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ОБУЧЕНИ ДЕТЕЙ С ЗАДЕРЖКОЙ ПСИХИЧЕСКОГО РАЗВИТИЯ В СИСТЕМЕ КОРРЕКЦИОННО – ЛОГОПЕДИЧЕСКОЙ РАБОТЫ ... : TEACHING CHILDREN WITH MENTAL DEVELOPMENTAL DELAY IN THE SYSTEM OF CORRECTIVE LOGOPEDIC WORK ...
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Клинико-лингвистические характеристики психических нарушений при ВИЧ-инфицировании ... : Clinical and linguistic characteristics of mental disorders in HIV infection ...
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The Warnke Method for the Diagnosis and Improvement of Phonological Competence in Special Needs Children
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In: Education Sciences ; Volume 10 ; Issue 5 (2020)
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The neural underpinnings of shared meaning between speakers and listeners of naturalistic language ...
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Cognitive Working Memory Training (CWMT) in adolescents suffering from Attention-Deficit/Hyperactivity Disorder (ADHD): A controlled trial taking into account concomitant medication effects.
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In: Psychiatry research, vol. 269, pp. 79-85 (2018)
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Regional gray matter correlates of memory for emotion-laden words in middle-aged and older adults: A voxel-based morphometry study
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Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse
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Beyond the temporal pole - Limbic memory circuit in semantic variant of primary progressive aphasia
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Tan, Rachel H, Neuroscience Research Australia, Faculty of Medicine, UNSW; Wong, Stephanie, Neuroscience Research Australia, Barker Street, Randwick, Sydney, 2031, Australia; Kril, Jillian J, Disciplines of Pathology and Medicine, Sydney Medical School, The University of Sydney, 46. Sydney, 2006, Australia; Halliday, Glenda, Neuroscience Research Australia, Faculty of Medicine, UNSW; Piguet, Olivier, Neuroscience Research Australia, School of Medical Sciences, Faculty of Medicine, UNSW; Hornberger, Michael, Neuroscience Research Australia, School of Medical Sciences, Faculty of Medicine, UNSW; Hodges, John R, Neuroscience Research Australia, School of Medical Sciences, Faculty of Medicine, UNSW. - 2014
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Abstract:
Despite accruing evidence for relative preservation of episodic memory in the semantic variant of primary progressive aphasia (previously semantic dementia), the neural basis for this remains unclear, particularly in light of their well-established hippocampal involvement. We recently investigated the Papez network of memory structures across pathological subtypes of behavioral variant frontotemporal dementia and demonstrated severe degeneration of all relay nodes, with the anterior thalamus in particular emerging as crucial for intact episodic memory. The present study investigated the status of key components of Papez circuit (hippocampus, mammillary bodies, anterior thalamus, cingulate cortex) and anterior temporal cortex using volumetric and quantitative cell counting methods in pathologically-confirmed cases with semantic variant of primary progressive aphasia (n=8; 61-83 years; 3 males), behavioral variant frontotemporal dementia with TDP pathology (n=9; 53-82 years; 6 males) and healthy controls (n=8, 50-86 years; 4 males). Behavioral variant frontotemporal dementia cases with TDP pathology were selected because of the association between the semantic variant of primary progressive aphasia and TDP pathology. Our findings revealed that the semantic variant of primary progressive aphasia and behavioral variant frontotemporal dementia show similar degrees of anterior thalamic atrophy. The mammillary bodies and hippocampal body and tail were preserved in the semantic variant of primary progressive aphasia but were significantly atrophic in behavioral variant frontotemporal dementia. Importantly, atrophy in the anterior thalamus and mild progressive atrophy in the body of the hippocampus emerged as the main memory circuit regions correlated with increasing dementia severity in the semantic variant of primary progressive aphasia. Quantitation of neuronal populations in the cingulate cortices confirmed the selective loss of anterior cingulate Von Economo neurons in behavioral variant frontotemporal dementia. We also show that by end-stage these neurons selectively degenerate in the semantic variant of primary progressive aphasia with preservation of neurons in the posterior cingulate cortex. Overall, our findings demonstrate for the first time, severe atrophy, although not necessarily neuronal loss, across all relay nodes of Papez circuit with the exception of the mammillary bodies and hippocampal body and tail in the semantic variant of primary progressive aphasia. Despite the longer disease course in the semantic variant of primary progressive aphasia compared to behavioral variant frontotemporal dementia, we suggest here that the neural preservation of crucial memory relays (hippocampal_mammillary bodies and posterior cingulate_hippocampus) likely reflects the conservation of specific episodic memory components observed in most patients with semantic variant of primary progressive aphasia.
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Keyword:
Central Nervous System (FOR: 110903); Central Nervous System (RFCD: 320702); frontotemporal dementia; papez circuit; primary progressive aphasia; semantic dementia
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URL: http://handle.unsw.edu.au/1959.4/54030
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Longitudinal white matter changes in frontotemporal dementia subtypes
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Lam, Bonnie YK, Neuroscience Research Australia, Faculty of Medicine, UNSW; Halliday, Glenda, Neuroscience Research Australia, Faculty of Medicine, UNSW; Irish, Muireann, Neuroscience Research Australia, Faculty of Medicine, UNSW. - 2014
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New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications
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Chare, Leone, Neuroscience Research Australia, Faculty of Medicine, UNSW; Hodges, John R, Neuroscience Research Australia, Faculty of Medicine, UNSW; Leyton, Cristian E, Neuroscience Research Australia, Faculty of Medicine, UNSW. - 2014
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Development of figurative language skills following central nervous system-directed chemotherapy delivered in early childhood
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Investigating the role of glycosaminoglycans in the development and production of birdsong ; Doctor of Philosophy
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In: Original in Marriott Library Special Collections (2014)
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Laughter and MIRTH (Methodical Investigation of Risibility, Therapeutic and Harmful): narrative synthesis.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; CrossRef (2013)
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Dissociable Influences of Auditory Object vs. Spatial Attention on Visual System Oscillatory Activity
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Cognitive and subjective effects of mephedrone and factors influencing use of a 'new legal high'.
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In: Addiction , 107 (4) pp. 792-800. (2012) (2012)
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Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects
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Halliday, Glenda, Neuroscience Research Australia, Faculty of Medicine, UNSW; Bigio, Eileen H, 2Department of Pathology and Alzheimer Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Cairns, Nigel J, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA. - 2012
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COMMENTARY Challenges in diagnosis of isolated central nervous system vasculitis
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In: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/34/ff/Brain_Behav_2011_Sep_1(1)_57-61.tar.gz (2011)
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Auditory cortical N100 in pre- and post-synaptic auditory neuropathy to frequency or intensity changes of continuous tones.
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In: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, vol 122, iss 3 (2011)
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Redox Abnormalities as a Vulnerability Phenotype for Autism and Related Alterations in CNS Development
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In: DTIC (2011)
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Cranial pachymeningitis: a rare neurological syndrome with heterogeneous etiology
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: BMJ Publishing Group Ltd., 2011. : BMJ Journals, BMA House, London UK, 2011
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