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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
Abstract: IntroductionThe Frontotemporal Lobar Degeneration Module (FTLD-MOD) includes a neuropsychological battery designed to assess the clinical features of FTLD, although much is unknown about its utility. We investigated FTLD-MOD and Uniform Data Set 3.0 (UDS) language tests for differential diagnosis and disease monitoring.MethodsLinear regressions compared baseline performances in 1655 National Alzheimer's Coordinating Center participants (behavioral variant frontotemporal dementia (bvFTD, n=612), semantic variant primary progressive aphasia (svPPA, n=168), non-fluent/agrammatic variant PPA (nfvPPA, n=168), logopenic variant PPA (lvPPA, n=109), and controls (n=581)). Sample sizes to detect treatment effects were estimated using longitudinal data.ResultsAmong PPAs, the FTLD-MOD language tasks and UDS Multilingual Naming Test accurately discriminated svPPA. Number Span Forward best discriminated lvPPA; Phonemic:Semantic Fluency ratio was excellent for nfvPPA classification. UDS fluency and naming measures required the smallest sample size to detect meaningful change.DiscussionThe FTLD-MOD and UDS differentiated among PPA subtypes. UDS 3.0 measures performed best for longitudinal monitoring.
Keyword: Acquired Cognitive Impairment; Aging; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease Related Dementias (ADRD); Aphasia; Brain Disorders; Clinical Research; clinical trials; Clinical Trials and Supportive Activities; cognition; Dementia; differential diagnosis; endpoints; frontotemporal dementia; Frontotemporal Dementia (FTD); FTLD module; Genetics; longitudinal; Neurodegenerative; neuropsychology; Neurosciences; primary progressive aphasia; Rare Diseases; speech
URL: https://escholarship.org/uc/item/31v6d3qh
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2
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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3
Dysfunctional tissue correlates of unrelated naming errors in acute left hemisphere stroke ...
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Dysfunctional tissue correlates of unrelated naming errors in acute left hemisphere stroke ...
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5
Treatment of post-stroke aphasia: A narrative review for stroke neurologists ...
Vitti, Emilia; Hillis, Argye E. - : SAGE Journals, 2021
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sj-pdf-1-wso-10.1177_17474930211017807 - Supplemental material for Treatment of post-stroke aphasia: A narrative review for stroke neurologists ...
Vitti, Emilia; Hillis, Argye E. - : SAGE Journals, 2021
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Treatment of post-stroke aphasia: A narrative review for stroke neurologists ...
Vitti, Emilia; Hillis, Argye E. - : SAGE Journals, 2021
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sj-pdf-1-wso-10.1177_17474930211017807 - Supplemental material for Treatment of post-stroke aphasia: A narrative review for stroke neurologists ...
Vitti, Emilia; Hillis, Argye E. - : SAGE Journals, 2021
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9
Protocol for Escitalopram and Language Intervention for Subacute Aphasia (ELISA): A randomized, double blind, placebo-controlled trial
In: PLoS One (2021)
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10
Executive control deficits and lesion correlates in acute left hemisphere stroke survivors with and without aphasia
In: Brain Imaging Behav (2021)
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11
Independent contributions of structural and functional connectivity: Evidence from a stroke model
In: Netw Neurosci (2021)
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12
Stroke Recurrence and Its Relationship With Language Abilities
In: J Speech Lang Hear Res (2021)
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13
One cat, Two cats, Red cat, Blue cats: Eliciting morphemes from individuals with primary progressive aphasia.
In: Aphasiology (2021)
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14
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring
In: Alzheimers Dement (Amst) (2021)
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15
Indirect white matter pathways are associated with treated naming improvement in aphasia
In: Neurorehabil Neural Repair (2021)
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16
Frontal Aslant Tracts as Correlates of Lexical Retrieval in MS
In: Neurol Res (2020)
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17
The Role of Microstructural Integrity of Major Language Pathways in Narrative Speech in the First Year after Stroke
In: J Stroke Cerebrovasc Dis (2020)
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18
White Matter Hyperintensities Contribute to Language Deficits in Primary Progressive Aphasia
In: Cogn Behav Neurol (2020)
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19
Is Aphasia Treatment Beneficial for the Elderly? A Review of Recent Evidence
In: Curr Phys Med Rehabil Rep (2020)
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20
An Efficient Bedside Measure Yields Prognostic Implications for Language Recovery in Acute Stroke Patients
In: Cogn Behav Neurol (2020)
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