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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 12 of 12 1 Changing the face of neuroimaging research: Comparing a new MRI de-facing technique with popular alternatives Schwarz, Christopher G.; Kremers, Walter K.; Wiste, Heather J.... In: Neuroimage (2021) BASE Show details 2 A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech Josephs, Keith A.; Duffy, Joseph R.; Clark, Heather M.... In: Nat Commun (2021) BASE Show details 3 Association of amyloid angiopathy with microbleeds in logopenic progressive aphasia: an imaging-pathology study Buciuc, Marina; Duffy, Joseph R.; Machulda, Mary M.; Spychalla, Anthony J.; Gunter, Jeffrey L.; Jack, Clifford R.; Giannini, Caterina; Raghunathan, Aditya; Dickson, Dennis W.; Josephs, Keith A.; Whitwell, Jennifer L. In: Eur J Neurol (2020) Abstract: BACKGROUND: Cerebral microbleeds (MB) and superficial siderosis (SS) are frequent neuroimaging findings in patients with logopenic progressive aphasia (LPA), often with frontal lobe predilection. Cerebral amyloid angiopathy (CAA) is hypothesized to be the major pathologic determinant of MB/SS in these patients; however, neuroimaging-pathologic data are limited. METHODS: All patients who had been prospectively recruited by the Neurodegenerative Research Group at Mayo Clinic (Rochester, MN) between 2010 and 2015 that met the following inclusion criteria were included: 1) received an antemortem LPA diagnosis; 2) had a gradient-recalled echo (GRE) T2-weighted magnetic resonance imaging (MRI) performed; 3) died and completed a brain autopsy. Demographic, genetic, neuroimaging, clinical and pathologic characteristics were compared between patients with/without MB/SS. Two-tailed Fisher’s Exact and Wilcoxon rank sum tests were used for comparison of categorical and continuous variables, respectively. RESULTS: Thirteen patients met inclusion criteria, six (46%) had MB/SS on MRI. Moderate/severe CAA was associated with the presence of MB/SS, p=0.029. As expected, MB/SS most frequently involved the frontal lobes, followed by the parietal lobes. No clear associations were found between regional MB/SS distribution and regional distribution of CAA or hypometabolism on [(18)F]-fluorodeoxyglucose PET. There was some evidence for a regional association between MB/SS and uptake on Pittsburgh compound B although not in all patients. No formal statistical analyses to assess topographic relationships were performed due to small sample size. CONCLUSIONS: The presence of MB/SS is a strong indicator of underlying moderate/severe CAA in LPA, although the biological mechanisms underlying the topographic distribution of MB/SS remain unclear. Keyword: Article URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174551/ https://doi.org/10.1111/ene.14594 http://www.ncbi.nlm.nih.gov/pubmed/33068458 BASE Hide details 4 Longitudinal anatomic, functional, and molecular characterization of Pick disease phenotypes Whitwell, Jennifer L.; Tosakulwong, Nirubol; Schwarz, Christopher C.... In: Neurology (2020) BASE Show details 5 An Evaluation of the Progressive Supranuclear Palsy Speech/Language Variant Whitwell, Jennifer L.; Stevens, Chase A.; Duffy, Joseph R.... In: Mov Disord Clin Pract (2019) BASE Show details 6 Clinical and Neuroimaging Characteristics of Clinically Unclassifiable Primary Progressive Aphasia Utianski, Rene L.; Botha, Hugo; Martin, Peter R.... In: Brain Lang (2019) BASE Show details 7 Longitudinal structural and molecular neuroimaging in agrammatic primary progressive aphasia Tetzloff, Katerina A; Duffy, Joseph R; Clark, Heather M. - : Oxford University Press, 2018 BASE Show details 8 Prosodic and Phonetic Subtypes of Primary Progressive Apraxia of Speech Utianski, Rene L.; Duffy, Joseph R.; Clark, Heather M.. - 2018 BASE Show details 9 Predicting clinical decline in progressive agrammatic aphasia and apraxia of speech Whitwell, Jennifer L.; Weigand, Stephen D.; Duffy, Joseph R.. - : Lippincott Williams & Wilkins, 2017 BASE Show details 10 Varying degrees of temporoparietal hypometabolism on FDG-PET reveal amyloid-positive logopenic primary progressive aphasia is not a homogeneous clinical entity Krishnan, Kamini; Machulda, Mary M.; Whitwell, Jennifer L.. - 2017 BASE Show details 11 Tracking the Development of Agrammatic Aphasia: a Tensor-Based Morphometry Study Whitwell, Jennifer L.; Duffy, Joseph R.; Machulda, Mary M.. - 2016 BASE Show details 12 Classification and clinicoradiologic features of primary progressive aphasia (PPA) and apraxia of speech Botha, Hugo; Duffy, Joseph R.; Whitwell, Jennifer L.. - 2015 BASE Show details

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