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Primary intracranial dural lymphoma of mucosa-associated lymphoid tissue (MALT) type: report of one case and review of the literature.
In: Bulletin du Cancer, vol. 92, no. 7, pp. E51-E56 (2005)
Abstract: Primary indolent leptomeningeal lymphoma is a rare entity, and corresponds in most cases to mucosa-associated lymphoid tissue (MALT) type lymphoma. We are reporting a case of a 75 years old woman, who presented with a 2-year history of behavioral disorder, progressive memory loss and aphasia. Neuroimaging showed a mass infiltrating the frontal circumvolutions and the roof of the orbit. The biopsy revealed an infiltration of the dura by an indolent lymphoma, characteristic of a MALT-type lymphoma. Complete staging work-up did not show any evidence of systemic involvement. A treatment with systemic methotrexate, combined with intrathecal chemotherapy and followed by radiotherapy (30,6 Gy) of the primary site, was conducted. The 3-year follow-up confirms the persistent remission, the patient remaining well and free of symptoms. The review of the literature highlights the importance to recognize the indolent PLML as a distinct clinical entity, which exhibits a rather good prognosis following a relatively non-toxic therapy.
Keyword: Aged; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; B-Cell; Combined Modality Therapy; Cytarabine/administration & dosage; Dura Mater; Female; Humans; Hydrocortisone/administration & dosage; Lymphoma; Marginal Zone/cerebrospinal fluid; Marginal Zone/pathology; Meningeal Neoplasms/cerebrospinal fluid; Meningeal Neoplasms/pathology; Methotrexate/administration & dosage
URL: https://serval.unil.ch/notice/serval:BIB_D234D3407DDA
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