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Gene Expression Imputation Across Multiple Tissue Types Provides Insight Into the Genetic Architecture of Frontotemporal Dementia and Its Clinical Subtypes
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A Multi-modal Machine Learning Approach and Toolkit to Automate Recognition of Early Stages of Dementia among British Sign Language Users
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Frontotemporal Dementia: Overview and Neuro-ophthalmologic Features
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Pavan Vaswani, MD, PhD, Movement Disorders Fellow; Ali G. Hamedani, MD, MHS, Assistant Professor of Neurology; Penn Medicine; University of Pennsylvania, Philadelphia, PA. - : Spencer S. Eccles Health Sciences Library, University of Utah, 2021
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The White Matter Module-Hub Network of Semantics Revealed by Semantic Dementia
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In: ISSN: 0898-929X ; EISSN: 1530-8898 ; Journal of Cognitive Neuroscience ; https://hal.inria.fr/hal-02554966 ; Journal of Cognitive Neuroscience, Massachusetts Institute of Technology Press (MIT Press), 2020, pp.1-18. ⟨10.1162/jocn_a_01549⟩ (2020)
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Abstract:
International audience ; 2AbstractCognitive neuroscience exploring the architecture of semantics has shown that coherent supra-modal concepts are computed in the anterior temporal lobes (ATL) but it is unknown how/where modularinformation implemented by posterior cortices (word/object/face forms) is conveyed to the ATL hub. We investigated the semantic module-hub network in healthy adults (N = 19) and in semantic dementia patients (N = 28) by combining semantic assessments of verbal and non-verbal stimuli and MRI-based fiber tracking usingseeds in three module-related cortices implementing i) written word forms (‘Visual Word Form Area’), ii) abstract lexical representations (posterior-superior temporal cortices), and iii) face/object representations (‘Face Form Area’).Fiber tracking revealed three key tracts linking the ATL with the three module-related cortices. Correlation analyses between tract parameters and semantic scores indicated that the three tracts subserve semantics, transferring modular verbal or non-verbal object/face information to the left and right ATL, respectively. The module-hub tracts were functionally and micro-structurally damaged in semantic dementia whereas damage to non-module specific ATL tracts (inferior longitudinal fasciculus, uncinate fasciculus) had more limited impact on semantic failure. These findings identify major components of the white matter module-hub network of semantics and they corroborate/materialize claims of cognitive models positing direct links between modular and semantic representations. In combination with modular accounts of cognition, they also suggest that the currently prevailing ‘hub-and-spokes’ model of semantics could be extended by incorporating an intermediate module level containing invariant representations, in addition to ‘spokes’ which subserve the processing of a near-unlimited number of sensori-motor and speech-sound features.
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Keyword:
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging; Diffusion MRI; Semantic dementia; Semantics; Tractograghy
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URL: https://hal.inria.fr/hal-02554966/file/Sundqvist-SemNetwork_Preprint.pdf https://hal.inria.fr/hal-02554966/document https://doi.org/10.1162/jocn_a_01549 https://hal.inria.fr/hal-02554966
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When affect overlaps with concept: emotion recognition in semantic variant of primary progressive aphasia
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In: ISSN: 0006-8950 ; EISSN: 1460-2156 ; Brain - A Journal of Neurology ; https://www.hal.inserm.fr/inserm-02924278 ; Brain - A Journal of Neurology , Oxford University Press (OUP), In press, ⟨10.1093/brain/awaa313⟩ (2020)
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Automated profiling of spontaneous speech in primary progressive aphasia and behavioral-variant frontotemporal dementia: An approach based on usage-frequency
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In: ISSN: 0010-9452 ; Cortex ; https://hal.archives-ouvertes.fr/hal-02993000 ; Cortex, Elsevier, 2020, 133, pp.103-119. ⟨10.1016/j.cortex.2020.08.027⟩ (2020)
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New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Comparing two facets of emotion perception across multiple neurodegenerative diseases.
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In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020)
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Amount and delay insensitivity during intertemporal choice in three neurodegenerative diseases reflects dorsomedial prefrontal atrophy.
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Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
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New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
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Graded, multidimensional intra- and intergroup variations in primary progressive aphasia and post-stroke aphasia.
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In: Brain : a journal of neurology, vol 143, iss 10 (2020)
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Comparing two facets of emotion perception across multiple neurodegenerative diseases.
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In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020)
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