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Semantic Feature Extraction Using SBERT for Dementia Detection
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In: Brain Sciences; Volume 12; Issue 2; Pages: 270 (2022)
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Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
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Neural dynamics of semantic categorization in semantic variant of primary progressive aphasia.
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Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
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Yang, Winson FZ; Toller, Gianina; Shdo, Suzanne; Kotz, Sonja A; Brown, Jesse; Seeley, William W; Kramer, Joel H; Miller, Bruce L; Rankin, Katherine P. - : eScholarship, University of California, 2021
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Abstract:
ObjectiveStructural and task-based functional studies associate emotion reading with frontotemporal brain networks, though it remains unclear whether functional connectivity (FC) alone predicts emotion reading ability. The predominantly frontotemporal salience and semantic appraisal (SAN) networks are selectively impacted in neurodegenerative disease syndromes like behavioral-variant frontotemporal dementia (bvFTD) and semantic-variant primary progressive aphasia (svPPA). Accurate emotion identification diminishes in some of these patients, but studies investigating the source of this symptom in patients have predominantly examined structural rather than functional brain changes. Thus, we investigated the impact of altered connectivity on their emotion reading.MethodsOne-hundred-eighty-five participants (26 bvFTD, 21 svPPA, 24 non-fluent variant PPA, 24 progressive supranuclear palsy, 49 Alzheimer's disease, 41 neurologically healthy older controls) underwent task-free fMRI, and completed the Emotion Evaluation subtest of The Awareness of Social Inference Test (TASIT-EET), watching videos and selecting labels for actors' emotions.ResultsAs expected, patients averaged significantly worse on emotion reading, but with wide inter-individual variability. Across all groups, lower mean FC in the SAN, but not other ICNs, predicted worse TASIT-EET performance. Node-pair analysis revealed that emotion identification was predicted by FC between 1) right anterior temporal lobe (RaTL) and right anterior orbitofrontal (OFC), 2) RaTL and right posterior OFC, and 3) left basolateral amygdala and left posterior OFC.ConclusionEmotion reading test performance predicts FC in specific SAN regions mediating socioemotional semantics, personalized evaluations, and salience-driven attention, highlighting the value of emotion testing in clinical and research settings to index neural circuit dysfunction in patients with neurodegeneration and other neurologic disorders.
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Keyword:
2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aging; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Aphasia; Basic Behavioral and Social Science; Behavioral and Social Science; Brain; Brain Disorders; Clinical Research; Dementia; Emotion reading; Emotions; Frontotemporal Dementia; Frontotemporal Dementia (FTD); Functional connectivity; Humans; Magnetic Resonance Imaging; Neurodegeneration; Neurodegenerative; Neurodegenerative Diseases; Neurological; Neurosciences; Primary Progressive; Right anterior temporal lobe; Semantic appraisal network; Semantics
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URL: https://escholarship.org/uc/item/67m8f14f
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What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
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What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
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| 7 |
“Hard to Say, Hard to Understand, Hard to Live”: Possible Associations between Neurologic Language Impairments and Suicide Risk
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In: Brain Sciences; Volume 11; Issue 12; Pages: 1594 (2021)
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| 8 |
Semantic Variant Primary Progressive Aphasia: Practical Recommendations for Treatment from 20 Years of Behavioural Research
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In: Brain Sciences ; Volume 11 ; Issue 12 (2021)
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| 9 |
The Free Association Task: Proposal of a Clinical Tool for Detecting Differential Profiles of Semantic Impairment in Semantic Dementia and Alzheimer’s Disease
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In: Medicina ; Volume 57 ; Issue 11 (2021)
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| 10 |
Distinctive Oculomotor Behaviors in Alzheimer's Disease and Frontotemporal Dementia
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| 11 |
The White Matter Module-Hub Network of Semantics Revealed by Semantic Dementia
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In: ISSN: 0898-929X ; EISSN: 1530-8898 ; Journal of Cognitive Neuroscience ; https://hal.inria.fr/hal-02554966 ; Journal of Cognitive Neuroscience, Massachusetts Institute of Technology Press (MIT Press), 2020, pp.1-18. ⟨10.1162/jocn_a_01549⟩ (2020)
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| 12 |
When affect overlaps with concept: emotion recognition in semantic variant of primary progressive aphasia
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In: ISSN: 0006-8950 ; EISSN: 1460-2156 ; Brain - A Journal of Neurology ; https://www.hal.inserm.fr/inserm-02924278 ; Brain - A Journal of Neurology , Oxford University Press (OUP), In press, ⟨10.1093/brain/awaa313⟩ (2020)
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| 13 |
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
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| 14 |
Regional and hemispheric susceptibility of the temporal lobe to FTLD-TDP type C pathology.
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| 15 |
Towards Understanding the Relationship between Language and Memory in Discourse
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| 16 |
The - weak - role of memory in tool use : Evidence from neurodegenerative diseases
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In: ISSN: 0028-3932 ; EISSN: 1873-3514 ; Neuropsychologia ; https://hal.archives-ouvertes.fr/hal-02392362 ; Neuropsychologia, Elsevier, 2019, 129, pp.117-132. ⟨10.1016/j.neuropsychologia.2019.03.008⟩ (2019)
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial
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In: ISSN: 1745-6215 ; Trials ; https://hal.sorbonne-universite.fr/hal-02407657 ; Trials, BioMed Central, 2019, 20 (1), pp.632. ⟨10.1186/s13063-019-3613-z⟩ (2019)
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| 18 |
Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
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In: Toller, Gianina; Yang, Winson FZ; Brown, Jesse A; Ranasinghe, Kamalini G; Shdo, Suzanne M; Kramer, Joel H; et al.(2019). Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity. NeuroImage. Clinical, 22, 101729. doi:10.1016/j.nicl.2019.101729. UCSF: Retrieved from: http://www.escholarship.org/uc/item/9qm527cr (2019)
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| 19 |
Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
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Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
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