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Aphasia outcome: the interactions between initial severity, lesion size and location
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In: ISSN: 0340-5354 ; EISSN: 1432-1459 ; Journal of Neurology ; https://hal.inria.fr/hal-02418331 ; Journal of Neurology, Springer Verlag, 2019, 266 (6), pp.1303-1309. ⟨10.1007/s00415-019-09259-3⟩ (2019)
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Predictive Factors of Swallowing Disorders and Bronchopneumonia in Acute Ischemic Stroke.
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In: Journal of stroke and cerebrovascular diseases, vol. 28, no. 8, pp. 2148-2154 (2019)
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Measuring quality of life in the speaker with dysarthria : Reliability and validity of the european Portuguese version of the qol-dys
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Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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Santos-Santos, Miguel A; Rabinovici, Gil D; Iaccarino, Leonardo; Ayakta, Nagehan; Tammewar, Gautam; Lobach, Iryna; Henry, Maya L; Hubbard, Isabel; Mandelli, Maria Luisa; Spinelli, Edoardo; Miller, Zachary A; Pressman, Peter S; O'Neil, James P; Ghosh, Pia; Lazaris, Andreas; Meyer, Marita; Watson, Christa; Yoon, Soo Jin; Rosen, Howard J; Grinberg, Lea; Seeley, William W; Miller, Bruce L; Jagust, William J; Gorno-Tempini, Maria Luisa
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In: JAMA neurology, vol 75, iss 3 (2018)
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Abstract:
Importance:The ability to predict the pathology underlying different neurodegenerative syndromes is of critical importance owing to the advent of molecule-specific therapies. Objective:To determine the rates of positron emission tomography (PET) amyloid positivity in the main clinical variants of primary progressive aphasia (PPA). Design, Setting, and Participants:This prospective clinical-pathologic case series was conducted at a tertiary research clinic specialized in cognitive disorders. Patients were evaluated as part of a prospective, longitudinal research study between January 2002 and December 2015. Inclusion criteria included clinical diagnosis of PPA; availability of complete speech, language, and cognitive testing; magnetic resonance imaging performed within 6 months of the cognitive evaluation; and PET carbon 11-labeled Pittsburgh Compound-B or florbetapir F 18 brain scan results. Of 109 patients referred for evaluation of language symptoms who underwent amyloid brain imaging, 3 were excluded because of incomplete language evaluations, 5 for absence of significant aphasia, and 12 for presenting with significant initial symptoms outside of the language domain, leaving a cohort of 89 patients with PPA. Main Outcomes and Measures:Clinical, cognitive, neuroimaging, and pathology results. Results:Twenty-eight cases were classified as imaging-supported semantic variant PPA (11 women [39.3%]; mean [SD] age, 64 [7] years), 31 nonfluent/agrammatic variant PPA (22 women [71.0%]; mean [SD] age, 68 [7] years), 26 logopenic variant PPA (17 women [65.4%]; mean [SD] age, 63 [8] years), and 4 mixed PPA cases. Twenty-four of 28 patients with semantic variant PPA (86%) and 28 of 31 patients with nonfluent/agrammatic variant PPA (90%) had negative amyloid PET scan results, while 25 of 26 patients with logopenic variant PPA (96%) and 3 of 4 mixed PPA cases (75%) had positive scan results. The amyloid positive semantic variant PPA and nonfluent/agrammatic variant PPA cases with available autopsy data (2 of 4 and 2 of 3, respectively) all had a primary frontotemporal lobar degeneration and secondary Alzheimer disease pathologic diagnoses, whereas autopsy of 2 patients with amyloid PET-positive logopenic variant PPA confirmed Alzheimer disease. One mixed PPA patient with a negative amyloid PET scan had Pick disease at autopsy. Conclusions and Relevance:Primary progressive aphasia variant diagnosis according to the current classification scheme is associated with Alzheimer disease biomarker status, with the logopenic variant being associated with carbon 11-labeled Pittsburgh Compound-B positivity in more than 95% of cases. Furthermore, in the presence of a clinical syndrome highly predictive of frontotemporal lobar degeneration pathology, biomarker positivity for Alzheimer disease may be associated more with mixed pathology rather than primary Alzheimer disease.
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Keyword:
Aged; Amyloid; Aniline Compounds; Aphasia; Brain; Ethylene Glycols; Female; Humans; Imaging; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Primary Progressive; Retrospective Studies; Severity of Illness Index; Thiazoles; Three-Dimensional
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URL: https://escholarship.org/uc/item/1hm128x5
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Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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Children with mixed developmental language disorder have more insecure patterns of attachment.
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In: BMC psychology, vol. 6, no. 1, pp. 54 (2018)
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Auditory processing deficits are sometimes necessary and sometimes sufficient for language difficulties in children: Evidence from mild to moderate sensorineural hearing loss. ...
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| 8 |
Auditory processing deficits are sometimes necessary and sometimes sufficient for language difficulties in children: Evidence from mild to moderate sensorineural hearing loss.
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Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults With Eosinophilic Esophagitis.
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In: Gastroenterology, vol. 150, no. 3, pp. 581-590.e4 (2016)
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Bilateral transcranial direct current stimulation language treatment enhances functional connectivity in the left hemisphere: Preliminary data from aphasia
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Using the Bayley-III to assess neurodevelopmental delay: which cut-off should be used?
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Johnson, Samantha; Moore, T.; Marlow, N.. - : Nature Publishing Group for American Pediatric Society, European Society for Paediatric Research, International Pediatric Research Foundation, Society for Pediatric Research (SPR), European Paediatric Research Society (ESPR), 2015
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Eosinophilic oesophagitis: relationship of quality of life with clinical, endoscopic and histological activity.
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In: Alimentary Pharmacology and Therapeutics, vol. 42, no. 8, pp. 1000-1010 (2015)
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| 14 |
Artificial grammar learning in individuals with severe aphasia.
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In: Neuropsychologia , 53 25 - 38. (2014) (2014)
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Processing of phonological variation in children with hearing loss: compensation for English place assimilation in connected speech.
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In: J Speech Lang Hear Res , 57 (3) 1127 - 1134. (2014) (2014)
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Cultural responses to pain in UK children of primary school age: a mixed-methods study.
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| 17 |
Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism
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In: ISSN: 0166-4328 ; EISSN: 1872-7549 ; Behavioural Brain Research ; https://hal-pasteur.archives-ouvertes.fr/pasteur-01580131 ; Behavioural Brain Research, Elsevier, 2013, 251 (1), pp.41 - 49. ⟨10.1016/j.bbr.2012.11.016⟩ (2013)
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| 18 |
Mild aphasia: is this the place for an argument?
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In: Research outputs 2013 (2013)
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Atomoxetine improved attention in children and adolescents with attention-deficit/hyperactivity disorder and dyslexia in a 16 week, acute, randomized, double-blind trial
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In: PMC (2013)
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Procedures used for assessment of stuttering frequency and stuttering duration.
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In: Clin Linguist Phon , 27 (12) 853 - 861. (2013) (2013)
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