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Constrained Density Matching and Modeling for Cross-lingual Alignment of Contextualized Representations ...
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Towards Explainable Evaluation Metrics for Natural Language Generation ...
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Global Explainability of BERT-Based Evaluation Metrics by Disentangling along Linguistic Factors ...
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Global Explainability of BERT-Based Evaluation Metrics by Disentangling along Linguistic Factors ...
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The Trans-Ancestral Genomic Architecture of Glycemic Traits
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In: Nat Genet (2021)
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On the Limitations of Cross-lingual Encoders as Exposed by Reference-Free Machine Translation Evaluation ...
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Regularized Attentive Capsule Network for Overlapped Relation Extraction ...
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On the limitations of cross-lingual encoders as exposed by reference-free machine translation evaluation
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On aligning OpenIE extractions with Knowledge Bases: A case study
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tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence
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Chionh, Yok Hian; McBee, Megan; Babu, I. Ramesh; Hia, Fabian; Lin, Wenwei; Zhao, Wei; Cao, Jianshu; Dziergowska, Agnieszka; Malkiewicz, Andrzej; Begley, Thomas J.; Alonso, Sylvie; Dedon, Peter C.
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In: Nature (2016)
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Abstract:
Microbial pathogens adapt to the stress of infection by regulating transcription, translation and protein modification. We report that changes in gene expression in hypoxia-induced non-replicating persistence in mycobacteria—which models tuberculous granulomas—are partly determined by a mechanism of tRNA reprogramming and codon-biased translation. Mycobacterium bovis BCG responded to each stage of hypoxia and aerobic resuscitation by uniquely reprogramming 40 modified ribonucleosides in tRNA, which correlate with selective translation of mRNAs from families of codon-biased persistence genes. For example, early hypoxia increases wobble cmo[superscript 5]U in tRNA[superscript Thr(UGU)], which parallels translation of transcripts enriched in its cognate codon, ACG, including the DosR master regulator of hypoxic bacteriostasis. Codon re-engineering of dosR exaggerates hypoxia-induced changes in codon-biased DosR translation, with altered dosR expression revealing unanticipated effects on bacterial survival during hypoxia. These results reveal a coordinated system of tRNA modifications and translation of codon-biased transcripts that enhance expression of stress response proteins in mycobacteria. ; Singapore-MIT Alliance for Research and Technology (SMART) ; National Institute of Environmental Health Sciences (grants ES017010 and ES002109) ; National Science Foundation (U.S.) (grant CHE-1308839) ; Singapore-MIT Alliance for Research and Technology (SMART) (SMA3 Graduate Fellowship)
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URL: http://hdl.handle.net/1721.1/105329
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The Violation of the Cooperative Principles in Conan
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In: Studies in Literature and Language; Vol 11, No 3 (2015): Studies in Literature and Language; 22-25 ; 1923-1563 ; 1923-1555 (2015)
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Byronic Hero and the Comparison With Other Heroes
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In: Studies in Literature and Language; Vol 10, No 6 (2015): Studies in Literature and Language; 29-32 ; 1923-1563 ; 1923-1555 (2015)
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An Analysis on how to Overcome the Cultural Barriers in Humor Translation - Application of the Dynamic Equivalence Principle to the Translation of Huang Xi's Jokes
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Zhao, Wei. - : The University of Queensland, School of Languages and Cultures, 2013
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