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Rapport et Bilan Scientifique - 2e Symposium sur la Politique Linguistique Familiale 2021
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In: https://hal-inalco.archives-ouvertes.fr/hal-03525635 ; [Rapport de recherche] INALCO, Sorbonne Paris-Cité (SPC). 2022 (2022)
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WS16: Italian heritage: Using corpus data to map phonological patterns in Brazilian Veneto ...
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Analysis of Faecal Microbiota and Small ncRNAs in Autism: Detection of miRNAs and piRNAs with Possible Implications in Host–Gut Microbiota Cross-Talk
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In: Nutrients; Volume 14; Issue 7; Pages: 1340 (2022)
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Abstract:
Intestinal microorganisms impact health by maintaining gut homeostasis and shaping the host immunity, while gut dysbiosis associates with many conditions, including autism, a complex neurodevelopmental disorder with multifactorial aetiology. In autism, gut dysbiosis correlates with symptom severity and is characterised by a reduced bacterial variability and a diminished beneficial commensal relationship. Microbiota can influence the expression of host microRNAs that, in turn, regulate the growth of intestinal bacteria by means of bidirectional host-gut microbiota cross-talk. We investigated possible interactions among intestinal microbes and between them and host transcriptional modulators in autism. To this purpose, we analysed, by “omics” technologies, faecal microbiome, mycobiome, and small non-coding-RNAs (particularly miRNAs and piRNAs) of children with autism and neurotypical development. Patients displayed gut dysbiosis related to a reduction of healthy gut micro- and mycobiota as well as up-regulated transcriptional modulators. The targets of dysregulated non-coding-RNAs are involved in intestinal permeability, inflammation, and autism. Furthermore, microbial families, underrepresented in patients, participate in the production of human essential metabolites negatively influencing the health condition. Here, we propose a novel approach to analyse faeces as a whole, and for the first time, we detected miRNAs and piRNAs in faecal samples of patients with autism.
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Keyword:
autism spectrum disorders; gene-environment interaction; host–gut microbiota cross-talk; microbiome; microRNAs; multi-omics; mycobiome; piRNAs
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URL: https://doi.org/10.3390/nu14071340
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Writing and Linguistics News
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In: Writing & Linguistics News (2022)
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Rapport et Bilan Scientifique - 2e Symposium sur la Politique Linguistique Familiale 2021
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In: https://hal-inalco.archives-ouvertes.fr/hal-03525635 ; [Rapport de recherche] INALCO, Sorbonne Paris-Cité (SPC). 2022 (2022)
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Transit Zones, Locales, and Locations: How Digital Annotations Affect Communication in Public Places
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In: Media and Communication ; 9 ; 3 ; 39-49 ; Spaces, Places, and Geographies of Public Spheres (2022)
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Small Talk: A Big Challenge for Chinese Graduate Students in Canada
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Linguistique Interactionnelle: du Corpus à l'Expérimentation
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In: https://hal.archives-ouvertes.fr/tel-03500277 ; Linguistique. Aix Marseille Université, 2021 (2021)
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Equatorial Guinea Seeks Sustainable Language Use Through Community-based Language Development ...
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Mechanisms of Behavioral Change in a Culturally-Adapted MI with Latino Heavy Drinkers AIM ONE, R01, AA025485, NIAAA ...
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WS5: Cognitive mechanisms: Loan word accommodation biases in Dutch and Middle English: a question of processing cost? ...
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A brief sketch of the clause structure of Burkina Faso Sign Language (BFSL) ...
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“Have you ever seen a snake?": Personal experience narratives in village sign languages ...
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The incorporation of emblematic gestures in the emerging sign language of Guinea-Bissau ...
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