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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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German Language Adaptation of the NAVS (NAVS-G) and of the NAT (NAT-G): Testing Grammar in Aphasia
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In: Brain Sci (2021)
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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring
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In: Alzheimers Dement (Amst) (2021)
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German language adaptation of the NAVS (NAVS-G) and of the NAT (NAT-G): testing grammar in aphasia
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In: Brain sciences. - 11, 4 (2021) , 474, ISSN: 2076-3425 (2021)
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Data from: ApoE is a correlate of phenotypic heterogeneity in Alzheimer’s disease in a national cohort ...
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium
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In: Alzheimers Dement (2020)
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APOE is a correlate of phenotypic heterogeneity in Alzheimer disease in a national cohort
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In: Neurology (2020)
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Measurement and characterization of distinctive clinical phenotypes using the Frontotemporal Lobar Degeneration Module (FTLD-MOD)
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In: Alzheimers Dement (2020)
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Familial language network vulnerability in primary progressive aphasia
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Weintraub, Sandra; Rader, Benjamin; Coventry, Christina; Sridhar, Jaiashre; Wood, Jessica; Guillaume, Kyla A.; Coppola, Giovanni; Ramos, Eliana Marisa; Bonakdarpour, Borna; Rogalski, Emily J.; Mesulam, M. Marsel
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In: Neurology (2020)
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Abstract:
OBJECTIVE: To investigate evidence of the potential role of early cortical vulnerability in the development of primary progressive aphasia (PPA). METHOD: A woman with a diagnosis of PPA and her 9 adult siblings, 7 with developmental language disabilities, underwent neuropsychological testing, structural MRI, and resting-state fMRI. Whole-exome sequencing was conducted for genes associated with dyslexia or with neurodegenerative dementia. RESULTS: The siblings demonstrated lower verbal than nonverbal cognitive test scores in a developmental dyslexia pattern. On structural MRI, although the siblings did not differ from controls in total brain volume, the left hemisphere language area volume was significantly smaller than the right. Furthermore, cortical connectivity between the left superior temporal area, previously identified as the region of peak atrophy in the proband early in the course of illness, and adjacent language network components, including the planum temporale, was decreased in the siblings. No distinctive genetic signatures were identified. CONCLUSION: This report further supports the hypothesis that at least some cases of PPA may be based on a familial language network vulnerability that interferes with the acquisition of language in some members and that makes the language network a locus of least resistance to the effects of an independently late-arising neurodegenerative disease in others. This association offers a conceptual model to explain why identical neurodegenerative diseases may selectively target the language network in some individuals while targeting networks that regulate memory or behavior in others. The genetic basis for this vulnerability remains to be determined.
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605508/
http://www.ncbi.nlm.nih.gov/pubmed/32699140
https://doi.org/10.1212/WNL.0000000000009842
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Montreal Cognitive Assessment (MoCA) Performance and Domain-Specific Index Scores in Amnestic versus Aphasic Dementia
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In: J Int Neuropsychol Soc (2020)
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Genetic screen in a large series of patients with primary progressive aphasia
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PREFERENTIAL DISRUPTION OF AUDITORY WORD REPRESENTATIONS IN PRIMARY PROGRESSIVE APHASIA WITH THE NEUROPATHOLOGY OF FTLD-TDP TYPE A
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Northwestern Anagram Test-Italian (Nat-I) for primary progressive aphasia
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In: Cortex (2019)
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Clinical and cortical decline in the aphasic variant of Alzheimer’s disease
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Neuropathologic basis of in vivo cortical atrophy in the aphasic variant of Alzheimer’s disease
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In: Brain Pathol (2019)
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Word comprehension in temporal cortex and Wernicke area: A PPA perspective
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Morphology and Distribution of TDP-43 Pre-inclusions in Primary Progressive Aphasia
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