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Lived Experience of Dementia in the New Zealand Indian Community: A Qualitative Study With Family Care Givers and People Living With Dementia
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Family history of FXTAS is associated with age-related cognitive-linguistic decline among mothers with the FMR1 premutation.
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In: Journal of neurodevelopmental disorders, vol 14, iss 1 (2022)
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Cortical microstructure in primary progressive aphasia: a multicenter study.
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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Bilingualism, Dementia, and the Neurological Mechanisms in Between: The Need for a More Critical Look Into Dementia Subtypes ...
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Lee, Yan-Yi. - : Apollo - University of Cambridge Repository, 2022
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Anosognosia in Dementia: Evaluation of Perfusion Correlates Using 99mTc-HMPAO SPECT and Automated Brodmann Areas Analysis
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In: Diagnostics; Volume 12; Issue 5; Pages: 1136 (2022)
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| 6 |
Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism
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In: Journal of Clinical Medicine; Volume 11; Issue 8; Pages: 2260 (2022)
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| 7 |
Semantic Feature Extraction Using SBERT for Dementia Detection
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In: Brain Sciences; Volume 12; Issue 2; Pages: 270 (2022)
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| 8 |
Changes in Pronoun Use a Decade before Clinical Diagnosis of Alzheimer’s Dementia—Linguistic Contexts Suggest Problems in Perspective-Taking
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In: Brain Sciences; Volume 12; Issue 1; Pages: 121 (2022)
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| 9 |
Determinants of Adherence to a “GRADIOR” Computer-Based Cognitive Training Program in People with Mild Cognitive Impairment (MCI) and Mild Dementia
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In: Journal of Clinical Medicine; Volume 11; Issue 6; Pages: 1714 (2022)
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| 10 |
Validation of the Visual Cognitive Assessment Test (VCAT) for the Early Diagnosis of Cognitive Impairment in Multilingual Population in Malaysia
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In: Psych; Volume 4; Issue 1; Pages: 38-48 (2022)
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| 11 |
The Understanding and Experiences of Living with Dementia in Chinese New Zealanders
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In: International Journal of Environmental Research and Public Health; Volume 19; Issue 3; Pages: 1280 (2022)
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| 12 |
Lived Experience of Dementia in the New Zealand Indian Community: A Qualitative Study with Family Care Givers and People Living with Dementia
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In: International Journal of Environmental Research and Public Health; Volume 19; Issue 3; Pages: 1432 (2022)
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| 13 |
Pilotstudie zur parodontalen Gesundheit bei Patienten mit frontotemporaler Demenz ...
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A 'Mini Linguistic State Examination' to classify primary progressive aphasia. ...
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| 15 |
A 'Mini Linguistic State Examination' to classify primary progressive aphasia. ...
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| 16 |
Role of community health workers in addressing dementia: A global perspective
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| 17 |
Temporal cognition: subjective time and its connection with memory in frontotemporal dementia
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Liu, Lulu. - : The University of Sydney, 2022. : Faculty of Science, School of Psychology, 2022
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Improving the diagnostic accuracy of primary progressive aphasia using cognitive tests
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Foxe, David Gordon. - : The University of Sydney, 2022. : Faculty of Science, School of Psychology, 2022
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Abstract:
Primary progressive aphasias (PPA) are rare younger-onset dementias that primarily affect speech and language functions. Three subtypes of PPA have been identified and are classified based on the presence or absence of core language, imaging, and clinical findings: logopenic (lv-PPA), non-fluent (nfv-PPA) and semantic variant (sv-PPA). Differentiating these variants is important for treatment and planning; however, assessment of the nfv-PPA and lv-PPA variants’ speech and language is often difficult for clinicians with limited expertise. As such, simple language, cognitive, and behavioural tests are needed to aid diagnosis. This thesis comprises five studies that investigates this issue. Chapter 3 showed that, relative to the other PPA variants, lv-PPA is particularly impaired on a simple measure of visuospatial short-term memory, and that this impairment relates to the grey matter intensity decrease of the parietal lobe and surrounding regions. Chapter 4 expanded on these findings using a novel, computerised visuospatial working memory test. Using the cognitive subdomain scores of a cognitive screening tool (ACE-III), Chapter 5 found that the cognitive profiles of the PPA variants were distinct at baseline visit and over time. Crucially, cognitive decline in lv-PPA was more widespread and rapid than in nfv-PPA and sv-PPA. Chapter 6 demonstrated that PPA profiling is enhanced when evaluating the individual items of the ACE-III, and an interactive online ACE-III PPA diagnostic calculator was built for clinicians. Finally, Chapter 7 established that the mood, behaviour, and everyday skills profiles of the PPA variants are distinct at initial presentation and over the disease course. The work within this thesis demonstrates that the evolving cognitive and behavioural profiles of the PPA variants are distinct and extend beyond the primary disorder of language. Accordingly, assessing these skills in clinical practice can improve the diagnostic accuracy of the PPA variants.
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Keyword:
Alzheimer's disease; frontotemporal dementia; neuropsy; primary progressive aphasia
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URL: https://hdl.handle.net/2123/27582
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| 19 |
Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant
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In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021)
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Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
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