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Nonverbal Auditory Cues Allow Relationship Quality to be Inferred During Conversations. ...
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LexiComWeb: donnees et executables. Synthèse de la communication web par le lexique ...
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LexiComWeb: donnees et executables. Synthèse de la communication web par le lexique ...
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Listening to Stakeholders Involved in Speech-Language Therapy for Children With Communication Disorders: Content Analysis of Apple App Store Reviews
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In: JMIR Pediatr Parent (2022)
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What Influences the Way Radiologists Express Themselves in Their Reports? A Quantitative Assessment Using Natural Language Processing
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In: J Digit Imaging (2022)
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Ageing and selective inhibition of irrelevant information in an attention-demanding rapid serial visual presentation task
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In: Brain Neurosci Adv (2022)
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Discussions and Misinformation About Electronic Nicotine Delivery Systems and COVID-19: Qualitative Analysis of Twitter Content
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In: JMIR Form Res (2022)
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The Influence of Face Masks on Verbal Communication in Persian in the Presence of Background Noise in Healthcare Staff
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In: Acoust Aust (2022)
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EfficientMask-Net for face authentication in the era of COVID-19 pandemic
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In: Signal Image Video Process (2022)
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Prioritizing Support Offered to Caregivers by Examining the Status Quo and Opportunities for Enhancement When Using Web-Based Self-reported Health Questionnaires: Descriptive Qualitative Study
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In: JMIR Form Res (2022)
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Identifying COVID-19 Outbreaks From Contact-Tracing Interview Forms for Public Health Departments: Development of a Natural Language Processing Pipeline
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In: JMIR Public Health Surveill (2022)
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Smartphone App–Based Noncontact Ecological Momentary Assessment With Experienced and Naïve Older Participants: Feasibility Study
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In: JMIR Form Res (2022)
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Facial and Vocal Markers of Schizophrenia Measured Using Remote Smartphone Assessments: Observational Study
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In: JMIR Form Res (2022)
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Exploring the Factors Affecting Behavioural Intention to Use Google Classroom: University Teachers’ Perspectives in Bangladesh and Nigeria
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In: TechTrends (2022)
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Social emotional ability development (SEAD): An integrated model of practical emotion-based competencies
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In: Motiv Emot (2022)
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Quantitative Measurement of Adult Human Larynx post General Anesthesia with Intubation
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In: Int J Med Sci (2022)
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Interpersonal Mindfulness Questionnaire: Scale Development and Validation
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In: Mindfulness (N Y) (2022)
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Students’ feedback experiences and expectations pre- and post-university entry
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In: SN Soc Sci (2022)
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NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation
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Huth, Michelle; Santini, Laura; Galimberti, Elena; Ramesmayer, Julia; Titz-Teixeira, Fabian; Sehlke, Robert; Oberhuemer, Michael; Stummer, Sarah; Herzog, Veronika; Garmhausen, Marius; Romeike, Merrit; Chugunova, Anastasia; Leesch, Friederike; Holcik, Laurenz; Weipoltshammer, Klara; Lackner, Andreas; Schoefer, Christian; von Haeseler, Arndt; Buecker, Christa; Pauli, Andrea; Ameres, Stefan L.; Smith, Austin; Beyer, Andreas; Leeb, Martin
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In: Genes Dev (2022)
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Abstract:
Cell fate transitions depend on balanced rewiring of transcription and translation programs to mediate ordered developmental progression. Components of the nonsense-mediated mRNA decay (NMD) pathway have been implicated in regulating embryonic stem cell (ESC) differentiation, but the exact mechanism is unclear. Here we show that NMD controls expression levels of the translation initiation factor Eif4a2 and its premature termination codon-encoding isoform (Eif4a2(PTC)). NMD deficiency leads to translation of the truncated eIF4A2(PTC) protein. eIF4A2(PTC) elicits increased mTORC1 activity and translation rates and causes differentiation delays. This establishes a previously unknown feedback loop between NMD and translation initiation. Furthermore, our results show a clear hierarchy in the severity of target deregulation and differentiation phenotypes between NMD effector KOs (Smg5 KO > Smg6 KO > Smg7 KO), which highlights heterodimer-independent functions for SMG5 and SMG7. Together, our findings expose an intricate link between mRNA homeostasis and mTORC1 activity that must be maintained for normal dynamics of cell state transitions.
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Keyword:
Research Paper
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URL: http://www.ncbi.nlm.nih.gov/pubmed/35241478 https://doi.org/10.1101/gad.347690.120 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973849/
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Understanding the #longCOVID and #longhaulers Conversation on Twitter: Multimethod Study
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In: JMIR Infodemiology (2022)
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