient Intelligence Analysis in Degraded Environments
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In: DTIC (2013)
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| 10 |
Distributed Estimation in Sensor Networks with Imperfect Model Information: An Adaptive Learning-Based Approach
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In: DTIC (2012)
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| 11 |
Uncovering and Managing the Impact of Methodological Choices for the Computational Construction of Socio-Technical Networks from Texts
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In: DTIC (2012)
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| 12 |
Visualization of a Text Network Structure Using X3D
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In: DTIC (2008)
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| 13 |
An MCTAG with Tuples for Coherent Constructions in German
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In: http://www.dei.unipd.it/~fgrammar/fg07/fg07preproc/0010/paper_12.pdf (2007)
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| 14 |
The Problem of Ontology Alignment on the Web: A First Report
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In: DTIC (2006)
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| 16 |
Initial Kernel Timing Using a Simple PIM Performance Model
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In: DTIC AND NTIS (2005)
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| 18 |
Hypertext and Multimedia for Functional Enhancement of USARIEM Medical Handbooks and Biomedical Simulation Software.
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In: DTIC AND NTIS (1994)
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| 19 |
A Flexible, Parallel Model of Natural Language Generation
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In: DTIC (1991)
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A Formal Theory of C3 and Data Fusion
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In: DTIC AND NTIS (1991)
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