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Maritime English as a code-tailored ESP: Genre-based curriculum development as a way out
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In: Ibérica: Revista de la Asociación Europea de Lenguas para Fines Específicos ( AELFE ), ISSN 1139-7241, Nº. 35, 2018, pags. 145-170 (2018)
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Operon mRNAs are organized into ORF-centric structures that predict translation efficiency
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Abstract:
Bacterial mRNAs are organized into operons consisting of discrete open reading frames (ORFs) in a single polycistronic mRNA. Individual ORFs on the mRNA are differentially translated, with rates varying as much as 100-fold. The signals controlling differential translation are poorly understood. Our genome-wide mRNA secondary structure analysis indicated that operonic mRNAs are comprised of ORF-wide units of secondary structure that vary across ORF boundaries such that adjacent ORFs on the same mRNA molecule are structurally distinct. ORF translation rate is strongly correlated with its mRNA structure in vivo, and correlation persists, albeit in a reduced form, with its structure when translation is inhibited and with that of in vitro refolded mRNA. These data suggest that intrinsic ORF mRNA structure encodes a rough blueprint for translation efficiency. This structure is then amplified by translation, in a self-reinforcing loop, to provide the structure that ultimately specifies the translation of each ORF.
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Keyword:
Computational and Systems Biology
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URL: https://doi.org/10.7554/eLife.22037 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318159/ http://www.ncbi.nlm.nih.gov/pubmed/28139975
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Query answering with inconsistent existential rules under stable model semantics
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Additional file 1: of A preliminary validation of the Brief COPE instrument for assessing coping strategies among people living with HIV in China ...
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Additional file 1: of A preliminary validation of the Brief COPE instrument for assessing coping strategies among people living with HIV in China ...
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Recruiting, training and retaining competent overseas English language teachers for private language teaching organisations in China.
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Intergroup Anxiety and Willingness to Communicate: Exploring the Effects of Stereotype Threat and Social Attraction
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Communicating with Americans: Chinese International Students' Experiences and Perceptions
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Exploring Multiple Literacies and Identities of Children in a Mandarin-English Bilingual Program ...
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Risk Assessment of Groundwater Contamination: A Multilevel Fuzzy Comprehensive Evaluation Approach Based on DRASTIC Model
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A Critical Review of Immigrant Children’s Literacies and Identities from a Deleuzian Perspective
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In: Journal of Contemporary Issues in Education; Vol 7, No 1 (2012) ; 1718-4770 (2012)
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Functions of the Common Ingroup Identity Model and Acculturation Strategies in Intercultural Communication: American Host Nationals' Communication with Chinese International Students
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Making Ourselves Understood: The Role of Previous Experience, Stereotypes, Communication Accommodation, and Anxiety in Americans' Perceptions of Communication with Chinese Students
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Constructing the Self through the Other: How beliefs about the Other inform international NGO approaches to development
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