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DYT-TUBB4A (DYT4 Dystonia): New Clinical and Genetic Observations.
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In: Neurology, vol. 96, no. 14, pp. e1887-e1897 (2021)
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Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
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In: Molecular psychiatry, vol 25, iss 10 (2020)
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Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
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In: Molecular psychiatry, vol 25, iss 10 (2020)
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Spatially explicit analysis reveals complex human genetic gradients in the Iberian Peninsula
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Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis.
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In: Human molecular genetics, vol 27, iss 24 (2018)
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Enrichment of genetic markers of recent human evolution in educational and cognitive traits.
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Srinivasan, Saurabh; Bettella, Francesco; Frei, Oleksandr; Hill, W David; Wang, Yunpeng; Witoelar, Aree; Schork, Andrew J; Thompson, Wesley K; Davies, Gail; Desikan, Rahul S; Deary, Ian J; Melle, Ingrid; Ueland, Torill; Dale, Anders M; Djurovic, Srdjan; Smeland, Olav B; Andreassen, Ole A
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In: Scientific reports, vol 8, iss 1 (2018)
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Abstract:
Higher cognitive functions are regarded as one of the main distinctive traits of humans. Evidence for the cognitive evolution of human beings is mainly based on fossil records of an expanding cranium and an increasing complexity of material culture artefacts. However, the molecular genetic factors involved in the evolution are still relatively unexplored. Here, we investigated whether genomic regions that underwent positive selection in humans after divergence from Neanderthals are enriched for genetic association with phenotypes related to cognitive functions. We used genome wide association data from a study of college completion (N = 111,114), one of educational attainment (N = 293,623) and two different studies of general cognitive ability (N = 269,867 and 53,949). We found nominally significant polygenic enrichment of associations with college completion (p = 0.025), educational attainment (p = 0.043) and general cognitive ability (p = 0.015 and 0.025, respectively), suggesting that variants influencing these phenotypes are more prevalent in evolutionarily salient regions. The enrichment remained significant after controlling for other known genetic enrichment factors, and for affiliation to genes highly expressed in the brain. These findings support the notion that phenotypes related to higher order cognitive skills typical of humans have a recent genetic component that originated after the separation of the human and Neanderthal lineages.
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Keyword:
Biochemistry and Cell Biology; Biological Evolution; Biotechnology; Brain; Clinical Research; Cognition; Educational Status; Female; Genetic Markers; Genetics; Genome; Genome-Wide Association Study; Human Genome; Humans; Intelligence; Male; Mental Health; Multifactorial Inheritance; Other Physical Sciences; Phenotype; Polymorphism; Single Nucleotide
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URL: https://escholarship.org/uc/item/1n9569p1
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Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.
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In: Nature genetics, vol 50, iss 7 (2018)
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Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).
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In: Twin research and human genetics : the official journal of the International Society for Twin Studies, vol 21, iss 5 (2018)
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Global genetic differentiation of complex traits shaped by natural selection in humans.
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In: Nature communications, vol. 9, no. 1, pp. 1865 (2018)
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GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.
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In: Molecular psychiatry, vol 22, iss 3 (2017)
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AD-LIBS: inferring ancestry across hybrid genomes using low-coverage sequence data.
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In: BMC bioinformatics, vol 18, iss 1 (2017)
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A Neolithic expansion, but strong genetic structure, in the independent history of New Guinea. ...
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An ancient selective sweep linked to reproductive life history evolution in sockeye salmon
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An ancient selective sweep linked to reproductive life history evolution in sockeye salmon
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A Neolithic expansion, but strong genetic structure, in the independent history of New Guinea
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Global Genomic Epidemiology of Salmonella enterica Serovar Typhimurium DT104.
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In: ISSN: 0099-2240 ; EISSN: 1098-5336 ; Applied and Environmental Microbiology ; https://hal-pasteur.archives-ouvertes.fr/pasteur-01421019 ; Applied and Environmental Microbiology, American Society for Microbiology, 2016, 82 (8), pp.2516-26. ⟨10.1128/AEM.03821-15⟩ (2016)
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Coevolution of genes and languages and high levels of population structure among the highland populations of Daghestan.
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In: Journal of human genetics, vol 61, iss 3 (2016)
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Fine-Scale Human Population Structure in Southern Africa Reflects Ecogeographic Boundaries.
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In: Genetics, vol 204, iss 1 (2016)
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| 19 |
Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.
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In: Brain imaging and behavior, vol 10, iss 1 (2016)
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Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.
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In: Brain imaging and behavior, vol 10, iss 1 (2016)
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