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Cortical microstructure in primary progressive aphasia: a multicenter study.
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Illán-Gala, Ignacio; Montal, Victor; Borrego-Écija, Sergi; Mandelli, Maria Luisa; Falgàs, Neus; Welch, Ariane E; Pegueroles, Jordi; Santos-Santos, Miguel; Bejanin, Alexandre; Alcolea, Daniel; Dols-Icardo, Oriol; Belbin, Olivia; Sánchez-Saudinós, Mª Belén; Bargalló, Nuria; González-Ortiz, Sofía; Lladó, Albert; Blesa, Rafael; Dickerson, Bradford C; Rosen, Howard J; Miller, Bruce L; Lleó, Alberto; Gorno-Tempini, Maria Luisa; Sánchez-Valle, Raquel; Fortea, Juan
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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Abstract:
BackgroundCortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes. We aimed to test the hypothesis that cortical mean diffusivity is more sensitive than cortical thickness to detect cortical changes in primary progressive aphasia (PPA).MethodsIn this multicenter, case-control study, we recruited 120 patients with PPA (52 non-fluent, 31 semantic, and 32 logopenic variants; and 5 GRN-related PPA) as well as 89 controls from three centers. The 3-Tesla MRI protocol included structural and diffusion-weighted sequences. Disease severity was assessed with the Clinical Dementia Rating scale. Cortical thickness and cortical mean diffusivity were computed using a surface-based approach.ResultsThe comparison between each PPA variant and controls revealed cortical mean diffusivity increases and cortical thinning in overlapping regions, reflecting the canonical loci of neurodegeneration of each variant. Importantly, cortical mean diffusivity increases also expanded to other PPA-related areas and correlated with disease severity in all PPA groups. Cortical mean diffusivity was also increased in patients with very mild PPA when only minimal cortical thinning was observed and showed a good correlation with measures of disease severity.ConclusionsCortical mean diffusivity shows promise as a sensitive biomarker for the study of the neurodegeneration-related microstructural changes in PPA.
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Keyword:
2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aging; Alzheimer's disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer’s disease; Aphasia; Biomedical Imaging; Brain Disorders; Case-Control Studies; Clinical Research; Dementia; Diffusion; Diffusion Magnetic Resonance Imaging; Frontotemporal Dementia (FTD); Frontotemporal lobar degeneration; Humans; Magnetic resonance; Magnetic Resonance Imaging; Medical and Health Sciences; Neurodegenerative; Neurological; Neurosciences; Primary Progressive; Primary progressive aphasia; Rare Diseases
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URL: https://escholarship.org/uc/item/4td346vg
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| 2 |
Protocol for the development of the international population registry for aphasia after stroke (I-PRAISE)
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In: Research outputs 2014 to 2021 (2022)
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| 3 |
An umbrella review of aphasia intervention description in research: The AsPIRE project
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In: Research outputs 2014 to 2021 (2022)
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| 4 |
Development and diagnostic validation of the Brisbane Evidence-Based Language Test
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In: Research outputs 2014 to 2021 (2022)
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Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: The RELEASE database of aphasia after stroke
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In: Research outputs 2014 to 2021 (2022)
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| 6 |
Inter-rater reliability, intra-rater reliability and internal consistency of the Brisbane Evidence-Based Language Test
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In: Research outputs 2014 to 2021 (2022)
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| 7 |
Developing, monitoring, and reporting of fidelity in aphasia trials: Core recommendations from the collaboration of aphasia trialists (CATs) trials for aphasia panel
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In: Research outputs 2022 to 2026 (2022)
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| 8 |
An aphasia research agenda – a consensus statement from the collaboration of aphasia trialists
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In: Research outputs 2014 to 2021 (2022)
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| 9 |
Investigation of the implementation of a communication enhanced environment model on an acute/slow stream rehabilitation and a rehabilitation ward: A before-and-after pilot study
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In: Research outputs 2014 to 2021 (2022)
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| 10 |
Neuro-Oncology Patients as Human Research Subjects: Ethical Considerations for Cognitive and Behavioral Testing for Research Purposes
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In: Cancers; Volume 14; Issue 3; Pages: 692 (2022)
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| 11 |
A Preliminary Report of Network Electroencephalographic Measures in Primary Progressive Apraxia of Speech and Aphasia
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In: Brain Sciences; Volume 12; Issue 3; Pages: 378 (2022)
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| 12 |
Effect of Lexical-Semantic Cues during Real-Time Sentence Processing in Aphasia
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In: Brain Sciences; Volume 12; Issue 3; Pages: 312 (2022)
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| 13 |
Primary and Secondary Progressive Aphasia in Posterior Cortical Atrophy
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In: Life; Volume 12; Issue 5; Pages: 662 (2022)
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| 14 |
Imaging Clinical Subtypes and Associated Brain Networks in Alzheimer’s Disease
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In: Brain Sciences; Volume 12; Issue 2; Pages: 146 (2022)
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| 15 |
Benefits from Repetitive Transcranial Magnetic Stimulation in Post-Stroke Rehabilitation
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In: Journal of Clinical Medicine; Volume 11; Issue 8; Pages: 2149 (2022)
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Syntactic deficits in language comprehension in individuals with schizophrenia and Broca's aphasia ...
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| 17 |
Syntactic deficits in language comprehension in individuals with schizophrenia and Broca's aphasia ...
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| 18 |
The contribution of white matter pathology, hypoperfusion, lesion load, and stroke recurrence to language deficits following acute subcortical left hemisphere stroke ...
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| 19 |
A 'Mini Linguistic State Examination' to classify primary progressive aphasia. ...
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A 'Mini Linguistic State Examination' to classify primary progressive aphasia. ...
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