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Ischemic Optic Neuropathy After Administration of a SARS-CoV-2 Vaccine: A Report of 2 Cases
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In: Am J Case Rep (2022)
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Vitreous and Optic Nerve Infiltration of an Adrenal B Lymphoma
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In: Case Rep Ophthalmol (2021)
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Plasma Rich in Growth Factors (PRGF) Increases the Number of Retinal Müller Glia in Culture but Not the Survival of Retinal Neurons
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In: Front Pharmacol (2021)
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Remote screening of retinal and optic disc diseases using handheld nonmydriatic cameras in programmed routine occupational health checkups onsite at work centers
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In: Graefes Arch Clin Exp Ophthalmol (2020)
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Systemic Regulatory T Cells and IL-6 as Prognostic Factors for Anatomical Improvement of Uveitic Macular Edema
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Matas, Jessica; Llorenç, Victor; Fonollosa, Alex; Díaz-Valle, David; Esquinas, Cristina; de la Maza, Maria Teresa Sainz; Figueras-Roca, Marc; Artaraz, Joseba; Berasategui, Barbara; Mesquida, Marina; Adán, Alfredo; Molins, Blanca
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In: Front Immunol (2020)
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Abstract:
PURPOSE: To investigate whether systemic immune mediators and circulating regulatory T cells (Tregs) could be prognostic factors for anatomic outcomes in macular edema secondary to non-infectious uveitis (UME). METHODS: Multicenter, prospective, observational, 12-month follow-up study of 60 patients with UME. Macular edema was defined as central subfield thickness (CST) > 300 μm measured with spectral domain optical coherence tomography (SD-OCT). Serum samples and peripheral blood mononuclear cells (PBMC) were obtained from venous blood extraction at baseline. Serum levels of IL-1β, IL-6, IL-8, IL-17, MCP-1, TNF-α, IL-10, and VEGF were determined by Luminex. Tregs population, defined as CD3(+)CD4(+)FoxP3(+) in PBMC, was determined by flow cytometry. Main outcome measure was the predictive association between searched mediators and CST sustained improvement, defined as CST < 300 microns or a 20% CST decrease, at 6 months maintained until 12-months compared to baseline levels. RESULTS: Multivariate logistic regression analysis showed an association between CST sustained improvement at 12 months follow-up and IL-6 and Tregs baseline levels. Higher IL-6 levels were associated with less events of UME improvement (OR: 0.67, 95% CI (0.45–1.00), P = 0.042), whereas higher levels of Tregs favored such improvement (OR: 1.25, 95% CI: 1.12–2.56, P = 0.049). CONCLUSIONS: Increased levels of Tregs and reduced levels of IL-6 in serum may be prognostic factors of sustained anatomical improvement in UME. These findings could enforce the opportunity to develop more efficient and personalized therapeutic approaches to improve long-term visual prognosis in patients with UME.
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Keyword:
Immunology
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545109/
https://doi.org/10.3389/fimmu.2020.579005
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Paraneoplastic Focal Outer Retinitis and Optic Neuropathy in a Patient with Small Cell Lung Carcinoma and Anti-CRMP5, Anti-HU and Anti-Amphiphysin Antibodies
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In: Case Rep Ophthalmol (2020)
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Current ophthalmology practice patterns for syphilitic uveitis
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| 8 |
Predictors for functional and anatomic outcomes in macular edema secondary to non-infectious uveitis
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| 9 |
Predictors for functional and anatomic outcomes in macular edema secondary to non-infectious uveitis
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| 10 |
Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study
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Dexamethasone protects retinal ganglion cells but not Müller glia against hyperglycemia in vitro
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Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study
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| 13 |
Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study
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Dabrafenib for cutaneous melanoma infiltrating the vitreous: regression of metastasis and occurrence of uveitis as a secondary effect
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Dexamethasone intravitreal implants in the management of tubercular multifocal serpiginoid choroiditis
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Development of an activity disease score in patients with uveitis (UVEDAI)
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Usefulness of Adalimumab in the Treatment of Refractory Uveitis Associated with Juvenile Idiopathic Arthritis
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INSULIN RESISTANCE AND DIABETIC MACULAR EDEMA IN TYPE 2 DIABETES MELLITUS
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In: ISSN: 0007-1161 ; EISSN: 1468-2079 ; British Journal of Ophthalmology ; https://hal.archives-ouvertes.fr/hal-00557345 ; British Journal of Ophthalmology, BMJ Publishing Group, 2010, 94 (9), pp.1230. ⟨10.1136/bjo.2009.171702⟩ (2010)
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Insulin resistance and diabetic macular oedema in type 2 diabetes mellitus
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| 20 |
Insulin resistance and diabetic macular oedema in type 2 diabetes mellitus
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