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1	Examining the presence and nature of delusions in Alzheimer's disease and frontotemporal dementia syndromes
	Kumfor, Fiona; Liang, Cheng Tao; Hazelton, Jessica L.; Leyton, Cristian E.; Kaizik, Cassandra; Devenney, Emma; Connaughton, Emily; Langdon, Robyn; Mioshi, Eneida; Kwok, John B.; Dobson-Stone, Carol; Halliday, Glenda M.; Piguet, Olivier; Hodges, John R.; Landin-Romero, Ramon. - 2022
	Abstract: Objectives Abnormal beliefs and delusions have been reported in some people with dementia, however, the prevalence of delusions, and their neurocognitive basis has been underexplored. This study aimed to examine the presence, severity, content and neural correlates of delusions in a large, well-characterised cohort of dementia patients using a transdiagnostic, cross-sectional approach. Methods Four-hundred and eighty-seven people with dementia were recruited: 102 Alzheimer's disease, 136 behavioural-variant frontotemporal dementia, 154 primary progressive aphasia, 29 motor neurone disease, 46 corticobasal syndrome, 20 progressive supranuclear palsy. All patients underwent neuropsychological assessment and brain magnetic resonance imaging, and the Neuropsychiatric Inventory was conducted with an informant, by an experienced clinician. Results In our cohort, 48/487 patients (10.8%) had delusions. A diagnosis of behavioural-variant frontotemporal dementia (18.4%) and Alzheimer's disease (11.8%) were associated with increased risk of delusions. A positive gene mutation was observed in 11/27 people with delusions. Individuals with frequent delusions performed worse on the Addenbrooke's Cognitive Examination (p = 0.035), particularly on the orientation/attention (p = 0.022) and memory (p = 0.013) subtests. Voxel-based morphometry analyses found that increased delusional psychopathology was associated with reduced integrity of the right middle frontal gyrus, right planum temporale and left anterior temporal pole. Conclusion Our results demonstrate that delusions are relatively common in dementia and uncover a unique cognitive and neural profile associated with the manifestation of delusions. Clinically, delusions may lead to delayed or misdiagnosis. Our results shed light on how to identify individuals at risk of neuropsychiatric features of dementia, a crucial first step to enable targeted symptom management.
	URL: https://ueaeprints.uea.ac.uk/id/eprint/83699/1/Published_Version.pdf https://doi.org/10.1002/gps.5692 https://ueaeprints.uea.ac.uk/id/eprint/83699/
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2	The Role of White Matter Dysfunction and Leukoencephalopathy/Leukodystrophy Genes in the Aetiology of Frontotemporal Dementias: Implications for Novel Approaches to Therapeutics
	Lok, Hiu Chuen; Kwok, John B.
	In: Int J Mol Sci (2021)
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3	Novel genetic loci associated with hippocampal volume
	Hibar, Derrek P.; Adams, Hieab H. H.; Jahanshad, Neda...
	In: ISSN: 2041-1723 ; EISSN: 2041-1723 ; Nature Communications ; https://hal.archives-ouvertes.fr/hal-01488337 ; Nature Communications, Nature Publishing Group, 2017, 8, pp.13624. ⟨10.1038/ncomms13624⟩ (2017)
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4	Novel genetic loci underlying human intracranial volume identified through genome-wide association
	Adams, Hieab H H; Hibar, Derrek P; Chouraki, Vincent...
	In: ISSN: 1097-6256 ; EISSN: 1546-1726 ; Nature Neuroscience ; https://hal.archives-ouvertes.fr/hal-01382716 ; Nature Neuroscience, Nature Publishing Group, 2016, 19 (12), pp.1569-1582. ⟨10.1038/nn.4398⟩ (2016)
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5	Common genetic variants influence human subcortical brain structures.
	Hibar, Derrek P; Stein, Jason L; Renteria, Miguel E...
	In: ISSN: 0028-0836 ; EISSN: 1476-4679 ; Nature ; https://hal.archives-ouvertes.fr/hal-01196805 ; Nature, Nature Publishing Group, 2015, 520 (7546), pp.224-9. ⟨10.1038/nature14101⟩ (2015)
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6	Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model
	Dang, Theresa N. T.; Dobson-Stone, Carol; Glaros, Elias N.. - : The Company of Biologists Limited, 2013
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