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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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German Language Adaptation of the NAVS (NAVS-G) and of the NAT (NAT-G): Testing Grammar in Aphasia
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In: Brain Sci (2021)
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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring
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In: Alzheimers Dement (Amst) (2021)
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German language adaptation of the NAVS (NAVS-G) and of the NAT (NAT-G): testing grammar in aphasia
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In: Brain sciences. - 11, 4 (2021) , 474, ISSN: 2076-3425 (2021)
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Data from: ApoE is a correlate of phenotypic heterogeneity in Alzheimer’s disease in a national cohort ...
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium
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In: Alzheimers Dement (2020)
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APOE is a correlate of phenotypic heterogeneity in Alzheimer disease in a national cohort
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In: Neurology (2020)
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Measurement and characterization of distinctive clinical phenotypes using the Frontotemporal Lobar Degeneration Module (FTLD-MOD)
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In: Alzheimers Dement (2020)
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Familial language network vulnerability in primary progressive aphasia
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In: Neurology (2020)
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Montreal Cognitive Assessment (MoCA) Performance and Domain-Specific Index Scores in Amnestic versus Aphasic Dementia
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In: J Int Neuropsychol Soc (2020)
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Genetic screen in a large series of patients with primary progressive aphasia
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PREFERENTIAL DISRUPTION OF AUDITORY WORD REPRESENTATIONS IN PRIMARY PROGRESSIVE APHASIA WITH THE NEUROPATHOLOGY OF FTLD-TDP TYPE A
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Northwestern Anagram Test-Italian (Nat-I) for primary progressive aphasia
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In: Cortex (2019)
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Clinical and cortical decline in the aphasic variant of Alzheimer’s disease
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Neuropathologic basis of in vivo cortical atrophy in the aphasic variant of Alzheimer’s disease
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In: Brain Pathol (2019)
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Word comprehension in temporal cortex and Wernicke area: A PPA perspective
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Morphology and Distribution of TDP-43 Pre-inclusions in Primary Progressive Aphasia
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Kim, Garam; Bolbolan, Kabriya; Shahidehpour, Ryan; Jamshidi, Pouya; Gefen, Tamar; Ayala, Ivan A; Weintraub, Sandra; Bigio, Eileen H; Mesulam, Marek-Marsel; Geula, Changiz. - : Oxford University Press, 2019
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Abstract:
Diffusely stained phosphorylated 43-kDa TAR DNA-binding protein (TDP-43)-positive “pre-inclusions” have been described. This experiment investigated morphological subtypes of pre-inclusions and their relationship with TDP-43 inclusions in primary progressive aphasia (PPA), a dementia characterized by gradual dissolution of language. Brain sections from 5 PPA participants with postmortem diagnoses of frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) were immunohistochemically stained using an antibody to phosphorylated TDP-43 and quantitatively examined for regional and hemispheric distribution using unbiased stereology. Cortical TDP-43 pre-inclusions included smooth, granular/dot-like, or fibrillar staining with localization to the nucleus, cytoplasm, or both. Mature and pre-inclusions were quantified in a region with high and a region with low mature inclusion density, and contralateral homologs. Regions with lower mature inclusions were characterized by higher densities of pre-inclusions, while increasing burden of inclusions corresponded to lower densities of pre-inclusions (p < 0.05). Mature inclusions showed significant asymmetry that favored the language-dominant hemisphere (p < 0.01), while pre-inclusions displayed the opposite pattern (p < 0.01). Granular-type pre-inclusions were more abundant (p < 0.05) and drove the hemispheric and regional differences (p < 0.02). These results suggest that pre-inclusions are present in greater abundance prior to the formation of mature TDP-43 inclusions, and appear to develop through progressive stages into mature intracytoplasmic, or intranuclear aggregates.
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Keyword:
Original Articles
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380320/ https://doi.org/10.1093/jnen/nlz005 http://www.ncbi.nlm.nih.gov/pubmed/30753613
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