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1
The spectrum of language impairments in amyotrophic lateral sclerosis
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2
Alterations to dual stream connectivity predicts response to aphasia therapy following stroke
Abstract: Background: Predicting aphasia recovery is difficult due to a high variability in treatment response. Detailed measures of treatment response are compounded by a dearth of information that examine brain connections that contribute to clinical improvement. In this study we measure alterations to cortical connectivity pathways during a therapy paradigm to detect whether key brain connections that contribute to language recovery can be detected prior to therapy. Methods: We conducted a case–control trial with twenty-three adults including eight adults with chronic, post-stroke aphasia. Aphasia patients underwent 12 naming therapy sessions over 4 weeks, consisting of semantic and phonological treatment approaches. High-density electroencephalography (128 channel EEG) was measured prior to therapy and immediately following treatment in patients with aphasia. Analysis via a dynamic causal modelling (DCM) was used to assess which cortical connections significantly correlated with therapy response. Results: Altered cortical responses in aphasia patients measured bilaterally in a dual stream DCM connectivity model were predictive of treatment-induced improvement in naming. Pre-treatment DCM coupling (i.e., strength of cortical connections) significant correlated with naming improvement for items treated with semantic therapy, as indicated by increased connection strengths between left inferior parietal lobule (LIPL) and inferior frontal gyrus (LIFG, r = .63, pFDR = .016). In particular, the mediating role of contralateral regions significantly influences overall treatment improvement in the latter stages of stroke recovery. Conclusions: Our findings identify a potential means to stratify larger cohorts of patients in neurorehabilitation settings into distinct treatments that are tailored to their individual language deficit.
Keyword: 2805 Cognitive Neuroscience; 3205 Experimental and Cognitive Psychology; 3206 Neuropsychology and Physiological Psychology; Dynamic causal modelling; High-density EEG; Naming treatment; Post-stroke aphasia; Stroke recovery
URL: https://espace.library.uq.edu.au/view/UQ:4b08715/UQ4b08715_OA.pdf
https://espace.library.uq.edu.au/view/UQ:4b08715
https://espace.library.uq.edu.au/view/UQ:4b08715/thumbnail_UQ4b08715_OA_t.jpg
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3
Explaining short-term memory phenomena with an integrated episodic/semantic framework of long-term memory
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4
Neural correlates of emotion-attention interactions: from perception, learning, and memory to social cognition, individual differences, and training interventions
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5
Double responding: a new constraint for models of speeded decision making
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6
Diffusing the bilingual lexicon: Task-based and lexical components of language switch costs
Ong, Gabriel; McKague, Meredith; Weekes, Brendan. - : Academic Press, 2019
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7
The concept of regularization: resolving the problem of surface dyslexia in semantic variant primary progressive aphasia across different languages
Billette, Ornella V.; Preib, Daniel; Nestor, Peter J.. - : American Psychological Association, 2019
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8
Age-related differences in idea generation and selection for propositional language
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9
Category-length and category-strength effects using images of scenes
Baumann, Oliver; Vromen, Joyce M. G.; Boddy, Adam C.. - : Springer New York LLC, 2018
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10
The shape of things to come in speech production: visual form interference during lexical access
de Zubicaray, Greig I.; McLean, Mia; Oppermann, Frank. - : Sage Publications, 2018
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11
No lexical competition without priming: evidence from the picture–word interference paradigm
Gauvin, Hanna S.; Jonen, Magdalena K.; Choi, Jessica. - : Sage Publications, 2018
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12
Memory dysfunction in school-aged children exposed prenatally to antiepileptic drugs
Barton, Sarah; Nadebaum, Caroline; Anderson, Vicki A.. - : American Psychological Association, 2018
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13
Semantic Feature Disturbance in Alzheimer Disease: Evidence from an Object Decision Task
Flanagan, Kieran J.; Copland, David A.; Chenery, Helen J.. - : Lippincott Williams and Wilkins, 2017
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14
N400 and emotional word processing in Parkinson's disease
Dissanayaka, Nadeeka N. W.; Au, Tiffany R.; Angwin, Anthony J.. - : American Psychological Association, 2017
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15
Repetition blindness in priming in perceptual identification: Competitive effects of a word intervening between prime and target
Burt, Jennifer S.; Jolley, Jessica. - : Springer New York, 2017
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16
Semantic word category processing in semantic dementia and posterior cortical atrophy
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17
The locus of taboo context effects in picture naming
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18
Masked form priming is moderated by the size of the letter-order-free orthographic neighbourhood
Burt, Jennifer S.; Duncum, Sophie. - : Routledge, 2016
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19
Associations between inattention, hyperactivity and pre-reading skills before and after formal reading instruction begins
Dittman, Cassandra K.. - : Springer Netherlands, 2016
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20
Semantic feature training for the treatment of anomia in alzheimer disease: A preliminary investigation
Flanagan, Kieran J.; Copland, David A.; van Hees, Sophia. - : Lippincott Williams & Wilkins, 2016
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