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Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years. ...
Green, Jonathan; Pickles, Andrew; Pasco, Greg. - : Apollo - University of Cambridge Repository, 2017
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2
Early development of infants with neurofibromatosis type 1: a case series. ...
Kolesnik, Anna; Jones, Emily Jane Harrison; Garg, Shruti. - : Apollo - University of Cambridge Repository, 2017
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3
Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years.
British Autism Study of Infant Siblings (BASIS) Team; Charman, Tony; Jones, Emily. - : Wiley, 2017. : J Child Psychol Psychiatry, 2017
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Early development of infants with neurofibromatosis type 1: a case series.
Kolesnik, Anna; Jones, Emily Jane Harrison; Garg, Shruti. - : Springer Science and Business Media LLC, 2017. : Mol Autism, 2017
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Randomised trial of a parent-mediated intervention for infants at high risk for autism: Longitudinal outcomes to age 3 years
Abstract: BACKGROUND: There has been increasing interest in the potential for pre-emptive interventions in the prodrome of autism, but little investigation as to their effect. METHODS: A two-site, two-arm assessor-blinded randomised controlled trial (RCT) of a 12-session parent-mediated social communication intervention delivered between 9 and 14 months of age (Intervention in the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive Parenting), against no intervention. Fifty-four infants (28 intervention, 26 nonintervention) at familial risk of autism but not otherwise selected for developmental atypicality were assessed at 9-month baseline, 15-month treatment endpoint, and 27- and 39-month follow-up. PRIMARY OUTCOME: severity of autism prodromal symptoms, blind-rated on Autism Observation Schedule for Infants or Autism Diagnostic Observation Schedule 2nd Edition across the four assessment points. SECONDARY OUTCOMES: blind-rated parent-child interaction and child language; nonblind parent-rated communication and socialisation. Prespecified intention-to-treat analysis combined estimates from repeated measures within correlated regressions to estimate the overall effect of the infancy intervention over time. RESULTS: Effect estimates in favour of intervention on autism prodromal symptoms, maximal at 27 months, had confidence intervals (CIs) at each separate time point including the null, but showed a significant overall effect over the course of the intervention and follow-up period (effect size [ES] = 0.32; 95% CI 0.04, 0.60; p = .026). Effects on proximal intervention targets of parent nondirectiveness/synchrony (ES = 0.33; CI 0.04, 0.63; p = .013) and child attentiveness/communication initiation (ES = 0.36; 95% CI 0.04, 0.68; p = .015) showed similar results. There was no effect on categorical diagnostic outcome or formal language measures. CONCLUSIONS: Follow-up to 3 years of the first RCT of a very early social communication intervention for infants at familial risk of developing autism has shown a treatment effect, extending 24 months after intervention end, to reduce the overall severity of autism prodromal symptoms and enhance parent-child dyadic social communication over this period. We highlight the value of extended follow-up and repeat assessment for early intervention trials.
URL: https://ueaeprints.uea.ac.uk/id/eprint/75581/
https://doi.org/10.1111/jcpp.12728
https://ueaeprints.uea.ac.uk/id/eprint/75581/1/Published_Version.pdf
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6
Early development of infants with neurofibromatosis type 1: A case series
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7
Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years
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8
Outlier Spaces: Obstructions
Green, Jonathan. - : University of Alberta, 2016
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9
Outlier Spaces: Obstructions
Green, Jonathan. - 2016
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10
Transfer of learning and the cultural matrix: culture, beliefs and learning in Thailand higher education
Green, Jonathan H.. - : Deep University Press, 2015
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11
Social communication disorder outside autism? A diagnostic classification approach to delineating pragmatic language impairment, high functioning autism and specific language impairment
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12
Burdens of proof and the case for unevenness
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13
The Social Communication Intervention Project: a randomized controlled trial of the effectiveness of speech and language therapy for school-age children who have pragmatic and social communication problems with or without autism spectrum disorder
In: International journal of language & communication disorders. - Oxford : Wiley-Blackwell 47 (2012) 3, 233-244
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14
Individual common variants exert weak effects on the risk for autism spectrum disorders.
In: Human molecular genetics, vol 21, iss 21 (2012)
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15
Individual common variants exert weak effects on the risk for autism spectrum disorders.
In: ISSN: 0964-6906 ; EISSN: 1460-2083 ; Human Molecular Genetics ; https://www.hal.inserm.fr/inserm-00723650 ; Human Molecular Genetics, Oxford University Press (OUP), 2012, 21 (21), pp.4781-92. ⟨10.1093/hmg/dds301⟩ (2012)
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Individual common variants exert weak effects on the risk for autism spectrum disorders ...
Folstein, Susan E.; Crawford, Emily L.; Glessner, Joseph T.. - : The University of North Carolina at Chapel Hill University Libraries, 2012
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17
Individual common variants exert weak effects on the risk for autism spectrum disorders
Anney, Richard; Klei, Lambertus; Pinto, Dalila. - : Oxford University Press, 2012
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18
Individual common variants exert weak effects on risk for Autism Spectrum Disorders
Anney, Richard; Klei, Lambertus; Pinto, Dalila. - : Oxford University Press, 2012
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19
Individual common variants exert weak effects on the risk for autism spectrum disorderspi
Anney, Richard; Klei, Lambertus; Pinto, Dalila. - : Oxford University Press, 2012
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20
Individual common variants exert weak effects on the risk for autism spectrum disorderspi
Anney, Richard; Klei, Lambertus; Pinto, Dalila. - : Oxford University Press, 2012
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