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1
Dynamic functional brain network connectivity during pseudoword processing relates to children’s reading skill
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2
Understanding the Learning Experiences of Highly Educated refugees from Iraq and Syria en route to Economic Integration in Luxembourg
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3
Energy Conservation Theory for Second Language Acquisition (Ect-l2a): A Partial Validation of Kinetic Energy– Aptitude and Motivation
Kim, Peter. - 2022
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4
Family history of FXTAS is associated with age-related cognitive-linguistic decline among mothers with the FMR1 premutation.
In: Journal of neurodevelopmental disorders, vol 14, iss 1 (2022)
Abstract: BackgroundWomen who carry a premutation allele of the FMR1 gene are at increased vulnerability to an array of age-related symptoms and disorders, including age-related decline in select cognitive skills. However, the risk factors for age-related decline are poorly understood, including the potential role of family history and genetic factors. In other forms of pathological aging, early decline in syntactic complexity is observed and predicts the later onset of neurodegenerative disease. To shed light on the earliest signs of degeneration, the present study characterized longitudinal changes in the syntactic complexity of women with the FMR1 premutation across midlife, and associations with family history of fragile X-associated tremor/ataxia syndrome (FXTAS) and CGG repeat length.MethodsForty-five women with the FMR1 premutation aged 35-64years at study entry participated in 1-5 longitudinal assessments spaced approximately a year apart (130 observations total). All participants were mothers of children with confirmed fragile X syndrome. Language samples were analyzed for syntactic complexity and participants provided information on family history of FXTAS. CGG repeat length was determined via molecular genetic testing.ResultsHierarchical linear models indicated that women who reported a family history of FXTAS exhibited faster age-related decline in syntactic complexity than those without a family history, with that difference emerging as the women reached their mid-50s. CGG repeat length was not a significant predictor of age-related change.ConclusionsResults suggest that women with the FMR1 premutation who have a family history of FXTAS may be at increased risk for neurodegenerative disease, as indicated by age-related loss of syntactic complexity. Thus, family history of FXTAS may represent a personalized risk factor for age-related disease. Follow-up study is needed to determine whether syntactic decline is an early indicator of FXTAS specifically, as opposed to being a more general age-related cognitive decline associated with the FMR1 premutation.
Keyword: 2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Adult; Aging; Alleles; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Ataxia; Behavioral and Social Science; Brain Disorders; Child; Clinical Research; Cognitive Dysfunction; Dementia; Female; Fragile X Mental Retardation Protein; Fragile X premutation; Fragile X Syndrome; Genetics; Grammatical complexity; Humans; Intellectual and Developmental Disabilities (IDD); Language Disorders; Language production; Middle Aged; Mothers; Neurodegenerative; Neurodegenerative Diseases; Neurological; Neurosciences; Pediatric; Psychology; Rare Diseases; Tremor
URL: https://escholarship.org/uc/item/2m78r62b
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5
A Path to Decolonizing the Online Classroom
In: Northwest Journal of Teacher Education (2022)
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6
Examining the Perspectives of Adult Working Learners and Key Stakeholders Using Critical Race Theory
In: Applied Linguistics Faculty Publications and Presentations (2022)
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7
FEATURES OF ADULTS LEARNING FOREIGN LANGUAGE ...
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8
FEATURES OF ADULTS LEARNING FOREIGN LANGUAGE ...
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9
Supplemental materials for paper: The Critical Review to Practical Inquiries of Action Research Framework ...
sarbunan, thobias. - : Open Science Framework, 2022
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10
Assessing Cognitive Flexibility, Other Executive Functions, and Learning in Healthy Adolescents ...
Uchiyama, Ryutaro. - : Open Science Framework, 2022
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11
Cognitive Flexibility and Its Association with Linguistic Preferences, Decision-Making, Tolerance of Uncertainty and Perceived Social Support ...
Tong, Ke. - : Open Science Framework, 2022
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12
An Audibility Model of the Bone Conduction Device during Headband Trial in Single-sided Deaf Subjects. ...
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13
An Audibility Model of the Bone Conduction Device during Headband Trial in Single-sided Deaf Subjects. ...
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14
An Audibility Model of the Bone Conduction Device during Headband Trial in Single-sided Deaf Subjects. ...
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15
“Give me a path to follow”: A Deweyan inquiry into training volunteer EAL tutors of adult refugees
Enriquez Watt, Maria. - : Edith Cowan University, Research Online, Perth, Western Australia, 2022
In: Theses: Doctorates and Masters (2022)
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16
Health Care for Refugees in Europe: A Scoping Review
In: International Journal of Environmental Research and Public Health; Volume 19; Issue 3; Pages: 1278 (2022)
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17
A Model for Analyzing Teachers’ Written Feedback on Adult Beginners’ Writing in Swedish as a Second Language
In: Languages; Volume 7; Issue 2; Pages: 74 (2022)
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18
“Our Brokenness Kind of Connects Us”: Exploring Social Justice Topics Through Read-Alouds in a Ninth-Grade Classroom
Hoppe, Kayln. - 2022
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19
TEACHING ENGLISH THROUGH INTERACTIVE GAMES IN A HIGHER EDUCATIONAL ESTABLISHMENT ...
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20
TEACHING ENGLISH THROUGH INTERACTIVE GAMES IN A HIGHER EDUCATIONAL ESTABLISHMENT ...
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