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Primary intracranial dural lymphoma of mucosa-associated lymphoid tissue (MALT) type: report of one case and review of the literature.
George, A.C.
;
Ozsahin, M.
;
Janzer, R.
;
Agassis, S.
;
Meuli, R.
;
Baur, A.S.
;
Frossard, V.
;
Leyvraz, S.
;
Ketterer, N.
In: Bulletin du Cancer, vol. 92, no. 7, pp. E51-E56 (2005)
Abstract:
Primary indolent leptomeningeal lymphoma is a rare entity, and corresponds in most cases to mucosa-associated lymphoid tissue (MALT) type lymphoma. We are reporting a case of a 75 years old woman, who presented with a 2-year history of behavioral disorder, progressive memory loss and aphasia. Neuroimaging showed a mass infiltrating the frontal circumvolutions and the roof of the orbit. The biopsy revealed an infiltration of the dura by an indolent lymphoma, characteristic of a MALT-type lymphoma. Complete staging work-up did not show any evidence of systemic involvement. A treatment with systemic methotrexate, combined with intrathecal chemotherapy and followed by radiotherapy (30,6 Gy) of the primary site, was conducted. The 3-year follow-up confirms the persistent remission, the patient remaining well and free of symptoms. The review of the literature highlights the importance to recognize the indolent PLML as a distinct clinical entity, which exhibits a rather good prognosis following a relatively non-toxic therapy.
Keyword:
Aged
;
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
;
B-Cell
;
Combined Modality Therapy
;
Cytarabine/administration & dosage
;
Dura Mater
;
Female
;
Humans
;
Hydrocortisone/administration & dosage
;
Lymphoma
;
Marginal Zone/cerebrospinal fluid
;
Marginal Zone/pathology
;
Meningeal Neoplasms/cerebrospinal fluid
;
Meningeal Neoplasms/pathology
;
Methotrexate/administration & dosage
URL:
https://serval.unil.ch/notice/serval:BIB_D234D3407DDA
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