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Investigating the effects of noise exposure on self-report, behavioral and electrophysiological indices of hearing damage in musicians with normal audiometric thresholds
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Extended high frequency hearing and speech perception implications in adults and children
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In: Hear Res (2020)
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Effects of Age and Noise Exposure on Proxy Measures of Cochlear Synaptopathy
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Acoustic middle-ear-muscle-reflex thresholds in humans with normal audiograms:No relations to tinnitus, speech perception in noise, or noise exposure
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Timing Of Primary Surgery for cleft palate (TOPS): protocol for a randomised trial of palate surgery at 6 months versus 12 months of age
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Timing Of Primary Surgery for cleft palate (TOPS): protocol for a randomised trial of palate surgery at 6 months versus 12 months of age.
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Timing Of Primary Surgery for cleft palate (TOPS): protocol for a randomised trial of palate surgery at 6 months versus 12 months of age.
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Shaw, William; Semb, Gunvor; Lohmander, Anette; Persson, Christina; Willadsen, Elisabeth; Clayton-Smith, Jill; Trindade, Inge Kiemle; Munro, Kevin J; Gamble, Carrol; Harman, Nicola; Conroy, Elizabeth J; Weichart, Dieter; Williamson, Paula. - 2019
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Abstract:
INTRODUCTION:Cleft palate is among the most common birth abnormalities. The success of primary surgery in the early months of life is crucial for successful feeding, speech, hearing, dental development and facial growth. Over recent decades, age at palatal surgery in infancy has reduced. This has led to palatal closure in one-stage procedures being carried out around the age of 12 months, but in some cases as early as 6 months. The primary objective of the Timing Of Primary Surgery for Cleft Palate (TOPS)trial is to determine whether surgery for cleft palate performed at 6 or 12 months of age is most beneficial for speech outcomes. METHODS AND ANALYSIS:Infants with a diagnosis of non-syndromic isolated cleft palate will be randomised to receive standardised primary surgery (Sommerlad technique) for closure of the cleft at either 6 months or 12 months, corrected for gestational age. The primary outcome will be perceived insufficient velopharyngeal function at 5 years of age. Secondary outcomes measured across 12 months, 3 years and 5 years will include growth, safety of the procedure, dentofacial development, speech, hearing level and middle ear function. Video and audio recordings of speech will be collected in a standardised age-appropriate manner and analysed independently by multiple speech and language therapists. The trial aims to recruit and follow-up 300 participants per arm. Data will be analysed according to the intention-to-treat principle using a 5% significance level. All analyses will be prespecified within a full and detailed statistical analysis plan. ETHICS AND DISSEMINATION:Ethical approval has been sought in each participating country according to country-specific procedures. Trial results will be presented at conferences, published in peer-reviewed journals and disseminated through relevant patient support groups. TRIAL REGISTRATION NUMBER:NCT00993551; Pre-results.
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URL: http://livrepository.liverpool.ac.uk/3042221/1/submitted%20Protocol%20Paper%20BMJ%20Open%20-revised%2016052019.pdf
http://livrepository.liverpool.ac.uk/3042221/
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Impaired speech perception in noise with a normal audiogram:No evidence for cochlear synaptopathy and no relation to lifetime noise exposure
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| 9 |
Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure
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No evidence for enhanced processing of speech that is low-pass filtered near the edge frequency of cochlear dead regions in children
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| 11 |
Tinnitus and sleep difficulties after cochlear implantation
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Effects of broadband noise on cortical evoked auditory responses at different loudness levels in young adults
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| 13 |
The effect of low-pass filtering on identification of nonsense syllables in quiet by school-age children with and without cochlear dead regions
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Listening effort at signal-to-noise ratios that are typical of the school classroom
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| 15 |
Reorganization of the Adult Auditory System: Perceptual and Physiological Evidence From Monaural Fitting of Hearing Aids
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Reorganization of the Adult Auditory System: Perceptual and Physiological Evidence From Monaural Fitting of Hearing Aids
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