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Aphasia outcome: the interactions between initial severity, lesion size and location
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In: ISSN: 0340-5354 ; EISSN: 1432-1459 ; Journal of Neurology ; https://hal.inria.fr/hal-02418331 ; Journal of Neurology, Springer Verlag, 2019, 266 (6), pp.1303-1309. ⟨10.1007/s00415-019-09259-3⟩ (2019)
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Predictive Factors of Swallowing Disorders and Bronchopneumonia in Acute Ischemic Stroke.
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In: Journal of stroke and cerebrovascular diseases, vol. 28, no. 8, pp. 2148-2154 (2019)
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Measuring quality of life in the speaker with dysarthria : Reliability and validity of the european Portuguese version of the qol-dys
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Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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Children with mixed developmental language disorder have more insecure patterns of attachment.
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In: BMC psychology, vol. 6, no. 1, pp. 54 (2018)
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Auditory processing deficits are sometimes necessary and sometimes sufficient for language difficulties in children: Evidence from mild to moderate sensorineural hearing loss. ...
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Auditory processing deficits are sometimes necessary and sometimes sufficient for language difficulties in children: Evidence from mild to moderate sensorineural hearing loss.
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Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults With Eosinophilic Esophagitis.
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In: Gastroenterology, vol. 150, no. 3, pp. 581-590.e4 (2016)
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Bilateral transcranial direct current stimulation language treatment enhances functional connectivity in the left hemisphere: Preliminary data from aphasia
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Using the Bayley-III to assess neurodevelopmental delay: which cut-off should be used?
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Johnson, Samantha; Moore, T.; Marlow, N.. - : Nature Publishing Group for American Pediatric Society, European Society for Paediatric Research, International Pediatric Research Foundation, Society for Pediatric Research (SPR), European Paediatric Research Society (ESPR), 2015
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Eosinophilic oesophagitis: relationship of quality of life with clinical, endoscopic and histological activity.
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In: Alimentary Pharmacology and Therapeutics, vol. 42, no. 8, pp. 1000-1010 (2015)
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Artificial grammar learning in individuals with severe aphasia.
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In: Neuropsychologia , 53 25 - 38. (2014) (2014)
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Processing of phonological variation in children with hearing loss: compensation for English place assimilation in connected speech.
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In: J Speech Lang Hear Res , 57 (3) 1127 - 1134. (2014) (2014)
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Cultural responses to pain in UK children of primary school age: a mixed-methods study.
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Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism
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El-Kordi, Ahmed; Winkler, Daniela; Hammerschmidt, Kurt; Kästner, Anne; Krueger, Dilja; Ronnenberg, Anja; Ritter, Caroline; Jatho, Jasmin; Radyushkin, Konstantin; Bourgeron, Thomas; Fischer, Julia; Brose, Nils; Ehrenreich, Hannelore
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In: ISSN: 0166-4328 ; EISSN: 1872-7549 ; Behavioural Brain Research ; https://hal-pasteur.archives-ouvertes.fr/pasteur-01580131 ; Behavioural Brain Research, Elsevier, 2013, 251 (1), pp.41 - 49. ⟨10.1016/j.bbr.2012.11.016⟩ (2013)
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Abstract:
International audience ; Autism is the short name of a complex and heterogeneous group of disorders (autism spectrum disorders, ASD) with several lead symptoms required for classification, including compromised social interaction, reduced verbal communication and stereotyped repetitive behaviors/restricted interests. The etiology of ASD is still unknown in most cases but monogenic heritable forms exist that have provided insights into ASD pathogenesis and have led to the notion of autism as a 'synapse disorder'. Among the most frequent monogenic causes of autism are loss-of-function mutations of the NLGN4X gene which encodes the synaptic cell adhesion protein neuroligin-4X (NLGN4X). We previously described autism-like behaviors in male Nlgn4 null mutant mice, including reduced social interaction and ultrasonic communication. Here, we extend the phenotypical characterization of Nlgn4 null mutant mice to both genders and add a series of additional autism-relevant behavioral readouts. We now report similar social interaction and ultrasonic communication deficits in females as in males. Furthermore, aggression, nest-building parameters, as well as self-grooming and circling as indicators of repetitive behaviors/stereotypies were explored in both genders. The construction of a gender-specific autism severity composite score for Nlgn4 mutant mice markedly diminishes population/sample heterogeneity typically obtained for single tests, resulting in p values of <0.00001 and a genotype predictability of 100% for male and of >83% for female mice. Taken together, these data underscore the similarity of phenotypical consequences of Nlgn4/NLGN4X loss-of-function in mouse and man, and emphasize the high relevance of Nlgn4 null mutant mice as an ASD model with both construct and face validity.
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Keyword:
[SCCO]Cognitive science; [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health; [SDV]Life Sciences [q-bio]; Animal; ASD; Gender differences; Grooming; Knockout; MESH: Animals; MESH: Autistic Disorder; MESH: Behavior; MESH: Carrier Proteins; MESH: Cell Adhesion Molecules; MESH: Disease Models; MESH: Female; MESH: Genetic Predisposition to Disease; MESH: Grooming; MESH: Male; MESH: Membrane Proteins; MESH: Mice; MESH: Phenotype; MESH: Severity of Illness Index; MESH: Sex Characteristics; MESH: Social Behavior; MESH: Stereotyped Behavior; MESH: Vocalization; Nest building; Neuronal; Repetitive behaviors; Social interaction; Stereotypies; Ultra-sound vocalization
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URL: https://doi.org/10.1016/j.bbr.2012.11.016 https://hal-pasteur.archives-ouvertes.fr/pasteur-01580131
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Mild aphasia: is this the place for an argument?
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In: Research outputs 2013 (2013)
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Atomoxetine improved attention in children and adolescents with attention-deficit/hyperactivity disorder and dyslexia in a 16 week, acute, randomized, double-blind trial
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In: PMC (2013)
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Procedures used for assessment of stuttering frequency and stuttering duration.
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In: Clin Linguist Phon , 27 (12) 853 - 861. (2013) (2013)
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